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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR853 IGR851 IGR849 IGR850 SMu0988 hemK, - SMu0992 glyA, - SMu0990 SMu0986 SMu0984 pgmA, - SMu0985 SMu0988 hemK, - SMu0992 glyA, - SMu0990 SMu0986 SMu0984 pgmA, - SMu0985 hemK, - SMu0992 glyA, - SMu0990 SMu0986 SMu0991 SMu0989 SMu0987 SMu0991 SMu0989 SMu0987 SMu0988 SMu0984 pgmA, - SMu0985


LANL Gene ID: SMu0987

GenBank Locus Tag: SMU.1079c

DNA Molecule Name:
1  

GenBank ID:
24379516

Gene Name:


Definition:
ABC transporter, ATP-binding / permease protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
1025123

Gene Stop:
1023390

Gene Length:
1734

Molecular Weight*:
65220

pI*:
10.00

Net Charge*:
12.57

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  
Transport and binding proteins; ABC Superfamily: membrane spanning permease  

Gene Ontology:
Biological process
  GO:0006810    transport

Cellular component
  GO:0016021    integral to membrane

Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity
  GO:0042626    ATPase activity, coupled to transmembrane movement of substances


Pathway: pathway table

Primary Evidence:
Qi,F., Chen,P. and Caufield,P.W.
Purification of mutacin III from group III streptococcus mutans
UA787 and genetic analyses of mutacin III biosynthesis genes
Appl. Environ. Microbiol. 65 (9), 3880-3887 (1999)
PubMed: 10473390

Qi,F., Chen,P. and Caufield,P.W.
Functional analyses of the promoters in the lantibiotic mutacin II
biosynthetic locus in Streptococcus mutans
Appl. Environ. Microbiol. 65 (2), 652-658 (1999)
PubMed: 9925596


Comment:
For other components see SMu0986 (NBD1 and MSD1) and SMu0987 (MSD2).




View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC transporter,MutT:residues 1-450 are 96% similar to the previously published protein in S.mutans
(gi4587160).

Residues 1-574 are 55% similar to ABC transporter, ATP-binding / permease protein from S.pneumoniae (gi15901212).Residues 1-565 49% similar to the protein in S.pyogenes (gi15675125).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1071 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379516|ref|NP_721471.1|  putative ABC transporter, ATP-...  1068   0.0  
 gi|125718190|ref|YP_001035323.1|  Multidrug ABC transporter,...   684   0.0  
 gi|157076288|gb|ABV10971.1|  ABC transporter, permease/ATP-b...   679   0.0  
 gi|116627625|ref|YP_820244.1|  ABC-type multidrug transport ...   672   0.0  
 gi|55820822|ref|YP_139264.1|  lipid/multidrug/protein-type A...   672   0.0  
 gi|22537229|ref|NP_688080.1|  ABC transporter, ATP-binding/p...   640   0.0  
 gi|25011154|ref|NP_735549.1|  hypothetical protein gbs1103 [...   639   0.0  
 gi|76788413|ref|YP_329778.1|  ABC transporter, ATP-binding/p...   639   0.0  
 gi|77408669|ref|ZP_00785402.1|  ABC transporter, ATP-binding...   638   0.0  
 gi|77410448|ref|ZP_00786809.1|  ABC transporter, ATP-binding...   637   0.0


InterPro Summary:  InterProScan

InterPro
IPR001140
Domain
ABC transporter, transmembrane region
PF00664 [15-286]T 1.5000030697108698E-30 PF00664 ABC_membrane ABC_membrane
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [470-513]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [359-544]T 4.60000044330908E-48 PF00005 ABC_tran ABC_tran
PS00211 [471-485]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [332-568]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [358-545]T 1.7000000000001E-14 SM00382 AAA AAA
InterPro
IPR011527
Domain
ABC transporter, transmembrane region, type 1
PS50929 [16-298]T 0.0 PS50929 ABC_TM1F ABC_TM1F
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [297-570]T 9.90001804798338E-62 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19242 [1-575]T 0.0 PTHR19242 PTHR19242 PTHR19242
PTHR19242:SF91 [1-575]T 0.0 PTHR19242:SF91 PTHR19242:SF91 PTHR19242:SF91
SSF52540 [331-573]T 2.0000000000000002E-57 SSF52540 SSF52540 SSF52540
SSF90123 [2-320]T 2.9000000000000003E-63 SSF90123 SSF90123 SSF90123


COGS Summary:  COGS Search
BeTs to 12 clades of COG1132
COG name: ABC-type multidrug/protein/lipid transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inX
Number of proteins in this genome belonging to this COG is 16
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 9.5e-48.
    IPB001140A    348-394
    IPB001140B    468-506
    IPB001140C    521-550


 ProDom Summary:  Protein Domain Search
Residues 143-346 are 19% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD010923 which is seen in O52574_SHIFL.

Residues 472-520 are 53% similar to a (ATP-BINDING ABC TRANSPORT TRANSPORTER) protein domain (PD250423 which is seen in Q9ZNB0_STRCO.

Residues 178-256 are 32% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD200991 which is seen in Q9EW98_BBBBB.

Residues 130-314 are 23% similar to a (ATP-BINDING TRANSPORT MG014 TRANSMEMBRANE) protein domain (PD033674 which is seen in Y014_MYCGE.

Residues 469-514 are 58% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459 which is seen in MDR1_LEIEN.

Residues 414-468 are 50% similar to a (ATP-BINDING TRANSPORT TRANSMEMBRANE GLYCOPROTEIN) protein domain (PD000101 which is seen in Q9CIU5_LACLA.

Residues 470-513 are 65% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in YFIB_BACSU.


Paralogs:  Local Blast Search
SMu0987 is paralogously related (blast p-value < 1e-3) to SMu0824, SMu0836, SMu0476, SMu0837, SMu0986, SMu0825, SMu0258, SMu1710, SMu0475, SMu1065, SMu1724, SMu1064, SMu0024, SMu1762, SMu1950, SMu1003, SMu0390, SMu0971, SMu1949, SMu0916, SMu1920, SMu1517, SMu0517, SMu1751, SMu0752, SMu0594, SMu0235, SMu0884, SMu0418, SMu1068, SMu0218, SMu1316, SMu1288, SMu1210, SMu1246, SMu1231, SMu1545, SMu1036, SMu0976, SMu0731, SMu1649, SMu1410, SMu0849, SMu1518, SMu1428, SMu0805, SMu0335, SMu1001, SMu0944, SMu0786, SMu0234, SMu1079, SMu1757, SMu1380, SMu0907, SMu1037, SMu1023, SMu0950, SMu0374, SMu0164, SMu0216, SMu0823, SMu0596, SMu1811, SMu0729, SMu0666, SMu1050, SMu1959, SMu1306, SMu1956, and SMu0224, all with ATP binding capabilities.


Pfam Summary:  Pfam Search
Residues 15 to 286 (E-value = 4.4e-34) place SMu0987 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)
Residues 359 to 544 (E-value = 3.3e-47) place SMu0987 in the ABC_tran family which is described as ABC transporter (PF00005)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
20  
36
transmembrane  
56  
72
transmembrane  
135  
151
transmembrane  
161  
177
transmembrane  
239  
255
transmembrane  
271  
287

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MKSLLIYFKGYLKETILGPVFKLLEASFELLVPLVIAKMVDRYIPHNDKN
HLYLMIFFLVLLACSNITVALIAQYCSAKAAVGYTKQLSQSLFQKIMRLP
KEKRDELTTSSLVTRLVSDTFQIQTGINQFLRLFLRAPIIVFGSVLMAFL
ISPRITIWFFLMIFVLFALVYLMSVVVNPLYDKIRRLTDKIVGLTREQLE
GSRVIRAFGQIKAEEENFQKTNQDYTDWQIKTGYISTLITPLTYLAVNVT
LIVVIWQGQIAISHHYLSQGILIALVNYLLQILVELLKLTMLVSSLNQSF
ISARRITQVFDQEEEDVLAPLQSQLVSDDVLVKVTDMTFSYPQAAKSALE
RISFAVGQGEFFGIIGGTGSGKSSLIQVLLRLYLPQKGNVAIFKDKRSAK
TIKEWRNWVSLVPQKAELFTGTIRSNLLLSTEKQVSDEQLWQVLDIAQAS
DFVNQKPGKLDAQVEAFGRNFSGGQRQRLTIARALLKEAPLLILDDATSA
LDYLTEAKLLQAIKDNFKKTTLIMVSQRTNSLSKADNILVLDQGKQVALA
DHAKLLQTCSLYQEIHYSQHPQEEVVK

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAATCATTACTTATCTATTTTAAGGGGTATCTCAAAGAAACCATACT
TGGCCCCGTCTTCAAACTTTTAGAGGCCTCTTTTGAATTGCTAGTTCCCT
TGGTTATTGCCAAAATGGTTGATCGTTATATTCCTCATAATGATAAAAAT
CATCTTTATTTGATGATTTTCTTTCTGGTTTTATTAGCTTGTTCCAATAT
TACGGTGGCTCTTATTGCCCAATATTGTTCTGCTAAAGCAGCAGTGGGCT
ATACTAAACAGCTTAGTCAAAGTCTTTTTCAAAAAATCATGCGCTTGCCC
AAGGAAAAACGCGATGAATTGACAACGTCAAGTTTAGTGACACGTTTGGT
TAGTGATACCTTTCAAATTCAAACTGGCATTAATCAATTCTTGCGCCTTT
TTCTTAGAGCACCAATTATTGTTTTTGGTTCAGTCTTGATGGCTTTTTTA
ATTAGTCCCAGAATTACCATTTGGTTTTTCCTGATGATTTTTGTCCTTTT
TGCTTTAGTTTATCTCATGTCTGTTGTGGTCAATCCTCTCTATGATAAGA
TTCGCCGTCTAACTGATAAAATTGTTGGTTTAACTCGTGAACAATTAGAA
GGAAGTCGTGTTATTCGTGCTTTTGGTCAAATAAAAGCAGAAGAGGAGAA
TTTTCAAAAAACGAATCAAGATTATACGGATTGGCAAATTAAAACAGGTT
ATATTTCAACCTTAATAACCCCTCTGACCTATTTAGCTGTCAATGTCACC
TTGATTGTTGTCATTTGGCAGGGACAAATTGCTATTTCACATCATTATTT
GAGTCAGGGAATACTAATTGCACTAGTCAATTATTTGCTGCAAATTCTGG
TAGAGCTTTTAAAATTAACGATGTTGGTTTCTTCTTTGAATCAGAGTTTT
ATCAGCGCTAGACGAATCACTCAGGTTTTTGACCAAGAGGAAGAAGATGT
TTTAGCGCCTTTGCAATCTCAACTCGTTTCGGATGATGTCCTTGTTAAAG
TGACAGATATGACTTTTTCCTATCCTCAGGCTGCTAAATCAGCTCTTGAA
AGAATTTCTTTTGCTGTTGGACAAGGAGAATTCTTTGGTATTATTGGCGG
GACTGGTTCTGGAAAGTCTAGTTTAATTCAAGTTCTGTTGCGTCTTTATC
TCCCTCAAAAGGGCAATGTCGCTATTTTTAAGGACAAAAGGAGTGCAAAA
ACCATCAAGGAATGGCGAAATTGGGTTAGTCTGGTTCCTCAAAAGGCAGA
ACTCTTCACAGGAACGATTCGTTCTAACTTGTTGCTTAGTACAGAAAAAC
AAGTCAGTGATGAGCAGCTTTGGCAAGTGCTTGATATAGCTCAGGCTAGC
GATTTTGTTAATCAGAAGCCAGGAAAACTTGATGCCCAAGTAGAAGCCTT
TGGAAGGAATTTTTCAGGCGGACAGAGACAGCGTTTGACTATTGCTAGAG
CTTTATTAAAAGAAGCACCTTTGCTGATACTAGATGACGCCACTTCAGCT
CTTGATTATTTAACAGAAGCAAAACTCTTACAGGCTATCAAGGATAATTT
TAAGAAGACGACACTTATTATGGTATCTCAAAGGACTAACAGTCTTTCTA
AGGCAGATAATATTTTGGTTTTGGATCAAGGAAAGCAAGTGGCATTAGCC
GATCATGCTAAGCTTTTACAAACCTGTTCGCTTTATCAGGAAATTCATTA
CTCGCAACATCCGCAAGAGGAGGTTGTCAAATGA

Los Alamos National Laboratory • Est 1943

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