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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1448 IGR1450 IGR1454 IGR1449 IGR1451 IGR1453 IGR1452 nusB, - SMu1680 comEB, - SMu1684 elp,efp, - SMu1682 uvrA, - SMu1686 SMu1688 hdrM, - SMu1690 SMu1683 SMu1687 nusB, - SMu1680 comEB, - SMu1684 elp,efp, - SMu1682 uvrA, - SMu1686 SMu1688 hdrM, - SMu1690 SMu1683 SMu1687 comEB, - SMu1684 elp,efp, - SMu1682 uvrA, - SMu1686 SMu1681 pepP, - SMu1685 pepP, - SMu1685 nusB, - SMu1680 SMu1681 SMu1688 hdrM, - SMu1690 SMu1683 SMu1687 hdrR, - SMu1689 hdrR, - SMu1689


LANL Gene ID: SMu1686

GenBank Locus Tag: SMU.1851c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
uvrA  

Definition:
excinuclease ABC subunit A

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1750808

Gene Stop:
1747977

Gene Length:
2832

Molecular Weight*:
104115

pI*:
6.90

Net Charge*:
-1.65

EC:
3.-.-.-  

Functional Class:
DNA metabolism; DNA replication, recombination, and repair  

Gene Ontology:
Biological process
  GO:0006289    nucleotide-excision repair

Cellular component
  GO:0009380    excinuclease ABC complex

Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0009381    excinuclease ABC activity
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Hanna MN, Ferguson RJ, Li YH, Cvitkovitch DG.
uvrA is an acid-inducible gene involved in the adaptive response to low pH in Streptococcus mutans.
J Bacteriol. 2001 Oct;183(20):5964-73.
PMID: 11566996

Secondary Evidence:
Smith BT, Grossman AD, Walker GC.
Localization of UvrA and effect of DNA damage on the chromosome of Bacillus subtilis.
J Bacteriol. 2002 Jan;184(2):488-93.
PMID: 11751826

Goosen N, Moolenaar GF.
Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair.
Res Microbiol. 2001 Apr-May;152(3-4):401-9. Review.
PMID: 11421287

Comment:
For other 'uvr' genes see SMu0734 (uvrB) and SMu1136 (uvrC).

For the subunit B sequence (uvrB), see SMu0734.
For the subunit C sequence (uvrC) see SMu1136.

View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
This sequence corresponds to the previously published gi1661191 in GenBank. Residues 469-604 are identical to residues 1-136 of gi1661191. Also, residues 1-942 are 85% similar to gi15675653 from S.pyogenes.


The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1709 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380212|ref|NP_722167.1|  excinuclease ABC subunit A [St...  1893   0.0  
 gi|15675653|ref|NP_269827.1|  excinuclease ABC subunit A [St...  1669   0.0  
 gi|28895202|ref|NP_801552.1|  excinuclease ABC subunit A [St...  1669   0.0  
 gi|71904199|ref|YP_281002.1|  excinuclease ABC subunit A [St...  1669   0.0  
 gi|71911363|ref|YP_282913.1|  excinuclease ABC subunit A [St...  1669   0.0  
 gi|21911113|ref|NP_665381.1|  excinuclease ABC subunit A [St...  1668   0.0  
 gi|19746759|ref|NP_607895.1|  excinuclease ABC subunit A [St...  1667   0.0  
 gi|94991126|ref|YP_599226.1|  Excinuclease ABC subunit A [St...  1667   0.0  
 gi|50914885|ref|YP_060857.1|  excinuclease ABC subunit A [St...  1667   0.0  
 gi|94995005|ref|YP_603103.1|  Excinuclease ABC subunit A [St...  1667   0.0


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PF00005 [634-908]T 4.3000017064587896E-29 PF00005 ABC_tran ABC_tran
PS00211 [489-503]T 8.0E-5 PS00211 ABC_TRANSPORTER_1[830-844]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [605-937]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [24-260]T 4.4 SM00382 AAA[633-908]T 1.10000000000001E-5 SM00382 AAA AAA
InterPro
IPR004602
Family
Excinuclease ABC, A subunit
TIGR00630 [4-925]T 0.0 TIGR00630 uvra uvra
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [438-586]T 1.3000006720273E-7 G3DSA:3.40.50.300 G3DSA:3.40.50.300[623-935]T 1.1000015067164302E-21 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [784-927]T 2.19999900980727E-15 PTHR19222 PTHR19222 PTHR19222
SSF52540 [7-571]T 3.3999999999999997E-47 SSF52540 SSF52540[604-934]T 4.2999999999999994E-48 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 13 clades of COG0178
COG name: Excinuclease ATPase subunit
Functional Class: L
The phylogenetic pattern of COG0178 is --t--qvcebrhujgpolinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.4e-13.
    IPB001140A    623-669
    IPB001140C    884-913
    IPB001140A    14-60
    IPB001140C    542-571


 ProDom Summary:  Protein Domain Search
Residues 600-651 are 62% similar to a (ABC EXCINUCLEASE ATP-BINDING SUBUNIT) protein domain (PD002065 which is seen in UVRA_LACLA.

Residues 243-360 are 60% similar to a (ABC EXCINUCLEASE SUBUNIT ATP-BINDING) protein domain (PD003717 which is seen in Q9K6Y0_BACHD.

Residues 133-242 are 69% similar to a (EXCINUCLEASE ABC SUBUNIT ATP-BINDING) protein domain (PD003919 which is seen in UVRA_LACLA.

Residues 343-404 are 41% similar to a (ABC SUBUNIT EXCINUCLEASE ATP-BINDING) protein domain (PD363446 which is seen in Q9KUW5_VIBCH.

Residues 882-936 are 45% similar to a (ABC EXCINUCLEASE ATP-BINDING SUBUNIT) protein domain (PD001721 which is seen in Q9HWG0_PSEAE.

Residues 709-877 are 59% similar to a (ABC EXCINUCLEASE ATP-BINDING SUBUNIT) protein domain (PD001646 which is seen in UVRA_BACSU.

Residues 652-708 are 82% similar to a (EXCINUCLEASE ABC SUBUNIT ATP-BINDING) protein domain (PD003881 which is seen in UVRA_LACLA.

Residues 600-651 are 64% similar to a (EXCINUCLEASE ABC ATP-BINDING SUBUNIT) protein domain (PD407780 which is seen in UVRA_MYCGE.

Residues 361-400 are 55% similar to a (A PROTEOME ATP-BINDING SUBUNIT) protein domain (PD376282 which is seen in Q9K6Y0_BACHD.

Residues 829-875 are 48% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9X7M5_STRCO.

Paralogs:  Local Blast Search
SMu1686 is paralogously related (blast p-value < 1e-3) to SMu1064, SMu0884, SMu0731, SMu0164, SMu0218, SMu1949, SMu1751, SMu1068, SMu0849, SMu0418, SMu1023, SMu1001, SMu1950, SMu1517, SMu0390, SMu1210, SMu1065, SMu0837, SMu0517, SMu1518, SMu0907, SMu1246, SMu1231, SMu0024, SMu1710, SMu0836, SMu0824, SMu0805, SMu0786, SMu1757, SMu1288, SMu0916, SMu0596, SMu1811, SMu0950, SMu1428, SMu1410, SMu1380, SMu1003, and SMu0258, all ABC related elements.


Pfam Summary:  Pfam Search
Residues 25 to 565 (E-value = 4.4e-06) place SMu1686 in the ABC_tran family which is described as ABC transporter (PF00005)
Residues 634 to 905 (E-value = 7.3e-30) place SMu1686 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MQDKLIIRGARAHNLKNIDVEIPRDKLIVMTGLSGSGKSSLAFDTIYAEG
QRRYVESLSAYARQFLGNMDKPDVDSIDGLSPAISIDQKTTSKNPRSTVG
TVTEINDYLRLLYARVGIPYCKNGHGAITASSVEQIVDQVLILPERTRMQ
ILAPVVRRKKGQHKAVFDRIQKDGYVRVRIDGDIMDVAEVPELSKNKMHN
IEVVVDRLVQKDGIRGRLFDSIEAALHLGDGYVIIDTMDDHELIFSEHYS
CPVCGFTVPELEPRLFSFNAPFGSCPTCDGLGIKLEVDLDLVIPDENKTL
REGTLAPWNPISSNYYPQLLEQAMNAFGVDMDKPWKDLSDEDKKLVLHGS
GDTAFHFHYQNDFGGVRDIDIPFEGIISNISRRYHETNSDFTRNVMRSYM
NELPCATCHGYRLNDQALSVRVGGKEGLNIGQVSELSIADHLSLLTHLEL
SENEKTIATPIVKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLA
TQIGSNLSGVLYILDEPSIGLHQRDNDRLISSLKKMRDLGNTLIVVEHDE
DTMMAADWLVDVGPGAGALGGEIVASGTPRQVAKNKKSITGQYLSGKKKI
PVPLDRRKGSGRFIEIKGAAENNLQNINVKFPLGKFIAVTGVSGSGKSTL
VNSILKKVIAQKLNRNSEKPGKYKSISGIEHIDRLIDIDQSPIGRTPRSN
PATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRCEACSGDGIIK
IEMHFLPDVYVPCEVCHGTRYNSETLEVHYKDKNIAEILNMTVNDAAEFF
APIPKIARKIRTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTG
KSFYILDEPTTGLHTDDIARLLKVLERFVDDGNTVLVIEHNLDVIKTADH
IIDLGPEGGVGGGQVIATGTPEQVAEMTESYTGQYLKGRLNEK

Gene Nucleotide Sequence:  Sequence Viewer
ATGCAAGATAAATTAATTATTCGTGGAGCGCGTGCTCATAACTTAAAAAA
TATAGATGTGGAAATTCCGCGTGATAAGTTGATTGTCATGACGGGCTTAT
CGGGTTCAGGAAAGTCCAGTCTGGCTTTTGATACCATTTACGCCGAAGGG
CAACGCCGTTATGTTGAGAGTTTATCGGCTTATGCTAGACAGTTTTTAGG
AAATATGGATAAGCCTGATGTTGATTCGATTGATGGTCTTAGCCCTGCTA
TTTCCATTGACCAAAAGACAACCAGTAAAAATCCACGTTCTACTGTTGGT
ACAGTTACAGAGATTAATGATTATCTCCGATTATTATATGCACGCGTTGG
TATTCCTTATTGTAAAAATGGTCATGGTGCTATCACGGCTTCTTCAGTAG
AGCAGATTGTTGATCAAGTTTTGATCTTGCCTGAGCGGACACGAATGCAG
ATTTTGGCACCTGTTGTTCGGCGGAAAAAAGGTCAACATAAGGCAGTATT
TGATCGCATTCAAAAAGATGGCTATGTTCGTGTGCGTATAGATGGCGACA
TTATGGATGTAGCAGAAGTTCCTGAACTTTCAAAAAATAAAATGCACAAC
ATTGAAGTGGTTGTTGATCGTCTCGTGCAAAAGGATGGTATTAGAGGACG
TTTGTTTGATTCCATTGAAGCAGCTTTGCATTTGGGAGATGGTTATGTCA
TCATTGATACTATGGATGATCATGAATTGATTTTCTCAGAACACTATTCT
TGTCCTGTTTGTGGTTTTACTGTTCCAGAATTGGAACCGCGTCTCTTTTC
TTTTAATGCACCCTTTGGTTCTTGTCCTACCTGTGATGGTTTAGGGATTA
AATTAGAAGTCGATTTGGACTTGGTTATTCCAGATGAGAATAAGACTTTG
AGAGAGGGAACGCTGGCTCCTTGGAATCCTATTTCTTCAAACTATTATCC
GCAGCTATTAGAGCAGGCTATGAATGCTTTTGGTGTAGATATGGATAAAC
CTTGGAAAGATTTATCAGATGAGGATAAAAAACTCGTCTTACATGGTTCA
GGTGACACAGCATTTCATTTTCATTATCAAAATGATTTTGGCGGTGTCAG
GGATATTGATATTCCTTTTGAAGGCATTATTAGCAATATTAGCCGCCGTT
ATCATGAAACTAATAGTGATTTCACACGTAATGTCATGCGCAGCTATATG
AATGAGCTGCCTTGTGCAACCTGTCATGGTTATCGACTCAATGATCAAGC
TCTTAGTGTACGGGTTGGCGGAAAAGAAGGCCTAAATATTGGTCAGGTAT
CTGAGCTATCCATTGCGGATCACTTGAGTTTGCTGACTCATTTGGAACTG
TCAGAAAATGAAAAAACCATTGCAACACCCATTGTCAAGGAAATTAAGGA
TCGTCTGACTTTCCTTAATAATGTGGGTCTTAATTATTTGACTTTATCAC
GCTCAGCAGGAACGCTATCAGGAGGTGAAAGCCAACGCATTCGTCTAGCA
ACTCAGATTGGTTCTAATTTAAGCGGTGTACTTTATATTTTGGATGAACC
TTCCATTGGTTTACATCAAAGAGATAACGACCGCCTTATTTCCAGTCTTA
AGAAAATGCGAGATTTGGGGAATACTTTGATTGTTGTCGAACATGATGAA
GATACCATGATGGCAGCTGATTGGCTGGTTGATGTTGGACCGGGAGCAGG
TGCTTTAGGTGGTGAAATTGTTGCCTCAGGCACCCCAAGGCAAGTTGCTA
AAAATAAAAAGTCTATTACTGGACAGTATTTATCTGGTAAGAAAAAAATT
CCTGTACCTTTGGATCGTCGTAAAGGGAGTGGCCGTTTCATTGAAATCAA
AGGAGCAGCAGAAAACAATCTGCAAAACATTAATGTTAAATTTCCTCTTG
GAAAATTTATTGCCGTTACAGGTGTTTCGGGTTCTGGTAAATCAACACTG
GTTAATAGTATTTTAAAAAAAGTCATTGCTCAAAAACTCAATCGTAATTC
TGAAAAGCCAGGCAAATACAAGTCTATTTCAGGAATTGAACATATTGATC
GTTTAATTGACATTGATCAAAGCCCAATTGGCCGTACACCAAGATCCAAT
CCTGCCACCTATACAGGTGTCTTTGATGATATTCGTGACCTTTTTGCTCA
AACCAATGAAGCTAAAATTCGCGGTTACAAGAAGGGACGTTTTTCTTTCA
ATGTTAAAGGCGGACGCTGCGAAGCCTGCTCAGGTGATGGCATTATCAAA
ATTGAAATGCACTTTTTGCCAGATGTTTATGTGCCTTGTGAAGTCTGTCA
TGGAACGCGTTATAATAGTGAGACTTTGGAAGTTCATTACAAGGACAAAA
ATATTGCAGAAATTCTTAATATGACAGTCAATGACGCAGCAGAATTTTTT
GCACCGATTCCTAAAATTGCTCGCAAGATTCGAACCATTAAGGATGTTGG
TCTGGGTTATGTGACTCTTGGACAGCCAGCGACCACTTTATCAGGTGGGG
AAGCGCAGCGCATGAAGTTGGCTTCTGAACTGCATAAACGCTCAACGGGA
AAGAGTTTTTATATTCTTGATGAGCCTACAACTGGTCTCCATACAGATGA
TATTGCTAGACTTCTTAAAGTCTTAGAGCGCTTTGTTGATGATGGCAATA
CCGTGCTTGTCATTGAGCATAATTTGGACGTTATTAAAACAGCTGACCAT
ATTATTGACTTGGGACCGGAAGGCGGTGTTGGTGGTGGTCAAGTCATAGC
GACTGGGACACCAGAACAAGTAGCTGAGATGACGGAAAGCTATACAGGAC
AGTATTTGAAGGGAAGACTAAATGAAAAATAG

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