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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR416 IGR418 IGR415 IGR419 IGR417 IGR420 SMu0479 SMu0481 SMu0477 SMu0480 SMu0474 SMu0478 SMu0473 SMu0471 SMu0475 SMu0479 SMu0481 SMu0477 SMu0480 SMu0474 SMu0478 SMu0473 SMu0471 SMu0475 SMu0479 SMu0481 SMu0477 SMu0480 SMu0474 SMu0478 SMu0473 SMu0475 SMu0472 SMu0476 SMu0476 SMu0471 SMu0472


LANL Gene ID: SMu0476

GenBank Locus Tag: SMU.525

DNA Molecule Name:
1  

GenBank ID:
24379007

Gene Name:


Definition:
ABC transporter ATP-binding / permease protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
492142

Gene Stop:
493884

Gene Length:
1743

Molecular Weight*:
66072

pI*:
6.80

Net Charge*:
-1.40

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  
Transport and binding proteins; ABC Superfamily: membrane spanning permease  

Gene Ontology:
Biological process
  GO:0006810    transport

Cellular component
  GO:0016021    integral to membrane

Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity
  GO:0042626    ATPase activity, coupled to transmembrane movement of substances


Pathway: pathway table

Comment:
For other components see SMu0476 (NBD1); SMu0475 (NBD2) and SMu0475 (MSD2).


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC transporter ATP-binding/membrane spanning proteins. Residues 1-579 are 68% similar to gi15903698 from S.pneumoniae. Residues 3-577 are 44% similar to gi15614898 from B.halodurans.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0461 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379007|ref|NP_720962.1|  putative ABC transporter, ATP-...  1050   0.0  
 gi|25010578|ref|NP_734973.1|  hypothetical protein gbs0508 [...   868   0.0  
 gi|22536640|ref|NP_687491.1|  ABC transporter, ATP-binding/p...   868   0.0  
 gi|55821667|ref|YP_140109.1|  lipid/multidrug/protein-type A...   853   0.0  
 gi|116628378|ref|YP_820997.1|  ABC-type multidrug transport ...   852   0.0  
 gi|148998702|ref|ZP_01826140.1|  ABC transporter, ATP-bindin...   836   0.0  
 gi|149002132|ref|ZP_01827086.1|  ABC transporter, ATP-bindin...   835   0.0  
 gi|15903698|ref|NP_359248.1|  ABC transporter ATP-binding/me...   835   0.0  
 gi|148989632|ref|ZP_01820964.1|  ABC transporter, ATP-bindin...   834   0.0  
 gi|15901668|ref|NP_346272.1|  ABC transporter, ATP-binding/p...   834   0.0


InterPro Summary:  InterProScan

InterPro
IPR001140
Domain
ABC transporter, transmembrane region
PF00664 [25-296]T 2.80000504261125E-29 PF00664 ABC_membrane ABC_membrane
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [477-519]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [367-550]T 1.10000150671643E-47 PF00005 ABC_tran ABC_tran
PS50893 [341-574]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [366-557]T 2.49999999999978E-13 SM00382 AAA AAA
InterPro
IPR011527
Domain
ABC transporter, transmembrane region, type 1
PS50929 [26-308]T 0.0 PS50929 ABC_TM1F ABC_TM1F
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [306-572]T 3.7999735930941604E-69 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19242 [2-575]T 0.0 PTHR19242 PTHR19242 PTHR19242
PTHR19242:SF91 [2-575]T 0.0 PTHR19242:SF91 PTHR19242:SF91 PTHR19242:SF91
SSF52540 [341-579]T 1.0000000000000001E-65 SSF52540 SSF52540 SSF52540
SSF90123 [1-327]T 1.2999999999999999E-73 SSF90123 SSF90123 SSF90123


COGS Summary:  COGS Search
BeTs to 12 clades of COG1132
COG name: ABC-type multidrug/protein/lipid transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inX
Number of proteins in this genome belonging to this COG is 16
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5e-62.
    IPB001140A    356-402
    IPB001140B    474-512
    IPB001140C    527-556


 ProDom Summary:  Protein Domain Search
Residues 524-554 are 77% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383 which is seen in O43121_ASPFU.

Residues 169-239 are 39% similar to a (ATP-BINDING TRANSPORT TRANSMEMBRANE GLYCOPROTEIN) protein domain (PD001096 which is seen in O07549_BACSU.

Residues 523-580 are 40% similar to a (TRANSPORT HOMOLOG ATP-BINDING DRUG) protein domain (PD084250 which is seen in STE6_YEAST.

Residues 160-270 are 24% similar to a (ATP-BINDING MULTIDRUG RESISTANCE-LIKE) protein domain (PD252317 which is seen in MDLB_ECOLI.

Residues 157-251 are 46% similar to a (ATP-BINDING ABC PROTEOME TRANSPORTER) protein domain (PD260448 which is seen in Q9KAF2_BACHD.

Residues 527-577 are 45% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD394504 which is seen in Q9ZIC8_LISMO.

Residues 280-350 are 38% similar to a (ATP-BINDING TRANSPORT TRANSPORTER PEPTIDE) protein domain (PD168165 which is seen in Q9CC89_MYCLE.

Residues 409-474 are 31% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760 which is seen in P73278_SYNY3.

Residues 77-135 are 49% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348 which is seen in Q9KAF2_BACHD.

Residues 277-356 are 41% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818 which is seen in Q9KAF2_BACHD.

Residues 409-476 are 47% similar to a (ABC PROTEOME BINDING COMPLETE) protein domain (PD387933 which is seen in Q9CG38_LACLA.

Residues 277-356 are 32% similar to a (ABC PROTEOME BINDING COMPLETE) protein domain (PD397376 which is seen in Q9CG38_LACLA.

Residues 357-408 are 75% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9CG38_LACLA.

Residues 477-516 are 70% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9CG38_LACLA.


Paralogs:  Local Blast Search
SMu0476 is paralogously related (blast p-value < 1e-3) to SMu0825, SMu0986, SMu0837, SMu0824, SMu0475, SMu0258, SMu0836, SMu1710, SMu1065, SMu0987, SMu1064, SMu1724, SMu1950, SMu0235, SMu1380, SMu0390, SMu0731, SMu1920, SMu0418, SMu0335, SMu0024, SMu1246, SMu1231, SMu0971, SMu0849, SMu1949, SMu0517, SMu1762, SMu1068, SMu1003, SMu1517, SMu1757, SMu1410, SMu1210, SMu0916, SMu0884, SMu0596, SMu1036, SMu0218, SMu0786, SMu1545, SMu1023, SMu1316, SMu1288, SMu0805, SMu1037, SMu1079, SMu0907, SMu1518, SMu1428, SMu0374, SMu0234, SMu0752, SMu0216, SMu0944, SMu1649, SMu0224, SMu0950, SMu1001, SMu1751, SMu0594, SMu0164, SMu0976, SMu1306, SMu1959, SMu1050, SMu1093, SMu1811, SMu1725, SMu0729, SMu0823, SMu1202, and SMu0666, all ABC-related proteins.


Pfam Summary:  Pfam Search
Residues 25 to 296 (E-value = 4.5e-33) place SMu0476 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)
Residues 367 to 550 (E-value = 2.6e-52) place SMu0476 in the ABC_tran family which is described as ABC transporter (PF00005)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
26  
42
transmembrane  
62  
78
transmembrane  
144  
160
transmembrane  
164  
180
transmembrane  
252  
268

Top PDB Hits:
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 68 4e-012
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 67 5e-012

Gene Protein Sequence:
MKNNEHQGHVFWRLMSYLKPYKWLTFFALLFLLSTTVIKSFVPLVASYFI
DHFLTHFNQTAASLLLGYYLLYVLQTILQYFGNLLFARVSFSVVRDIRRD
AFANMERLGMAYFDKTPAGSIVSRLTNDTESISDMFSGILSSFISAIFIF
SVTLYTMLMLNYRLTFLVMLFLPFIFILVNLYRKKSVKVIAKTRSLLSDI
NTNLSESIGGINIIQAFGQEERLKAEFEAINEEHFHYANRSMALDSLFLR
PAMSLLKLLAYALLMAYFGFNWQTIGISAGMMYAFIQYVNRLFDPLIEVT
QNFSTLQTSMVSAGRVFDLIDERDYEPHQDDSDISISAGNIEFRDVSFSY
DGQHQILDHISFKVNQGQTIAFVGPTGSGKSSIINVFMRFYEFQKGQVTI
DGHDIRNYSQEELRKNVGLVLQEPFLYHGTIKSNIKMYQDLTDADIEAAA
KFVDADQFIQKLAHKYEEPVSEGGSSFSTGQRQLMAFARTVASSPKILIL
DEATANIDSETEQLVQNSLAKMRRGRTTIAIAHRLSTIQDANCIYVLDKG
KIIESGTHEELLAKKGTYHKMYQLQAGMMD

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAGAATAATGAACACCAAGGCCATGTTTTTTGGCGTCTGATGTCTTA
TCTTAAGCCCTATAAATGGTTGACTTTCTTCGCCTTGCTTTTCCTTTTGT
CAACAACAGTGATTAAAAGTTTCGTCCCCTTAGTGGCCTCTTATTTTATT
GATCATTTTTTGACTCATTTCAATCAGACAGCAGCTTCACTTTTGCTGGG
CTACTACTTGCTCTATGTTTTGCAGACGATTTTACAATATTTTGGCAATC
TTCTTTTTGCGCGTGTTTCTTTTAGTGTTGTTCGCGACATTCGTAGGGAT
GCCTTTGCCAATATGGAAAGATTGGGAATGGCCTATTTCGATAAAACGCC
AGCAGGTTCGATTGTATCGCGCTTAACCAATGATACAGAAAGTATTAGTG
ACATGTTTTCAGGCATCTTATCTAGTTTTATTTCAGCTATTTTTATTTTT
AGTGTTACCCTTTATACCATGTTAATGCTGAATTATCGCCTAACCTTTCT
TGTCATGCTTTTTTTGCCTTTTATTTTTATTTTGGTCAATCTCTATCGTA
AAAAGTCTGTTAAGGTTATTGCTAAAACGAGGAGTTTATTGAGTGATATC
AATACCAATTTATCTGAAAGTATTGGAGGTATCAATATTATTCAAGCTTT
TGGACAAGAAGAGCGTTTAAAAGCAGAATTTGAGGCAATCAATGAAGAAC
ATTTTCATTATGCCAATCGTTCTATGGCCTTGGACAGTCTTTTCCTACGT
CCAGCTATGTCGCTTTTGAAGCTTTTGGCTTATGCTCTTTTGATGGCTTA
TTTTGGATTTAATTGGCAGACTATTGGTATTTCAGCTGGGATGATGTATG
CCTTTATTCAATATGTTAATCGCCTCTTTGACCCTTTAATTGAAGTGACT
CAGAATTTCTCAACCTTGCAAACTTCTATGGTCTCAGCTGGACGTGTTTT
TGATCTGATAGATGAAAGGGATTATGAACCACATCAAGATGATAGTGACA
TTAGCATTTCAGCTGGTAATATTGAATTTAGGGATGTTTCTTTCTCATAT
GATGGTCAGCATCAAATTTTAGATCATATTTCTTTTAAAGTCAATCAAGG
TCAAACGATTGCTTTTGTTGGTCCAACAGGGTCAGGCAAGTCTTCTATTA
TTAATGTTTTCATGCGCTTTTATGAATTTCAAAAAGGTCAAGTTACCATT
GATGGACATGATATCCGTAACTATAGCCAAGAAGAATTACGCAAAAATGT
TGGTCTGGTTTTGCAAGAGCCCTTCCTTTATCATGGGACAATCAAGTCTA
ATATAAAAATGTATCAGGATTTGACAGATGCGGATATTGAAGCTGCGGCA
AAATTTGTGGATGCTGATCAATTTATTCAAAAATTGGCTCATAAATATGA
GGAACCTGTTAGTGAAGGTGGTTCAAGTTTTTCAACTGGTCAGCGTCAGC
TAATGGCTTTTGCCAGAACGGTAGCAAGTTCGCCTAAAATTTTAATTCTT
GATGAAGCGACAGCTAATATTGACTCAGAAACAGAACAATTGGTTCAAAA
TTCTTTGGCTAAAATGCGTAGAGGACGGACAACCATTGCGATTGCCCATC
GTTTATCAACCATTCAAGATGCCAACTGTATTTATGTTCTTGATAAGGGT
AAAATTATTGAGTCGGGAACTCATGAGGAACTTCTAGCGAAAAAAGGAAC
CTATCACAAAATGTATCAACTCCAAGCAGGTATGATGGATTGA

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