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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR516 IGR521 IGR517 IGR515 IGR520 tauC, - SMu0595 SMu0593 SMu0598 SMu0596 mutG, - SMu0599 SMu0600 spaK, - SMu0602 alaS, - SMu0592 tauC, - SMu0595 SMu0593 SMu0598 SMu0596 mutG, - SMu0599 SMu0600 spaK, - SMu0602 alaS, - SMu0592 tauC, - SMu0595 SMu0593 msmK, - SMu0594 msmK, - SMu0594 SMu0596 mutG, - SMu0599 SMu0600 spaK, - SMu0602 alaS, - SMu0592 mutE,ip, - SMu0597 spaR, - SMu0601 spaR, - SMu0601 SMu0598 mutE,ip, - SMu0597


LANL Gene ID: SMu0596

GenBank Locus Tag: SMU.654

DNA Molecule Name:
1  

GenBank ID:
24379127

Gene Name:


Definition:
ABC transporter, ATP-binding protein

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
614935

Gene Stop:
615639

Gene Length:
705

Molecular Weight*:
26006

pI*:
7.30

Net Charge*:
0.69

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Secondary Evidence:
Cvitkovitch DG, Gutierrez JA, Behari J, Youngman PJ, Wetz JE, Crowley PJ, Hillman JD, Brady LJ, Bleiweis AS
Tn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes.
FEMS Microbiol Lett 2000 Jan 1;182(1):149-54
PubMed: 10612747
PMID: 10612747

Comment:
For other components see SMu0598 (MSD1) and SMu0599 (MSD2).




View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to MutF and to other ABC transporters: residues 2-234 are 98% similar to the protein in S.mutans (gi9802352).
Residues 5-228 are 53% similar to ABC transporter (ATP-binding) - lantibiotic associated in S.pyogenes (gi15675073).








The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1980 (3e-36).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379127|ref|NP_721082.1|  putative ABC transporter, ATP-...   442   e-123
 gi|9802352|gb|AAF99691.1|AF267498_1  MutF [Streptococcus mut...   436   e-121
 gi|153931389|ref|YP_001383925.1|  antibiotic ABC transporter...   330   6e-89
 gi|148379548|ref|YP_001254089.1|  lantibiotic ABC transporte...   329   6e-89
 gi|153940363|ref|YP_001390925.1|  antibiotic ABC transporter...   329   8e-89
 gi|28210355|ref|NP_781299.1|  lantibiotic transport ATP-bind...   328   2e-88
 gi|153812110|ref|ZP_01964778.1|  hypothetical protein RUMOBE...   322   1e-86
 gi|47568270|ref|ZP_00238973.1|  bsaF [Bacillus cereus G9241]...   317   5e-85
 gi|154687502|ref|YP_001422663.1|  SpaF [Bacillus amyloliquef...   315   1e-84
 gi|2702246|gb|AAB91597.1|  SpaF [Bacillus subtilis]               314   2e-84


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [129-172]T 2e-17 PD000006 Q9FDH4_STRMU_Q9FDH4; Q9FDH4_STRMU_Q9FDH4;
PF00005 [31-205]T 7.3e-55 PF00005 ABC_tran ABC_tran
PS50893 [6-229]T 21.869 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [30-206]T 6.1e-12 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [3-230]T 1.3e-54 G3DSA:3.40.50.300 no description no description
PTHR19222 [6-213]T 8.2e-87 PTHR19222 ATP BINDING CASSETE (ABC) TRANSPORTER ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF16 [6-213]T 8.2e-87 PTHR19222:SF16 ABC TRANSPORTER ABC TRANSPORTER


COGS Summary:  COGS Search
BeTs to 10 clades of COG1131
COG name: ABC-type multidrug transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--x
Number of proteins in this genome belonging to this COG is 14
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.7e-27.
    IPB001140A    20-66
    IPB001140B    127-165
    IPB001140C    181-210


 ProDom Summary:  Protein Domain Search
Residues 173-226 are 98% similar to a (ATP-BINDING TRANSPORTER COMPLETE PROTEOME) protein domain (PD000174 which is seen in Q9FDH4_STRMU.

Residues 11-205 are 23% similar to a (C24F3.5) protein domain (PD218211 which is seen in Q21213_CAEEL.

Residues 125-205 are 34% similar to a (ABC TRANSPORTER) protein domain (PD058053 which is seen in O69995_STRCO.

Residues 77-128 are 98% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD342138 which is seen in Q9FDH4_STRMU.

Residues 75-172 are 30% similar to a (COSMID C56E6 CG11069) protein domain (PD145750 which is seen in Q9VC15_DROME.

Residues 86-207 are 27% similar to a (LACF) protein domain (PD194047 which is seen in Q9RAV2_LACLA.

Residues 5-74 are 34% similar to a (PROTEOME COMPLETE PM1309) protein domain (PD390268 which is seen in Q9CLC9_PASMU.

Residues 21-69 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9FDH4_STRMU.

Residues 129-172 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9FDH4_STRMU.


Paralogs:  Local Blast Search
SMu0596 is paralogously related (blast p-value < 1e-3) to SMu1649, SMu0944, SMu1050, SMu0216, SMu0335, SMu0390, SMu0950, SMu0976, SMu0374, SMu1380, SMu1093, SMu1003, SMu0849, SMu0218, SMu1518, SMu1950, SMu1023, SMu0731, SMu1079, SMu0884, SMu1920, SMu0666, SMu1410, SMu0517, SMu1517, SMu0418, SMu1210, SMu1762, SMu0594, SMu1288, SMu1428, SMu1037, SMu0805, SMu0164, SMu1949, SMu0971, SMu1246, SMu1231, SMu0907, SMu0916, SMu0476, SMu1068, SMu0235, SMu1751, SMu1036, SMu0786, SMu1316, SMu1064, SMu0752, SMu1545, SMu1001, SMu0825, SMu1306, SMu1959, SMu1757, SMu0836, SMu1065, SMu0986, SMu0234, SMu1710, SMu1724, SMu0824, SMu0258, SMu1811, SMu0837, SMu0823, SMu0987, SMu0024, SMu0224, SMu0475, SMu1202, SMu1686, and SMu0729, all with ATP-binding capabilities.


Pfam Summary:  Pfam Search
Residues 31 to 205 (E-value = 1.1e-51) place SMu0596 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 98 1e-021
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 78 1e-015

Gene Protein Sequence:
MIDYMLETKNLTKQFGKQTAVNQLNLKVERHSIYGLLGPNGSGKSTTLKM
ITGMLRKTSGHILIDGHDWSRKDLENIGALIESPPLYENLTAHENLKVRT
LMLGLPDSRIDEVLKIVDLTNTGKKRAGQFSMGMKQRLGIAIALLNSPQL
LILDEPTNGLDPIGIQELRNLIRSFPTQGITVIISSHILSEIQMTADHIG
IIANGVLGYQDRIHQDEDLEKLFTEVVMKYRGGE

Gene Nucleotide Sequence:  Sequence Viewer
GTGATAGATTATATGCTAGAGACGAAAAATTTAACTAAACAGTTTGGTAA
GCAAACAGCGGTTAACCAATTGAATTTGAAAGTTGAACGTCATTCAATTT
ATGGTTTGCTGGGGCCTAATGGTTCCGGCAAATCAACAACACTTAAAATG
ATTACTGGAATGCTAAGAAAGACATCTGGTCACATTCTTATAGACGGACA
CGATTGGAGCCGCAAGGATTTAGAAAATATCGGGGCTCTGATTGAATCAC
CGCCGCTTTATGAAAACCTGACTGCGCATGAAAATTTAAAGGTAAGAACC
TTGATGCTGGGTTTACCTGATAGTCGCATTGATGAGGTTTTAAAAATAGT
GGATCTAACCAACACGGGTAAAAAAAGAGCAGGGCAATTTTCTATGGGCA
TGAAGCAGCGTCTGGGTATTGCTATCGCACTTTTGAACTCACCTCAACTT
TTGATTCTGGATGAACCGACTAATGGACTTGATCCTATTGGTATTCAGGA
GTTGCGTAATCTTATTCGTTCCTTCCCTACACAAGGAATTACAGTTATTA
TTTCCAGTCATATCTTATCTGAGATTCAGATGACAGCGGATCATATTGGT
ATCATTGCTAATGGCGTACTGGGTTATCAGGATAGAATTCACCAAGATGA
AGACTTGGAAAAACTCTTTACAGAGGTTGTGATGAAATATCGAGGAGGTG
AGTGA

Los Alamos National Laboratory • Est 1943

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