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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1312 IGR1306 IGR1315 IGR1307 IGR1308 IGR1313 IGR1314 IGR1309 IGR1305 SMu1522 SMu1512 SMu1523 kthY,tmk, - SMu1515 acuB,acoB, - SMu1516 livF, - SMu1517 livG, - SMu1518 SMu1511 livH, - SMu1520 holB, - SMu1514 livM, - SMu1519 livK, - SMu1521 SMu1522 SMu1512 SMu1523 kthY,tmk, - SMu1515 acuB,acoB, - SMu1516 livF, - SMu1517 livG, - SMu1518 SMu1511 livH, - SMu1520 holB, - SMu1514 livM, - SMu1519 livK, - SMu1521 SMu1523 kthY,tmk, - SMu1515 acuB,acoB, - SMu1516 livF, - SMu1517 livG, - SMu1518 SMu1511 livH, - SMu1520 holB, - SMu1514 livM, - SMu1519 livK, - SMu1521 yaaT,lspA, - SMu1513 yaaT,lspA, - SMu1513 SMu1522 SMu1512


LANL Gene ID: SMu1517

GenBank Locus Tag: SMU.1665c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
livF  

Definition:
branched chain amino acid ABC transporter, ATP-binding protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
1582473

Gene Stop:
1581763

Gene Length:
711

Molecular Weight*:
25577

pI*:
6.00

Net Charge*:
-1.51

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Secondary Evidence:
Qi,F., Chen,P. and Caufield,P.W.
Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in streptococcus mutans
Appl. Environ. Microbiol. 65 (2), 652-658 (1999)
PubMed: 9925596

Comment:
For other components see SMu1518 (NBD1); SMu1520 (MSD1); SMu1519 (MSD2) and SMu1521 (SBP1).

For other 'liv' genes see SMu1518 (livG); SMu1519 (livM); SMu1520 (livH); SMu1521 (livK) and SMu1316 (livG).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Significant hits in gapped BLAST to branched-chain ABC transporter ATP-binding proteins. Residues 1-236 are 81% similar to >15900648 in S. pneumoniae. Residues 2-235 are 56% similar to >7480525 in S.coelicolor.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1578 (2e-99).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380043|ref|NP_721998.1|  putative branched chain amino ...   430   e-119
 gi|125718524|ref|YP_001035657.1|  Branched-chain amino acid ...   389   e-107
 gi|157076473|gb|ABV11156.1|  branched-chain amino acid ABC t...   389   e-106
 gi|146319197|ref|YP_001198909.1|  ABC-type branched-chain am...   385   e-106
 gi|81177277|ref|ZP_00876125.1|  ABC transporter [Streptococc...   385   e-105
 gi|148985897|ref|ZP_01818991.1|  branched-chain amino acid A...   382   e-105
 gi|15900648|ref|NP_345252.1|  branched-chain amino acid ABC ...   382   e-104
 gi|149010621|ref|ZP_01831992.1|  branched-chain amino acid A...   380   e-104
 gi|15902707|ref|NP_358257.1|  ABC transporter ATP-binding pr...   379   e-104
 gi|149007632|ref|ZP_01831249.1|  branched-chain amino acid A...   379   e-104


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [136-169]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [29-212]T 8.000026593468089E-48 PF00005 ABC_tran ABC_tran
PS00211 [137-151]? 0.0 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [4-236]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [28-215]T 1.5000000000000002E-7 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [3-235]T 4.2000346049305606E-67 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [4-233]T 7.49999605851013E-122 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF13 [4-233]T 7.49999605851013E-122 PTHR19222:SF13 PTHR19222:SF13 PTHR19222:SF13
SSF52540 [3-235]T 4.4000000000000005E-63 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 4 clades of COG0410
COG name: High-affinity branched amino acid transport system ATPase
Functional Class: E
The phylogenetic pattern of COG0410 is Am----vCe------------
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.8e-23.
    IPB001140A    18-64
    IPB001140B    134-172
    IPB001140C    189-218


 ProDom Summary:  Protein Domain Search
Residues 186-235 are 64% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD051514 which is seen in Q9S2J1_STRCO.

Residues 74-132 are 47% similar to a (ATP-BINDING PROTEOME COMPLETE ACID) protein domain (PD236901 which is seen in Q9RVJ4_DEIRA.

Residues 9-219 are 24% similar to a (C24F3.5) protein domain (PD218211 which is seen in Q21213_CAEEL.

Residues 19-69 are 58% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9S2J1_STRCO.

Residues 136-169 are 94% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9S2J1_STRCO.


Paralogs:  Local Blast Search
SMu1517 is paralogously related (blast p-value < 1e-3) to branched chain amino acid ABC transporter, ATP-binding proteins: SMu1518, SMu0971, SMu0517, SMu0218, SMu1003, SMu1410, SMu1380, SMu0374, SMu0258, SMu0418, SMu1079, SMu1036, SMu1920, SMu0884, SMu0731, SMu1710, SMu1023, SMu0849, SMu1068, SMu0950, SMu0976, SMu1210, SMu1246, SMu1231, SMu0596, SMu0594, SMu0390, SMu0335, SMu1649, SMu0235, SMu1949, SMu0216, SMu1950, SMu1762, SMu1316, SMu0786, SMu0234, SMu0916, SMu0805, SMu1724, SMu0907, SMu1428, SMu0944, SMu0476, SMu0164, SMu1037, SMu0987, SMu1001, SMu0475, SMu1757, SMu1288, SMu1751, SMu0666, SMu1811, SMu0824, SMu0836, SMu0825, SMu1050, SMu0837, SMu1093, SMu0752, SMu1545, SMu1065, SMu0986, SMu1959, SMu0024, SMu1064, SMu0224, SMu0823, SMu1306, SMu0729, SMu1686, and SMu1202, all ATP-binding proteins.


Pfam Summary:  Pfam Search
Residues 29 to 212 (E-value = 2.5e-49) place SMu1517 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 94 1e-020
pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 89 7e-019

Gene Protein Sequence:
MAMLKVENLSVHYGVIQAVKDVSFDVNEGEVVSLIGANGAGKTSILRTIS
GLVRPSSGEINFLGNDIQKAATRKIVASGLSQVPEGRHVFPGLTVLENLE
MGAFLSNNREENLARLKRVFERFPRLEERKNQDAATLSGGEQQMLAMGRA
LMSQPKLLLLDEPSMGLAPIFIQEIFDIIQDIQKQGTTVLLIEQNAKKAL
SIADRGYVLETGKIVLSGTGKELLASDEVQKAYLGG

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCGATGTTAAAAGTTGAGAATTTATCTGTTCATTATGGTGTTATCCA
AGCAGTCAAAGATGTGTCTTTTGACGTCAATGAAGGGGAAGTCGTTTCTC
TTATTGGTGCCAATGGTGCTGGCAAGACCTCTATTTTACGAACTATTTCG
GGTTTGGTGCGTCCAAGTTCAGGGGAAATTAATTTTTTAGGAAATGATAT
TCAAAAAGCTGCAACTCGAAAAATTGTAGCTTCTGGTCTGTCTCAGGTTC
CAGAAGGGCGACATGTTTTTCCTGGTTTAACAGTTTTAGAAAACTTAGAA
ATGGGAGCTTTTTTGAGCAATAATCGTGAGGAAAATCTAGCACGCTTAAA
AAGAGTGTTTGAACGTTTCCCGCGCTTGGAAGAGCGTAAAAATCAAGATG
CAGCAACCCTTTCTGGCGGTGAGCAGCAAATGCTTGCCATGGGGCGTGCT
CTCATGAGTCAGCCTAAGCTGCTTTTGCTTGATGAGCCATCTATGGGATT
GGCACCAATTTTTATACAAGAAATTTTTGACATCATTCAAGATATTCAAA
AGCAGGGGACAACAGTGCTTTTGATTGAGCAAAATGCTAAGAAGGCCCTG
TCAATTGCAGATCGTGGCTATGTTTTGGAAACTGGAAAGATTGTTCTTTC
AGGTACAGGCAAAGAATTATTGGCTTCTGATGAAGTTCAAAAAGCTTATT
TAGGTGGATAA

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