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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR823 IGR819 IGR820 IGR814 IGR816 IGR818 IGR822 IGR824 IGR815 IGR817 IGR813 ycbL,vicR, - SMu0947 ydfG, - SMu0949 waaR,waaJ,kdt, - SMu0948 phoR, - SMu0946 xerC,ymfD, - SMu0943 xis, - SMu0941 SMu0940 SMu0939 SMu0945 ecsA,yfiL, - SMu0950 glrA, - SMu0944 int,int-Tn, - SMu0942 ycbL,vicR, - SMu0947 ydfG, - SMu0949 waaR,waaJ,kdt, - SMu0948 phoR, - SMu0946 xerC,ymfD, - SMu0943 xis, - SMu0941 SMu0940 SMu0939 SMu0945 ecsA,yfiL, - SMu0950 glrA, - SMu0944 int,int-Tn, - SMu0942 Type: tandem, Name: SMu-TR-17 - 17 ycbL,vicR, - SMu0947 ydfG, - SMu0949 waaR,waaJ,kdt, - SMu0948 phoR, - SMu0946 xerC,ymfD, - SMu0943 xis, - SMu0941 SMu0939 SMu0945 ecsA,yfiL, - SMu0950 glrA, - SMu0944 int,int-Tn, - SMu0942 SMu0940


LANL Gene ID: SMu0944

GenBank Locus Tag: SMU.1035

DNA Molecule Name:
1  

GenBank ID:
24379473

Gene Name:
glrA  

Definition:
ABC transporter ATP-binding protein homolog

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
984162

Gene Stop:
985043

Gene Length:
882

Molecular Weight*:
32888

pI*:
8.40

Net Charge*:
3.37

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Cvitkovitch,D.G., Gutierrez,J.A., Behari,J., Youngman,P.J.,
Wetz,J.E.,Crowley,P.J., Hillman,J.D., Brady,L.J.
Tn917-lac mutagenesis of Streptococcus mutans to identify
environmentally regulated genes
FEMS Microbiol. Lett. 182 (1), 149-154 (2000)
PubMed: 10612747

Qi,F., Chen,P. and Caufield,P.W.
Functional analyses of the promoters in the lantibiotic mutacin II
biosynthetic locus in streptococcus mutans
Appl. Environ. Microbiol. 65 (2), 652-658 (1999)
PubMed: NOT_FOUND


Secondary Evidence:
Podlesek,Z., Comino,A., Herzog-Velikonja,B., Zgur-Bertok,D.,
Komel,R. and Grabnar,M.
Bacillus licheniformis bacitracin-resistance ABC transporter:
relationship to mammalian multidrug resistance
Mol. Microbiol. 16 (5), 969-976 (1995)
PubMed: 7476193


Comment:
For other components see SMu0945 (MSD1).

View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC transporter ATP-binding protein homolog. Residues 1-283 are 99% similar to a previously published sequence in S.mutans (gi3152919).

Similar to a mutII mutF from another mutans strain (4322366).

Residues 1-292 are 43% similar to the protein from Clostridium acetobutylicum (gi15894148).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1980 (6e-30).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379473|ref|NP_721428.1|  putative ABC transporter, ATP-...   557   e-157
 gi|3152919|gb|AAC17172.1|  ABC transporter ATP-binding prote...   532   e-150
 gi|157076403|gb|ABV11086.1|  ABC transporter ATP-binding pro...   402   e-110
 gi|125717279|ref|YP_001034412.1|  ABC-type multidrug transpo...   394   e-108
 gi|157075198|gb|ABV09881.1|  ABC transporter ATP-binding pro...   367   e-100
 gi|125717274|ref|YP_001034407.1|  ABC-type multidrug transpo...   362   1e-98
 gi|125717276|ref|YP_001034409.1|  ABC-type multidrug transpo...   348   2e-94
 gi|157075405|gb|ABV10088.1|  ABC transporter ATP-binding pro...   347   6e-94
 gi|156866667|gb|EDO60039.1|  hypothetical protein CLOLEP_028...   246   1e-63
 gi|154483082|ref|ZP_02025530.1|  hypothetical protein EUBVEN...   241   5e-62


InterPro Summary:  InterProScan

InterPro
IPR003006
Family
Immunoglobulin/major histocompatibility complex
PS00290 [91-97]? NA PS00290 IG_MHC IG_MHC
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [125-167]T 6e-17 PD000006 Q8DUA8_STRMU_Q8DUA8; Q8DUA8_STRMU_Q8DUA8;
PF00005 [21-201]T 2.6e-53 PF00005 ABC_tran ABC_tran
PS50893 [1-225]T 18.981 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
PS00211 [125-139]? NA PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [20-205]T 1.2e-08 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [1-216]T 1.9e-50 G3DSA:3.40.50.300 no description no description
PTHR19222 [1-215]T 3.3e-73 PTHR19222 ATP BINDING CASSETE (ABC) TRANSPORTER ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF16 [1-215]T 3.3e-73 PTHR19222:SF16 ABC TRANSPORTER ABC TRANSPORTER


COGS Summary:  COGS Search
BeTs to 11 clades of COG1131
COG name: ABC-type multidrug transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--x
Number of proteins in this genome belonging to this COG is 14
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.3e-23.
    IPB001140A    10-56
    IPB001140B    122-160
    IPB001140C    177-206


 ProDom Summary:  Protein Domain Search
Residues 1-204 are 23% similar to a (C24F3.5) protein domain (PD218211 which is seen in Q21213_CAEEL.

Residues 11-212 are 26% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD313900 which is seen in Q9WZT4_THEMA.

Residues 11-56 are 56% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in O66254_ACTAC.

Residues 125-166 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9KEN4_BACHD.


Paralogs:  Local Blast Search
SMu0944 is paralogously related (blast p-value < 1e-3) to SMu0596, SMu1649, SMu1050, SMu0950, SMu0390, SMu0335, SMu1003, SMu0216, SMu0976, SMu0849, SMu0418, SMu1920, SMu0374, SMu1762, SMu1518, SMu0235, SMu1093, SMu0971, SMu0666, SMu1023, SMu0218, SMu0884, SMu1380, SMu0594, SMu1288, SMu0517, SMu1949, SMu1517, SMu1036, SMu1950, SMu0752, SMu0731, SMu1545, SMu1757, SMu1210, SMu1410, SMu1001, SMu0907, SMu1246, SMu1231, SMu1068, SMu1811, SMu1079, SMu0916, SMu0786, SMu0164, SMu0258, SMu1959, SMu0836, SMu1037, SMu0475, SMu0823, SMu1710, SMu1316, SMu0234, SMu1428, SMu0805, SMu1751, SMu0476, SMu0987, SMu0825, SMu0224, SMu0824, SMu1724, SMu1306, SMu1064, SMu0837, SMu1202, SMu0729, SMu1065, SMu0986, and SMu0024 all with ATP-binding capabilities.


Pfam Summary:  Pfam Search
Residues 21 to 201 (E-value = 6.9e-49) place SMu0944 in the ABC_tran family which is described as ABC transporter (PF00005)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
133  
149

Top PDB Hits:
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 92 8e-020
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 79 6e-016

Gene Protein Sequence:
MSKRYGQQLALDNVNLTIQKGEIYGLIGKNGAGKTTLIKVITKLIQPSQG
SVSVFGSSTQSEWTHALKRVGSVIETPVALNHLTARQNLHYYCKARHVPN
ADKVIDESLTLVGLTNTGKKKFRGFSLGMKQRLGIAIALIVKPDFLILDE
PINGLDPVAIKEFRHMIKKLNEEHDMTVIISSHILSELYQVATKFGIIEN
GRIIKEISKADFDTQSEDYIVLKTSHINEASQILQDQMNYRIKVTNADNE
IHVFGQSHSIKGIVKELVANAVDIDEIYYKRQDLEDYFTQIVE

Gene Nucleotide Sequence:  Sequence Viewer
TTGTCCAAACGATATGGACAACAATTAGCACTTGATAATGTTAATCTTAC
CATTCAAAAAGGTGAGATTTATGGGCTAATTGGTAAAAATGGTGCAGGTA
AGACAACTCTCATCAAAGTCATTACAAAGCTTATTCAACCAAGTCAGGGA
AGTGTTTCAGTCTTTGGTTCTAGCACCCAGAGCGAATGGACACACGCTCT
TAAGCGTGTCGGTTCTGTGATTGAGACACCTGTTGCACTTAATCATTTGA
CTGCCCGACAAAATCTGCACTACTACTGCAAGGCACGGCATGTTCCTAAT
GCTGACAAAGTGATTGACGAAAGTTTAACGCTGGTTGGCCTTACCAATAC
AGGTAAGAAAAAATTTCGTGGTTTTTCACTTGGTATGAAACAGCGTCTGG
GTATAGCTATAGCTTTGATTGTCAAACCAGATTTTCTTATCTTAGACGAA
CCAATTAATGGCTTGGATCCCGTGGCGATCAAAGAATTTCGGCACATGAT
TAAGAAACTTAACGAAGAACACGACATGACAGTGATTATTTCCAGTCATA
TCCTATCTGAGCTTTATCAAGTGGCCACTAAGTTCGGTATTATTGAGAAT
GGTCGTATTATCAAGGAAATTAGCAAGGCTGATTTTGATACCCAAAGCGA
AGACTATATCGTTTTAAAGACCAGTCATATCAATGAAGCCAGCCAAATTC
TTCAGGATCAAATGAATTATCGTATTAAGGTCACTAACGCGGACAATGAA
ATTCATGTGTTCGGACAATCTCATAGTATCAAAGGCATTGTCAAAGAACT
AGTTGCAAATGCTGTTGATATTGACGAAATCTACTACAAACGCCAAGATT
TAGAAGATTACTTCACACAAATTGTAGAATAA

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