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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR823 IGR826 IGR819 IGR820 IGR825 IGR822 IGR824 relA,yjbM, - SMu0955 ycbL,vicR, - SMu0947 ydfG, - SMu0949 waaR,waaJ,kdt, - SMu0948 phoR, - SMu0946 rluE, - SMu0953 pta, - SMu0952 SMu0945 glrA, - SMu0944 SMu0951 relA,yjbM, - SMu0955 ycbL,vicR, - SMu0947 ydfG, - SMu0949 waaR,waaJ,kdt, - SMu0948 phoR, - SMu0946 rluE, - SMu0953 pta, - SMu0952 SMu0945 glrA, - SMu0944 SMu0951 ycbL,vicR, - SMu0947 ydfG, - SMu0949 waaR,waaJ,kdt, - SMu0948 phoR, - SMu0946 rluE, - SMu0953 pta, - SMu0952 ppnK, - SMu0954 ppnK, - SMu0954 relA,yjbM, - SMu0955 glrA, - SMu0944 SMu0951 ecsA,yfiL, - SMu0950 ecsA,yfiL, - SMu0950 SMu0945


LANL Gene ID: SMu0950

GenBank Locus Tag: SMU.1041

DNA Molecule Name:
1  

GenBank ID:
24379479

Gene Name:
ecsA  yfiL  

Definition:
ABC transporter, ATP-binding protein

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
989323

Gene Stop:
990069

Gene Length:
747

Molecular Weight*:
28096

pI*:
4.70

Net Charge*:
-14.10

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Cvitkovitch,D.G., Gutierrez,J.A., Behari,J., Youngman,P.J.,
Wetz,J.E., Crowley,P.J., Hillman,J.D., Brady,L.J.and Bleiweis,A.S.
Tn917-lac mutagenesis of Streptococcus mutans to identify
environmentally regulated genes
FEMS Microbiol. Lett. 182 (1), 149-154 (2000)
PubMed: 10612747

Qi,F., Chen,P. and Caufield,P.W.
Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in streptococcus mutans
Appl. Environ. Microbiol. 65 (2), 652-658 (1999)
PubMed: 9925596


Secondary Evidence:
Yamamoto,H., Uchiyama,S. and Sekiguchi,J.
The Bacillus subtilis chromosome region near 78 degrees contains
the genes encoding a new two-component system, three ABC
transporters and a lipase
Gene 181 (1-2), 147-151 (1996)
PubMed: 8973323


Comment:
For other components see SMu0951 (MSD1 and MSD2).

View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Numerous matches in gapped BLAST to ABC transporter, ATP-binding
proteins.Residues 1-244 are 33% similar to a previously published sequence from S.mutans (3152919|).

Residues 1-243 are 69% similar to 15675537| from
S.pyogenes. Residues 1-241 are 58% similar to 15901235| from
S.pneumoniae





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0280 (1e-99).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379479|ref|NP_721434.1|  putative ABC transporter, ATP-...   491   e-137
 gi|146318402|ref|YP_001198114.1|  ABC-type multidrug transpo...   382   e-104
 gi|81096618|ref|ZP_00874956.1|  ABC transporter [Streptococc...   381   e-104
 gi|146320598|ref|YP_001200309.1|  ABC-type multidrug transpo...   379   e-104
 gi|25010344|ref|NP_734739.1|  hypothetical protein gbs0270 [...   374   e-102
 gi|22536464|ref|NP_687315.1|  ABC transporter, ATP-binding p...   374   e-102
 gi|94991000|ref|YP_599100.1|  ABC transporter ATP-binding pr...   367   e-100
 gi|19746588|ref|NP_607724.1|  putative ABC transporter (ATP-...   367   e-100
 gi|15675537|ref|NP_269711.1|  putative ABC transporter (ATP-...   367   e-100
 gi|94994879|ref|YP_602977.1|  ABC transporter ATP-binding pr...   364   2e-99


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [133-175]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [27-208]T 2.9999875044572E-37 PF00005 ABC_tran ABC_tran
PS00211 [133-147]? 0.0 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [2-232]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [26-208]T 1.30000000000001E-6 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [1-223]T 1.30000495407324E-56 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [2-235]T 2.19999900980727E-78 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF16 [2-235]T 2.19999900980727E-78 PTHR19222:SF16 PTHR19222:SF16 PTHR19222:SF16
SSF52540 [1-222]T 4.999999999999999E-60 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 12 clades of COG1131
COG name: ABC-type multidrug transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--x
Number of proteins in this genome belonging to this COG is 14
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.3e-21.
    IPB001140A    16-62
    IPB001140B    130-168


 ProDom Summary:  Protein Domain Search
Residues 17-220 are 18% similar to a (C24F3.5) protein domain (PD218211 which is seen in Q21213_CAEEL.

Residues 177-218 are 50% similar to a (PROTEOME ATP-BINDING COMPLETE ABC) protein domain (PD403704 which is seen in Q9WZQ0_THEMA.

Residues 182-223 are 57% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174 which is seen in Q9V0K9_PYRAB.

Residues 73-202 are 21% similar to a (AS-48D PLASMID BACE) protein domain (PD034066 which is seen in O53027_ENTFA.

Residues 85-211 are 25% similar to a (LACF) protein domain (PD194047 which is seen in Q9RAV2_LACLA.

Residues 76-218 are 28% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD398054 which is seen in Q9CDL6_LACLA.

Residues 132-175 are 50% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9CE51_LACLA.


Paralogs:  Local Blast Search
SMu0950 is paralogously related (blast p-value < 1e-3) to SMu0374, SMu1649, SMu0944, SMu0596, SMu1003, SMu0976, SMu0335, SMu1093, SMu0216, SMu1518, SMu0418, SMu0884, SMu1950, SMu0731, SMu1920, SMu0390, SMu1050, SMu1762, SMu1517, SMu1210, SMu0666, SMu0517, SMu1380, SMu0971, SMu0218, SMu0907, SMu1949, SMu1410, SMu0594, SMu1428, SMu0849, SMu0235, SMu1079, SMu1288, SMu0475, SMu1710, SMu0805, SMu1023, SMu0258, SMu1757, SMu0234, SMu0752, SMu0916, SMu1036, SMu0164, SMu0836, SMu0786, SMu1001, SMu1068, SMu1959, SMu1037, SMu1246, SMu1231, SMu0476, SMu1064, SMu1065, SMu1811, SMu0825, SMu0987, SMu1751, SMu0837, SMu1724, SMu0986, SMu0024, SMu1316, SMu1545, SMu0823, SMu0729, SMu0224, SMu1686, and SMu1306 all with ATP-binding capabilities.


Pfam Summary:  Pfam Search
Residues 27 to 208 (E-value = 1.6e-41) place SMu0950 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 94 2e-020
pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 76 4e-015

Gene Protein Sequence:
MIRFEHISKIYGTTEALSDLNLTIENGEIFGLIGHNGAGKTTTISLLTSI
IEASYGNIFIDDFKLTEHRDAIKKRIAYVPDSPDIFLNLTAYEYWHFLSK
IYGVEEEIAQERMTKLANLFDISDRQFETIESFSHGMRQKVIVIGALIPN
PDIWILDEPLTGLDPQASYDLKEMMKKHAQDGNTVLFSTHVLSVAEQLCD
RIGILRHGKLIFVGTLEELKANYPNQDLESIYLELAGRKEESKVGDEE

Gene Nucleotide Sequence:  Sequence Viewer
ATGATTAGATTTGAGCATATTTCTAAAATTTATGGAACAACTGAGGCACT
TAGTGACCTTAATTTGACTATAGAAAACGGTGAAATTTTTGGGTTGATTG
GCCATAACGGTGCTGGGAAAACGACGACTATCAGTTTGTTGACATCAATT
ATTGAAGCGAGTTATGGCAATATCTTTATAGATGATTTCAAATTAACAGA
ACATCGTGATGCGATAAAAAAACGAATCGCTTATGTACCTGATTCTCCCG
ATATTTTCCTAAATCTAACAGCTTATGAATATTGGCATTTTCTATCAAAG
ATTTATGGCGTTGAAGAAGAAATTGCCCAAGAGCGAATGACTAAATTAGC
TAACCTTTTTGATATTTCCGATAGACAATTTGAAACCATCGAGAGCTTTT
CACATGGAATGCGACAAAAAGTTATTGTTATTGGTGCTCTCATTCCAAAT
CCAGATATTTGGATTTTAGATGAACCATTGACAGGACTTGACCCACAGGC
CTCTTATGATTTGAAAGAAATGATGAAAAAGCATGCTCAAGATGGCAATA
CGGTCCTCTTTTCAACCCATGTTTTATCAGTTGCTGAACAATTGTGCGAT
CGTATTGGTATTCTTAGACATGGTAAACTTATTTTCGTTGGTACTTTAGA
AGAATTAAAGGCCAATTATCCGAATCAAGATTTAGAAAGTATCTACCTTG
AGTTAGCTGGACGAAAGGAAGAATCAAAGGTAGGTGATGAGGAATGA

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