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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR914 IGR916 IGR911 IGR912 IGR910 IGR915 IGR913 SMu1061 acrR, - SMu1066 psaA, - SMu1068 SMu1063 SMu1062 SMu1065 ylbB,psaB, - SMu1067 SMu1061 acrR, - SMu1066 psaA, - SMu1068 SMu1063 SMu1062 SMu1065 ylbB,psaB, - SMu1067 acrR, - SMu1066 psaA, - SMu1068 SMu1063 SMu1062 SMu1065 ylbB,psaB, - SMu1067 SMu1064 SMu1064 SMu1061


LANL Gene ID: SMu1065

GenBank Locus Tag: SMU.1164c

DNA Molecule Name:
1  

GenBank ID:
24379594

Gene Name:


Definition:
ABC transporter, ATPase component

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
1103859

Gene Stop:
1102087

Gene Length:
1773

Molecular Weight*:
65637

pI*:
5.50

Net Charge*:
-9.88

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: membrane spanning permease  

Gene Ontology:
Biological process
  GO:0006810    transport

Cellular component
  GO:0016021    integral to membrane

Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity
  GO:0042626    ATPase activity, coupled to transmembrane movement of substances


Pathway: pathway table

Primary Evidence:
Qi,F., Chen,P. and Caufield,P.W.
Purification of mutacin III from group III streptococcus mutans
UA787 and genetic analyses of mutacin III biosynthesis genes
Appl. Environ. Microbiol. 65 (9), 3880-3887 (1999)
PubMed: 10473390




Comment:
For other components see SMu1065 (NBD1); SMu1064 (NBD2) and SMu1064 (MSD2).

For other 'mut' genes see SMu0510 (mutT); SMu0596 (mutF); SMu0597 (mutE); SMu0598 (mutE);SMu0599 (mutG);SMu0099 (mutR);SMu0738 (mutT); SMu0024 (mutT); SMu0976 (mutF);SMu0986 (mutT);SMu0987 (mutT); SMu1050 (mutF); SMu1052 (mutG); SMu1064 (mutT);
SMu1697 (mutY);SMu1700 (mutS2);SMu1291 (mutT); SMu1325 (mutX); SMu1371 (mutR); SMu1468 (mutM); SMu0824 (mutT) and SMu0825 (mutT).


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches weakly in gapped BLAST to ABC transporters:residues 174-552 are 21% similar to the MutT in S.mutans (5918764|).

Residues 5-576 are 30% similar to ABC-transporter transmembrane protein in Y.pestis (16121084|).

The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (4e-53).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379594|ref|NP_721549.1|  putative ABC transporter, ATP-...  1143   0.0  
 gi|125717768|ref|YP_001034901.1|  ABC-type multidrug transpo...   768   0.0  
 gi|157075648|gb|ABV10331.1|  HlyB/MsbA family ABC transporte...   741   0.0  
 gi|42528126|ref|NP_973224.1|  ABC transporter, ATP-binding/p...   603   e-170
 gi|109648198|ref|ZP_01372101.1|  ABC transporter related [De...   572   e-161
 gi|89897487|ref|YP_520974.1|  hypothetical protein DSY4741 [...   570   e-161
 gi|154498165|ref|ZP_02036543.1|  hypothetical protein BACCAP...   553   e-155
 gi|153954137|ref|YP_001394902.1|  Predicted transport protei...   521   e-146
 gi|153955064|ref|YP_001395829.1|  Predicted transport protei...   504   e-141
 gi|42525790|ref|NP_970888.1|  ABC transporter, ATP-binding/p...   501   e-140


InterPro Summary:  InterProScan

InterPro
IPR001140
Domain
ABC transporter, transmembrane region
PF00664 [131-293]T 4.50000034739351E-8 PF00664 ABC_membrane ABC_membrane
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [478-516]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [363-547]T 3.5999885290781605E-53 PF00005 ABC_tran ABC_tran
PS00211 [474-488]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [337-571]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [362-548]T 3.60000000000011E-15 SM00382 AAA AAA
InterPro
IPR011527
Domain
ABC transporter, transmembrane region, type 1
PS50929 [22-305]T 0.0 PS50929 ABC_TM1F ABC_TM1F
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [300-569]T 5.3999701287250304E-70 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19242 [1-586]T 0.0 PTHR19242 PTHR19242 PTHR19242
PTHR19242:SF92 [1-586]T 0.0 PTHR19242:SF92 PTHR19242:SF92 PTHR19242:SF92
SSF52540 [337-576]T 5.6E-65 SSF52540 SSF52540 SSF52540
SSF90123 [1-493]T 4.1E-60 SSF90123 SSF90123 SSF90123


COGS Summary:  COGS Search
BeTs to 12 clades of COG1132
COG name: ABC-type multidrug/protein/lipid transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inX
Number of proteins in this genome belonging to this COG is 16
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2e-56.
    IPB001140A    352-398
    IPB001140B    471-509
    IPB001140C    524-553
***** IPB001984 (ATP-dependent serine proteases, Lon family) with a combined E-value of 3.3e-06.
    IPB001984C    363-399


 ProDom Summary:  Protein Domain Search
Residues 95-346 are 25% similar to a (ATP-BINDING TRANSPORT ABC COMPLETE) protein domain (PD009694 which is seen in Q9EWN8_STRCO.

Residues 353-404 are 63% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in YD48_MYCTU.

Residues 478-516 are 64% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9EWN8_STRCO.


Paralogs:  Local Blast Search
SMu1065 is paralogously related (blast p-value < 1e-3) to SMu1064, SMu0825, SMu0475, SMu0837, SMu0476, SMu0986, SMu1710, SMu0258, SMu0824, SMu0836, SMu0987, SMu1724, SMu0024, SMu0218, SMu0517, SMu1757, SMu0971, SMu0418, SMu1950, SMu1751, SMu0849, SMu1246, SMu1231, SMu1079, SMu1316, SMu0164, SMu0805, SMu1210, SMu1036, SMu0916, SMu0884, SMu0786, SMu1380, SMu0907, SMu1037, SMu1003, SMu1949, SMu1023, SMu1920, SMu1288, SMu0335, SMu0235, SMu1428, SMu0731, SMu0594, SMu1762, SMu1093, SMu1518, SMu1545, SMu0596, SMu1068, SMu1517, SMu0390, SMu0224, SMu1306, SMu0950, SMu1001, SMu0234, SMu0216, SMu1649, SMu0823, SMu1811, SMu1410, SMu0752, SMu0976, SMu0729, SMu0374, SMu1959, SMu0944, SMu0666, SMu1686, SMu1050, and SMu1375 all with ATP binding capabilities .


Pfam Summary:  Pfam Search
Residues 21 to 293 (E-value = 1.2e-07) place SMu1065 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)
Residues 363 to 547 (E-value = 1.2e-54) place SMu1065 in the ABC_tran family which is described as ABC transporter (PF00005)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
21  
37
transmembrane  
63  
79
transmembrane  
137  
153
transmembrane  
162  
178
transmembrane  
248  
264
transmembrane  
280  
296

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MKKKSTMAWISEFIAPYRFHYIASVLLAFASVICGFLPYFYIGRIIRDLF
NGLKNGQLYLQACLWMAVFWLAYAICHALSTALSHRATFIVLADIRFRLT
EKLAKIPLGSVFAQSSGSYKNIIVERVDEAETTLAHIIPEFTASLFGPLI
VLIYMIRLDWRLTLLSLLTLPIGILFYVNMLRKSKGDFENTVVKTKALND
TAVEYINGIEVIKVFGKEKFSYQKFVTAAKEGADCFIDWMRKCQFDMAAV
IVIMPSILAILLPVGAYFVYSGSLSQDNFILLMILSMGLLTPLITLGTYM
DDIRKVGTIFGEITEILEHPDLQRPQELEQPLQGNDILLEKVSFAYEEDK
DVLHDISLTIKSGTVNALVGPSGSGKSTLAKLIASFWDVRTGSISFGGLD
IRKIPLEEYSRLIAYVSQDNFLFNDSILENIRLGKPSASDEEVYQVAKDC
GCYDFIMNLENGFATQVGSSGSSLSGGERQRIAIARAMLKDAPVVILDEA
TAYTDPENEALVQSSIAQLVKDKTLIVIAHRLSTIADADQIILVNEGHIE
AIGKQEDLLKSSDLYQKMWQAHLSVKDADRDEKIGGLAHA

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAGAAAAAATCAACAATGGCTTGGATATCTGAGTTCATTGCACCCTA
TAGATTTCATTATATAGCAAGTGTGCTTTTAGCCTTTGCTTCCGTTATTT
GTGGTTTTCTGCCTTATTTTTATATTGGACGGATTATTCGTGATTTGTTC
AATGGTCTTAAAAATGGGCAGCTTTATTTACAAGCATGTCTGTGGATGGC
TGTTTTTTGGTTGGCTTATGCCATTTGTCATGCTCTATCAACGGCTCTTT
CGCATAGAGCTACTTTTATTGTTTTAGCGGACATTCGTTTTCGTTTAACA
GAAAAATTAGCTAAGATTCCTTTAGGATCTGTCTTTGCGCAATCGTCTGG
ATCCTATAAAAATATTATCGTTGAGCGTGTGGATGAAGCTGAAACAACCC
TAGCTCATATTATTCCAGAATTCACGGCGTCCTTATTTGGTCCTTTAATT
GTTTTAATTTATATGATAAGATTGGATTGGCGTTTGACCCTTTTATCTCT
TTTAACCTTGCCAATCGGCATTTTATTTTATGTCAATATGTTGCGTAAGA
GTAAGGGAGATTTTGAAAATACAGTGGTTAAGACTAAGGCTTTAAATGAT
ACAGCTGTTGAATATATCAATGGCATTGAAGTGATCAAGGTATTTGGAAA
GGAAAAATTTTCCTATCAGAAATTTGTCACAGCAGCTAAAGAAGGAGCTG
ACTGTTTTATTGATTGGATGCGTAAGTGTCAATTTGATATGGCAGCAGTC
ATTGTTATCATGCCTTCGATCTTAGCTATCCTTTTACCTGTTGGTGCTTA
TTTTGTTTACAGTGGCAGTTTATCCCAAGACAATTTCATTTTACTAATGA
TTTTATCAATGGGATTGCTGACGCCTTTGATAACACTGGGAACTTATATG
GATGACATTAGAAAAGTGGGGACCATTTTTGGTGAAATTACGGAAATTTT
GGAACATCCTGATTTACAACGGCCACAAGAATTGGAGCAACCTTTACAAG
GAAACGATATTCTTTTAGAAAAGGTTTCTTTTGCCTATGAAGAGGACAAG
GATGTACTGCATGATATTTCTTTGACCATCAAATCTGGGACAGTTAATGC
CTTGGTCGGTCCTTCTGGCTCTGGGAAGTCCACTTTAGCCAAATTAATTG
CTTCTTTCTGGGATGTTAGAACAGGCAGCATTTCTTTTGGCGGACTTGAT
ATCAGAAAGATTCCACTGGAAGAATACAGTCGGCTGATCGCCTATGTTTC
TCAGGACAATTTTCTCTTTAATGATAGTATTTTAGAGAATATTCGTTTGG
GCAAGCCATCTGCCAGTGATGAAGAGGTTTACCAAGTTGCTAAAGATTGC
GGTTGTTATGATTTTATCATGAATCTTGAAAATGGCTTTGCAACGCAGGT
TGGTAGTTCTGGCAGCAGCCTGTCTGGCGGTGAACGCCAAAGAATAGCCA
TTGCCAGAGCCATGCTAAAGGATGCCCCTGTGGTTATTTTGGATGAAGCG
ACTGCTTATACCGATCCTGAAAATGAAGCTCTGGTACAATCAAGCATTGC
ACAATTAGTGAAAGATAAAACCTTGATTGTGATTGCCCATCGCCTCTCAA
CCATTGCTGATGCAGATCAGATTATTTTAGTAAATGAGGGACATATAGAA
GCAATTGGCAAGCAAGAAGACTTACTCAAGTCAAGCGACCTCTATCAAAA
GATGTGGCAGGCACATTTGTCGGTCAAAGATGCAGACCGTGATGAAAAGA
TAGGAGGCCTGGCTCATGCTTAG

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