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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR432 IGR427 IGR429 IGR430 IGR428 IGR425 IGR434 IGR431 IGR426 IGR424 hopD,comC, - SMu0490 SMu0495 SMu0497 SMu0494 dpr, - SMu0491 trpA, - SMu0489 glk, - SMu0493 murG, - SMu0499 ftsQ,divIB, - SMu0500 murD, - SMu0498 typA,bipA, - SMu0496 hopD,comC, - SMu0490 SMu0495 SMu0497 SMu0494 dpr, - SMu0491 trpA, - SMu0489 glk, - SMu0493 murG, - SMu0499 ftsQ,divIB, - SMu0500 murD, - SMu0498 typA,bipA, - SMu0496 hopD,comC, - SMu0490 SMu0497 SMu0494 dpr, - SMu0491 trpA, - SMu0489 glk, - SMu0493 murG, - SMu0499 ftsQ,divIB, - SMu0500 murD, - SMu0498 typA,bipA, - SMu0496 SMu0492 SMu0492 SMu0495


LANL Gene ID: SMu0496

GenBank Locus Tag: SMU.546

DNA Molecule Name:
1  

GenBank ID:
24379027

Gene Name:
typA  bipA  

Definition:
GTP-binding protein (tyrosine phosphorylated protein A); possible elongation factor

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
508256

Gene Stop:
510100

Gene Length:
1845

Molecular Weight*:
68419

pI*:
4.80

Net Charge*:
-25.30

EC:
 

Functional Class:
Unassigned  

Gene Ontology:
Cellular component
  GO:0005622    intracellular

Molecular function
  GO:0003924    GTPase activity
  GO:0005525    GTP binding


Pathway: pathway table

Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gaped BLAST to GTP-binding proteins. Residues 1-598 are 90% similar to 15675426, a predicted TypA/BipA protein from S.pyogenes and are also 90% similar to 15900582, a predicted Tu family elongation factor protein from S.pneumoniae.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0473 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379027|ref|NP_720982.1|  putative GTP-binding protein [...  1149   0.0  
 gi|15675426|ref|NP_269600.1|  putative GTP-binding protein T...  1101   0.0  
 gi|19746476|ref|NP_607612.1|  putative GTP-binding protein [...  1100   0.0  
 gi|55820795|ref|YP_139237.1|  GTP-binding protein TypA/BipA ...  1092   0.0  
 gi|15900582|ref|NP_345186.1|  elongation factor Tu family pr...  1091   0.0  
 gi|116516567|ref|YP_816092.1|  elongation factor Tu family p...  1091   0.0  
 gi|148997237|ref|ZP_01824891.1|  elongation factor Tu family...  1091   0.0  
 gi|55822696|ref|YP_141137.1|  GTP-binding protein TypA/BipA ...  1090   0.0  
 gi|149010696|ref|ZP_01832067.1|  elongation factor Tu family...  1089   0.0  
 gi|15902642|ref|NP_358192.1|  GTP-binding protein TypA/BipA ...  1089   0.0


InterPro Summary:  InterProScan

InterPro
IPR000640
Domain
Translation elongation factor EFG/EF2, C-terminal
G3DSA:3.30.70.240 [403-492]T 1.2999992446818301E-21 G3DSA:3.30.70.240 Transl_elong_EFG/EF2_C Transl_elong_EFG/EF2_C
PF00679 [400-485]T 3.0999994589937596E-24 PF00679 EFG_C EFG_C
InterPro
IPR000795
Domain
Protein synthesis factor, GTP-binding
PR00315 [10-23]T 9.9E-16 PR00315 ELONGATNFCT[54-62]T 9.9E-16 PR00315 ELONGATNFCT[74-84]T 9.9E-16 PR00315 ELONGATNFCT[90-101]T 9.9E-16 PR00315 ELONGATNFCT[126-135]T 9.9E-16 PR00315 ELONGATNFCT ELONGATNFCT
PF00009 [6-203]T 1.3000049540732397E-63 PF00009 GTP_EFTU GTP_EFTU
PS00301 [47-62]T 8.0E-5 PS00301 EFACTOR_GTP EFACTOR_GTP
InterPro
IPR004161
Domain
Translation elongation factor EFTu/EF1A, domain 2
PF03144 [224-294]T 8.90000829418149E-14 PF03144 GTP_EFTU_D2 GTP_EFTU_D2
InterPro
IPR005225
Domain
Small GTP-binding protein domain
TIGR00231 [6-180]T 1.27509465860646E-18 TIGR00231 small_GTP small_GTP
InterPro
IPR006298
Family
GTP-binding protein TypA
TIGR01394 [8-604]T 0.0 TIGR01394 TypA_BipA TypA_BipA
InterPro
IPR009000
Domain
Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447 [154-305]T 1.9999999999999997E-31 SSF50447 Translat_factor Translat_factor
InterPro
IPR009022
Domain
Elongation factor G, III and V
SSF54980 [335-391]T 2.5E-8 SSF54980 EFG_III_V[403-528]T 5.7E-31 SSF54980 EFG_III_V EFG_III_V
noIPR
unintegrated
unintegrated
G3DSA:2.40.30.10 [205-306]T 6.09999977126217E-7 G3DSA:2.40.30.10 G3DSA:2.40.30.10 G3DSA:2.40.30.10
G3DSA:3.40.50.300 [5-205]T 4.60000044330908E-57 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR23115 [5-326]T 0.0 PTHR23115 PTHR23115 PTHR23115
PTHR23115:SF14 [5-326]T 0.0 PTHR23115:SF14 PTHR23115:SF14 PTHR23115:SF14
SSF52540 [1-213]T 9.999999999999999E-57 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 6 clades of COG1217
COG name: Membrane GTPase
Functional Class: N
The phylogenetic pattern of COG1217 is -------cebrhuj------x
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB000640 (Elongation factor G, C-terminus) with a combined E-value of 1.5e-53.
    IPB000640A    8-33
    IPB000640B    46-68
    IPB000640C    73-100
    IPB000640D    107-135
    IPB000640E    191-202
    IPB000640F    397-431
***** IPB000795 (GTP-binding elongation factor) with a combined E-value of 3.7e-30.
    IPB000795A    10-25
    IPB000795B    76-107
    IPB000795C    111-135
***** IPB000178 (Initiation factor 2) with a combined E-value of 8.8e-19.
    IPB000178A    7-45
    IPB000178B    73-105
    IPB000178C    106-145


 ProDom Summary:  Protein Domain Search
Residues 93-173 are 96% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055 which is seen in Q9CE33_LACLA.

Residues 304-416 are 92% similar to a (GTP-BINDING PROTEOME COMPLETE TYPA/BIPA) protein domain (PD011418 which is seen in Q9CE33_LACLA.

Residues 420-479 are 81% similar to a (GTP-BINDING ELONGATION FACTOR BIOSYNTHESIS PROTEOME) protein domain (PD011419 which is seen in Q9CE33_LACLA.

Residues 199-303 are 62% similar to a (GTP-BINDING PROTEOME COMPLETE FACTOR) protein domain (PD004660 which is seen in TYPA_BACSU.

Residues 484-594 are 70% similar to a (GTP-BINDING PROTEOME COMPLETE TYPA/BIPA) protein domain (PD407411 which is seen in Q9K9L3_BACHD.

Residues 51-84 are 73% similar to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS 1-ALPHA) protein domain (PD350470 which is seen in TYPA_HELPY.

Residues 87-151 are 55% similar to a (FACTOR ELONGATION GTP-BINDING) protein domain (PD404337 which is seen in O82278_ARATH.

Residues 20-149 are 36% similar to a (GTP-BINDING ADP-RIBOSYLATION MULTIGENE FAMILY ALPHA) protein domain (PD076602 which is seen in IF2_THEMA.

Residues 65-155 are 30% similar to a (FACTOR ELONGATION GTP-BINDING LIKE) protein domain (PD302693 which is seen in EFGL_MYCTU.

Residues 254-303 are 86% similar to a (GTP-BINDING TYPA/BIPA HOMOLOG PROTEOME) protein domain (PD348560 which is seen in Q9CE33_LACLA.

Residues 52-84 are 87% similar to a (FACTOR GTP-BINDING BIOSYNTHESIS INITIATION ELONGATION) protein domain (PD336744 which is seen in Q9RV32_DEIRA.

Residues 253-303 are 47% similar to a (PROTEOME GTP-BINDING COMPLETE FACTOR) protein domain (PD399323 which is seen in Q9HU67_PSEAE.

Residues 198-252 are 63% similar to a (GTP-BINDING PROTEOME COMPLETE TYPA/BIPA) protein domain (PD383618 which is seen in Q9CE33_LACLA.

Residues 13-135 are 34% similar to a (C215.12 GTP-BINDING CHROMOSOME II) protein domain (PD196535 which is seen in O94316_SCHPO.

Residues 87-135 are 51% similar to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS RESISTANCE) protein domain (PD368385 which is seen in EF2_METBU.

Residues 6-49 are 86% similar to a (GTP-BINDING FACTOR ELONGATION BIOSYNTHESIS RESISTANCE) protein domain (PD000122 which is seen in Q9CE33_LACLA.


Paralogs:  Local Blast Search
SMu0496 is paralogously related (blast p-value < 1e-3) to SMu1271, SMu0324, SMu0651, SMu0554, SMu0382, and SMu1744, GTP-binding proteins.


Pfam Summary:  Pfam Search
Residues 6 to 203 (E-value = 2e-66) place SMu0496 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)
Residues 224 to 294 (E-value = 1.1e-16) place SMu0496 in the GTP_EFTU_D2 family which is described as Elongation factor Tu domain 2 (PF03144)
Residues 400 to 488 (E-value = 3e-35) place SMu0496 in the EFG_C family which is described as Elongation factor G C-terminus (PF00679)

 Top PDB Hits:
pdb|1FNM|A Chain A, Structure Of Thermus Thermophilus Ef-G H573a 111 2e-025
pdb|1ELO| Elongation Factor G Without Nucleotide >gi|1633250|... 111 2e-025
pdb|2EFG|A Chain A, Translational Elongation Factor G Complexed... 109 7e-025

Gene Protein Sequence:
MTNFREDIRNVAIIAHVDHGKTTLVDELLKQSHTLDEHKKLEERAMDSND
LEKERGITILAKNTAVAYNGVRINIMDTPGHADFGGEVERIMKMVDGVVL
VVDAYEGTMPQTRFVLKKALEQNLVPIVVVNKIDKPSARPAEVVDEVLEL
FIELGADDDQLEFPVVYASAINGTSSLSDEPADQEHTMAPVFDTIIEHIP
APIDNSDQPLQFQVSLLDYNDFVGRIGIGRVFRGSVKVGDQVTLSKLDGT
TKNFRVTKLFGFFGLERREIKEAKAGDLIAVSGMEDIFVGETITPTDAVE
PLPILHIDEPTLQMTFLANNSPFAGREGKFVTSRKVEERLLAELQTDVSL
RVEATDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIIKEIDGI
KCEPFERVQIDTPEEYQGAVIQSLSERKGEMLDMQATGNGQTRLIFLAPA
RGLIGYPTEFLSMTRGYGIMNHTFDKYMPVINAEIGGRHRGALVSIDTGK
ATTYSIMSIEERGTIFVNPGTEVYEGMIIGENARENDLTVNITKAKQMTN
VRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILDKN
ARAKAAKKKKSAED

Gene Nucleotide Sequence:  Sequence Viewer
ATGACAAATTTTAGAGAAGATATTAGAAATGTTGCTATCATTGCCCACGT
TGACCATGGGAAAACAACCCTTGTTGATGAGCTCTTAAAACAATCGCATA
CACTTGATGAGCATAAAAAATTAGAAGAACGTGCGATGGACTCTAATGAT
CTTGAAAAAGAGCGTGGGATTACTATTCTTGCAAAAAATACTGCTGTTGC
CTACAATGGTGTACGTATTAACATTATGGACACACCAGGACATGCGGATT
TTGGTGGAGAAGTAGAGCGTATCATGAAAATGGTTGATGGGGTTGTTCTT
GTTGTTGATGCTTATGAAGGTACCATGCCGCAAACACGTTTTGTTTTGAA
AAAAGCTTTGGAACAAAACCTGGTTCCAATCGTGGTGGTGAATAAGATTG
ACAAGCCATCAGCTCGTCCGGCAGAAGTTGTTGATGAAGTTCTTGAACTT
TTCATTGAACTTGGAGCAGATGATGACCAGTTAGAGTTTCCAGTCGTTTA
CGCTTCGGCGATTAATGGAACTTCTTCATTATCAGATGAACCAGCGGATC
AAGAACATACAATGGCACCCGTTTTTGATACTATTATTGAGCATATTCCA
GCACCGATCGATAATTCAGATCAGCCACTTCAATTTCAAGTGTCTCTCCT
TGATTATAACGACTTTGTTGGACGTATCGGTATTGGGCGAGTCTTCCGTG
GTTCTGTTAAAGTCGGGGATCAAGTGACACTTTCTAAACTTGATGGTACA
ACAAAGAATTTTCGTGTTACAAAACTTTTCGGTTTCTTCGGTTTGGAACG
TCGTGAGATTAAGGAAGCTAAGGCTGGCGATTTGATTGCTGTTTCAGGTA
TGGAAGATATCTTTGTTGGTGAAACGATTACACCAACTGATGCTGTAGAA
CCACTTCCTATTCTTCACATTGATGAGCCAACTCTGCAAATGACCTTTTT
AGCTAACAATTCCCCTTTTGCAGGCCGTGAAGGTAAATTTGTAACCTCGC
GTAAGGTAGAAGAGCGTTTGTTGGCAGAATTGCAAACAGATGTTTCCCTT
CGTGTAGAAGCCACTGACTCACCAGATAAATGGACGGTTTCAGGTCGTGG
GGAGTTACATCTGTCAATCCTTATTGAAACCATGCGCCGTGAAGGATATG
AGCTGCAAGTATCGCGTCCAGAAGTTATTATCAAAGAAATTGATGGCATC
AAATGTGAGCCATTTGAACGCGTGCAAATTGACACACCGGAAGAATACCA
AGGTGCTGTTATCCAGTCCCTTTCAGAACGTAAAGGTGAAATGCTTGATA
TGCAAGCAACTGGTAATGGTCAAACGCGCCTTATATTTTTAGCACCAGCT
CGAGGACTTATCGGCTACCCAACAGAATTCTTATCCATGACACGAGGTTA
TGGTATCATGAACCACACTTTTGACAAATATATGCCAGTTATCAATGCTG
AAATCGGTGGTCGTCATCGTGGTGCCCTCGTTTCAATTGATACAGGTAAG
GCAACGACTTATTCTATTATGTCTATTGAAGAACGTGGAACAATCTTCGT
TAACCCAGGTACAGAAGTGTATGAAGGAATGATTATTGGAGAAAATGCAC
GCGAGAATGATTTGACAGTCAACATTACAAAGGCTAAGCAGATGACTAAT
GTGCGCTCTGCAACCAAGGATCAGACAGCAGTTATTAAGACGCCGCGTAT
TTTAACACTTGAAGAATCACTTGAGTTTCTGAATGATGATGAATACATGG
AAGTAACACCTGAGTCCATTCGTTTACGTAAACAAATTCTTGATAAGAAT
GCGCGTGCTAAAGCGGCTAAGAAGAAAAAATCAGCTGAAGATTGA

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