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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR838 IGR840 IGR835 IGR834 IGR837 IGR836 IGR842 IGR841 IGR839 ylxM, - SMu0969 satC, - SMu0967 busR, - SMu0972 rgrB, - SMu0973 SMu0976 atmD,opuAA, - SMu0971 ffh, - SMu0968 bet,busAB, - SMu0970 guaA, - SMu0974 ylxM, - SMu0969 satC, - SMu0967 busR, - SMu0972 rgrB, - SMu0973 SMu0976 atmD,opuAA, - SMu0971 ffh, - SMu0968 bet,busAB, - SMu0970 guaA, - SMu0974 ylxM, - SMu0969 satC, - SMu0967 busR, - SMu0972 rgrB, - SMu0973 atmD,opuAA, - SMu0971 ffh, - SMu0968 bet,busAB, - SMu0970 SMu0975 SMu0976 SMu0975 guaA, - SMu0974


LANL Gene ID: SMu0971

GenBank Locus Tag: SMU.1063c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
atmD  opuAA  

Definition:
amino acid ABC transporter, ATP-binding protein

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
1008294

Gene Stop:
1007080

Gene Length:
1215

Molecular Weight*:
45022

pI*:
4.90

Net Charge*:
-13.79

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Biological process
  GO:0006865    amino acid transport

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0015171    amino acid transporter activity
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Abranches J, Lemos JA, Burne RA.,
Osmotic stress responses of Streptococcus mutans UA159.
FEMS Microbiol Lett. 2006 Feb;255(2):240-6.
PMID: 16448501

Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. and
Ferretti,J.J.
A binding protein-dependent transport system in Streptococcus
mutans responsible for multiple sugar metabolism
J. Biol. Chem. 267, 4631-4637 (1992)
PubMed: 1537846

Russell RR, Ferretti JJ
Nucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans.
J Gen Microbiol 1990 May;136 ( Pt 5):803-10
PubMed: 2380687
PMID: 2380687

Aduse-Opoku J, Tao L, Ferretti JJ, Russell RR
Biochemical and genetic analysis of Streptococcus mutans alpha-galactosidase.
J Gen Microbiol 1991 Apr;137 ( Pt 4):757-64
PubMed: 1649890
PMID: 1649890

Ferretti JJ, Huang TT, Russell RR
Sequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.
Infect Immun 1988 Jun;56(6):1585-8
PubMed: 2967248
PMID: 2967248

Secondary Evidence:
Obis,D., Guillot,A., Gripon,J.C., Renault,P., Bolotin,A. and
Mistou,M.Y.
Genetic and biochemical characterization of a high-affinity betaine uptake system (BusA) in Lactococcus lactis reveals a new functional organization within bacterial ABC transporters
J. Bacteriol. 181 (20), 6238-6246 (1999)
PubMed: 10515910

Bouvier,J., Bordes,P., Romeo,Y., Fourcans,A., Bouvier,I. and
Gutierrez,C.
Characterization of OpuA, a glycine-betaine uptake system of
Lactococcus lactis
J. Mol. Microbiol. Biotechnol. 2 (2), 199-205 (2000)
PubMed: 10939245



Comment:
For other components see SMu0970 (MSD1).

For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762 (atmD); SMu1002 (atmE); SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA) ; SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to amino acid ABC transport ATP-binding protein:residues 35-283 are 34% similar to the previously published protein in S.mutans (15625431|).

Residues 4-390 are 83% similar to the protein from S.pyogenes (15674388|).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1797 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379500|ref|NP_721455.1|  putative ABC transporter, ATP-...   731   0.0  
 gi|76788093|ref|YP_330415.1|  glycine betaine/proline ABC tr...   620   e-176
 gi|25011878|ref|NP_736273.1|  hypothetical protein gbs1839 [...   619   e-176
 gi|22537936|ref|NP_688787.1|  amino acid ABC transporter, AT...   616   e-175
 gi|15674388|ref|NP_268562.1|  putative glycine betaine/proli...   609   e-172
 gi|94993559|ref|YP_601657.1|  Glycine betaine transport ATP-...   608   e-172
 gi|50913549|ref|YP_059521.1|  Glycine betaine transport ATP-...   607   e-172
 gi|77412018|ref|ZP_00788346.1|  amino acid ABC transporter, ...   590   e-167
 gi|125717255|ref|YP_001034388.1|  Glycine-betaine ABC transp...   575   e-162
 gi|56807720|ref|ZP_00365590.1|  COG4175: ABC-type proline/gl...   572   e-161


InterPro Summary:  InterProScan

InterPro
IPR000644
Domain
Cystathionine-beta-synthase
PF00571 [277-389]T 1.4e-13 PF00571 CBS CBS
SM00116 [342-389]T 4.1 SM00116 CBS CBS
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [163-206]T 1e-16 PD000006 Q8DU84_STRMU_Q8DU84; Q8DU84_STRMU_Q8DU84;
PF00005 [53-240]T 9.4e-69 PF00005 ABC_tran ABC_tran
PS50893 [21-264]T 30.332 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
PS00211 [164-178]T 8e-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [52-249]T 7.3e-19 SM00382 AAA AAA
InterPro
IPR005892
Family
Glycine betaine/L-proline transport ATP-binding subunit
TIGR01186 [35-401]T 1.6e-173 TIGR01186 proV: glycine betaine/L-proline transport A proV: glycine betaine/L-proline transport A
InterPro
IPR013153
Domain
PrkA AAA
SM00763 [9-306]T 2e+02 SM00763 no description no description
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [4-273]T 8e-76 G3DSA:3.40.50.300 no description no description
PTHR19222 [4-13]T 6e-147 PTHR19222 ATP BINDING CASSETE (ABC) TRANSPORTER[38-285]T 6e-147 PTHR19222 ATP BINDING CASSETE (ABC) TRANSPORTER ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF48 [4-13]T 6e-147 PTHR19222:SF48 GLYCINE BETAINE/L-PROLINE ABC TRANSPORTER[38-285]T 6e-147 PTHR19222:SF48 GLYCINE BETAINE/L-PROLINE ABC TRANSPORTER GLYCINE BETAINE/L-PROLINE ABC TRANSPORTER


COGS Summary:  COGS Search
BeTs to 5 clades of COG1125
COG name: ABC-type proline/glycine betaine transport systems, ATPase components
Functional Class: E
The phylogenetic pattern of COG1125 is a-------EBr-uj--o----
Number of proteins in this genome belonging to this COG is 3
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.3e-33.
    IPB001140A    42-88
    IPB001140B    161-199
    IPB001140C    217-246


 ProDom Summary:  Protein Domain Search
Residues 248-390 are 55% similar to a (TRANSPORT ATP-BINDING OPUAA CBS) protein domain (PD021831 which is seen in Q9KIF7_LACLA.

Residues 43-297 are 21% similar to a (C24F3.5) protein domain (PD218211 which is seen in Q21213_CAEEL.

Residues 208-247 are 65% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079 which is seen in Q9HU89_PSEAE.

Residues 134-227 are 35% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424 which is seen in Q9CCF9_MYCLE.

Residues 103-161 are 50% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166 which is seen in Q9RR46_LISMO.

Residues 35-250 are 29% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360 which is seen in Y121_METJA.

Residues 109-161 are 47% similar to a (ATP-BINDING TRANSPORT TRANSPORTER) protein domain (PD052375 which is seen in Y412_METJA.

Residues 208-243 are 55% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472 which is seen in Q9KHT9_LISMO.

Residues 208-247 are 82% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629 which is seen in Q9KIF7_LACLA.

Residues 109-137 are 82% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496 which is seen in Q9KIF7_LACLA.

Residues 43-94 are 67% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9RR46_LISMO.

Residues 163-206 are 97% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9KIF7_LACLA.


Paralogs:  Local Blast Search
SMu0971 is paralogously related (blast p-value < 1e-3) to SMu1920, SMu1003, SMu0884, SMu0849, SMu1762, SMu0517, SMu0805, SMu1428, SMu1380, SMu1950, SMu0731, SMu0418, SMu0218, SMu0594, SMu1288, SMu1246, SMu1231, SMu1068, SMu1517, SMu0235, SMu0786, SMu1036, SMu0916, SMu0234, SMu1751, SMu1210, SMu1079, SMu0390, SMu0258, SMu0335, SMu1518, SMu1710, SMu1949, SMu1037, SMu1757, SMu1001, SMu0907, SMu0944, SMu1316, SMu0752, SMu0950, SMu0825, SMu0374, SMu0976, SMu1023, SMu1065, SMu1724, SMu0824, SMu0476, SMu0216, SMu1064, SMu0836, SMu0475, SMu0837, SMu0987, SMu1649, SMu0596, SMu0986, SMu0024, SMu0164, SMu1545, SMu1050, SMu1410, SMu0666, SMu1093, SMu1959, SMu1811, SMu0224, SMu0729, SMu1306, and SMu0823, all with ATP binding capabilities.


Pfam Summary:  Pfam Search
Residues 53 to 240 (E-value = 1.7e-68) place SMu0971 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 176 3e-045
pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 134 2e-032

Gene Protein Sequence:
MNKLEIKHLTKIFGKKQKAALEMIKEQKSKTEILEKTGATVGVYDVSFDV
KEGEVFVIMGLSGSGKSTLVRLLNRLIEPSSGDVYINGKDIAKMNTEELR
EARRHTLNMVFQNFGLFPHKTILENTEFGLELRGVPKEECIELAERALDN
SNLLAFKDQYPSQLSGGMQQRVGLARALANDPEILLMDEAFSALDPLIRK
EMQDELLDLQEKVQKTIIFITHDLNEALRIGDRIALMKDGQIMQIGTGEE
ILTKPANDFVREFVEDVDRSKVLTAQNIMIKPLTTAVETDGPQVALTRMH
NEEVSMLMATNRRRQLMGSLSAEAAIEARRKGLSLKEAVDPNVRTVSKDT
VITDIMPLIYDSAAPIAVTDDNNRLLGVIIKGRVIEALANTKDDTDTEAE
GEEE

Gene Nucleotide Sequence:  Sequence Viewer
TTGAATAAACTTGAAATAAAACATCTCACCAAAATTTTTGGTAAAAAACA
AAAAGCAGCACTTGAGATGATTAAAGAACAAAAAAGTAAAACGGAAATAC
TTGAAAAAACAGGAGCAACTGTTGGTGTCTATGATGTTAGTTTTGATGTC
AAAGAAGGAGAAGTCTTTGTTATTATGGGGCTCTCTGGATCTGGGAAATC
AACCCTGGTGCGTCTTTTGAATCGTTTGATTGAACCTTCTTCAGGAGATG
TTTATATTAATGGTAAAGACATTGCTAAAATGAATACAGAAGAACTTCGT
GAAGCGAGACGTCACACTCTTAACATGGTTTTTCAAAACTTTGGACTCTT
TCCCCATAAAACAATCTTGGAAAATACAGAATTCGGTTTAGAATTAAGAG
GAGTTCCTAAAGAAGAATGTATTGAATTAGCTGAACGTGCTCTTGATAAT
TCTAATCTTTTAGCTTTTAAAGATCAATATCCTAGTCAGCTGTCTGGAGG
AATGCAGCAACGCGTCGGCTTAGCGCGCGCTCTTGCTAATGATCCAGAAA
TTCTATTGATGGATGAAGCTTTTTCCGCACTTGATCCTTTGATTCGTAAG
GAAATGCAAGATGAGTTGTTAGACTTACAAGAAAAAGTGCAAAAAACGAT
CATTTTCATCACCCACGATTTAAACGAAGCACTTAGAATTGGTGATCGTA
TCGCTCTTATGAAAGATGGTCAAATCATGCAAATAGGTACCGGAGAAGAG
ATCCTAACGAAACCGGCCAATGATTTCGTTCGCGAATTCGTTGAAGATGT
TGATCGTTCTAAAGTTCTAACAGCTCAGAATATTATGATTAAGCCTTTAA
CAACAGCTGTTGAAACAGATGGTCCCCAAGTCGCTCTCACAAGAATGCAT
AATGAGGAAGTTAGTATGTTAATGGCAACTAATCGTCGTCGTCAATTGAT
GGGGTCACTTTCAGCCGAAGCTGCTATTGAGGCCAGACGTAAGGGGCTTT
CTTTAAAGGAGGCCGTTGATCCTAACGTTCGAACTGTTTCTAAAGATACA
GTTATTACGGATATTATGCCTTTAATCTATGATTCTGCTGCACCGATTGC
AGTGACAGATGATAATAATCGTCTATTAGGTGTTATCATTAAAGGTCGAG
TTATTGAAGCTCTCGCTAATACAAAGGATGATACAGATACAGAAGCAGAA
GGAGAGGAAGAATAG

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