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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1446 IGR1448 IGR1450 IGR1449 IGR1451 IGR1447 IGR1445 nusB, - SMu1680 comEB, - SMu1684 elp,efp, - SMu1682 scrA, - SMu1677 uvrA, - SMu1686 SMu1683 scrR, - SMu1679 scrB, - SMu1678 nusB, - SMu1680 comEB, - SMu1684 elp,efp, - SMu1682 scrA, - SMu1677 uvrA, - SMu1686 SMu1683 scrR, - SMu1679 scrB, - SMu1678 Type: tandem, Name: SMu-TR-31 - 31 Type: tandem, Name: SMu-TR-31 - 31 nusB, - SMu1680 comEB, - SMu1684 elp,efp, - SMu1682 scrA, - SMu1677 uvrA, - SMu1686 SMu1681 pepP, - SMu1685 pepP, - SMu1685 SMu1681 SMu1683 scrR, - SMu1679 scrB, - SMu1678


LANL Gene ID: SMu1680

GenBank Locus Tag: SMU.1845c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
nusB  

Definition:
transcription antitermination factor

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1744424

Gene Stop:
1743996

Gene Length:
429

Molecular Weight*:
16504

pI*:
6.60

Net Charge*:
-0.56

EC:
 

Functional Class:
Transcription; Transcription factors  

Gene Ontology:
Biological process
  GO:0006353    transcription termination
  GO:0006355    regulation of transcription, DNA-dependent

Molecular function
  GO:0003715    transcription termination factor activity
  GO:0003723    RNA binding


Pathway: pathway table

Secondary Evidence:
Carlomagno MS, Nappo A.
The antiterminator NusB enhances termination at a sub-optimal Rho site.
J Mol Biol. 2001 May 25;309(1):19-28.
PMID: 11491288

Comment:
For other 'nus'genes see SMu1769 (nusG) and SMu1680 (nusB).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to nusB proteins. Residues 1-138 are 58% similar to gi15675648 from S.pyogenes. Residues 1-142 are 51% similar to gi15902434 from S.pneumoniae.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1693 (1e-45).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380206|ref|NP_722161.1|  transcription antitermination ...   261   9e-69
 gi|22537833|ref|NP_688684.1|  transcription antitermination ...   184   2e-45
 gi|94995000|ref|YP_603098.1|  N utilization substance protei...   179   4e-44
 gi|71904194|ref|YP_280997.1|  transcription antitermination ...   179   5e-44
 gi|94991121|ref|YP_599221.1|  N utilization substance protei...   179   6e-44
 gi|71911358|ref|YP_282908.1|  transcription antitermination ...   179   7e-44
 gi|119390836|sp|Q1J532|NUSB_STRPF  N utilization substance p...   178   8e-44
 gi|19746754|ref|NP_607890.1|  transcription antitermination ...   178   9e-44
 gi|50914880|ref|YP_060852.1|  transcription antitermination ...   178   9e-44
 gi|119390835|sp|Q1JF82|NUSB_STRPD  N utilization substance p...   177   1e-43


InterPro Summary:  InterProScan

InterPro
IPR006027
Domain
NusB/RsmB/TIM44
G3DSA:1.10.940.10 [6-138]T 9.30000048475962E-34 G3DSA:1.10.940.10 NusB_RsmB_TIM44 NusB_RsmB_TIM44
PF01029 [10-141]T 9.50001028167257E-26 PF01029 NusB NusB
InterPro
IPR011605
Family
NusB antitermination factor
TIGR01951 [9-139]T 3.9291890135156103E-51 TIGR01951 nusB nusB
noIPR
unintegrated
unintegrated
SSF48013 [8-138]T 4.0999999999999995E-36 SSF48013 SSF48013 SSF48013


COGS Summary:  COGS Search
BeTs to 11 clades of COG0781
COG name: Transcription termination factor NusB
Functional Class: K
The phylogenetic pattern of COG0781 is -----qvcebrhuj--olinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB000139 (Antitermination protein NusB) with a combined E-value of 4e-26.
    IPB000139A    9-20
    IPB000139B    87-99
    IPB000139C    105-137


 ProDom Summary:  Protein Domain Search
Residues 60-138 are 49% similar to a (COMPLETE PROTEOME TRANSCRIPTION) protein domain (PD005242 which is seen in Q9CHN4_LACLA.


Paralogs:  Local Blast Search
SMu1680 is paralogously related (blast p-value < 1e-3) to SMu0436, a predicted RNA-binding Sun protein; possible rRNA methylase.


Pfam Summary:  Pfam Search
Residues 10 to 141 (E-value = 8.5e-29) place SMu1680 in the NusB family which is described as NusB family (PF01029)

 Top PDB Hits:
pdb1EYVA Chain A, The Crystal Structure Of Nusb From Mycobact... 71 5e-014
pdb1EY1A Chain A, Solution Structure Of Escherichia Coli Nusb... 63 2e-011

Gene Protein Sequence:
MTNVFVDSRRDLRERAFQALFSLEFGGDNLTAARFAYTYDKNEEEEAELP
LFLLTLIQGVSDCRREIDKNISIHLKSGWTLSRLTLIDKSLLRLGLYEIK
YHKETPERVALNEIIEIAKKYSDEKSSKFINGVLSQFVLERK

Gene Nucleotide Sequence:  Sequence Viewer
ATGACTAATGTATTTGTGGACTCTAGGCGCGATCTTCGTGAACGTGCTTT
TCAAGCACTTTTTTCTTTGGAATTTGGTGGCGATAATTTAACAGCAGCAA
GATTTGCTTATACTTATGATAAAAATGAAGAGGAAGAGGCTGAACTTCCT
CTCTTCTTACTGACTTTAATACAAGGTGTATCTGATTGTAGAAGGGAAAT
AGATAAGAATATTTCTATTCATCTAAAATCTGGCTGGACGCTTTCTCGAT
TGACTTTGATTGATAAGAGCCTGTTGCGTTTAGGTTTATACGAAATTAAA
TATCATAAGGAAACACCAGAACGTGTTGCTCTTAATGAAATTATTGAAAT
TGCAAAAAAGTATTCAGATGAGAAATCCAGTAAGTTTATTAATGGCGTTT
TAAGTCAGTTTGTGCTTGAAAGAAAATAA

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