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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR715 IGR717 IGR718 IGR719 IGR716 mln, - SMu0826 cca, - SMu0822 SMu0824 SMu0825 ypjG, - SMu0823 gtfD, - SMu0827 mln, - SMu0826 cca, - SMu0822 SMu0824 SMu0825 ypjG, - SMu0823 gtfD, - SMu0827 mln, - SMu0826 cca, - SMu0822 SMu0824 SMu0825 ypjG, - SMu0823 gtfD, - SMu0827


LANL Gene ID: SMu0825

GenBank Locus Tag: SMU.906

DNA Molecule Name:
1  

GenBank ID:
24379356

Gene Name:


Definition:
ABC transporter, ATP-binding / permease protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
861036

Gene Stop:
862808

Gene Length:
1773

Molecular Weight*:
66858

pI*:
6.90

Net Charge*:
-0.37

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: membrane spanning permease  

Gene Ontology:
Biological process
  GO:0006810    transport

Cellular component
  GO:0016021    integral to membrane

Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity
  GO:0042626    ATPase activity, coupled to transmembrane movement of substances


Pathway: pathway table

Primary Evidence:
Qi,F., Chen,P. and Caufield,P.W.
Purification of mutacin III from group III Streptococcus mutans
UA787 and genetic analyses of mutacin III biosynthesis genes
Appl. Environ. Microbiol. 65 (9), 3880-3887 (1999)
PubMed: 10473390

Qi,F., Chen,P. and Caufield,P.W.
Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis Genes
Appl. Environ. Microbiol. 66 (8), 3221-3229 (2000)
PUBMED: 10919773


Comment:
For other components see SMu0825 (NBD1); SMu0824 (NBD2) and SMu0824 (MSD2).





View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC transporter:residues 41-561 are 25% similar to the previously published protein in S.mutans (gi5918764) and (gi9802002).

Several matches in gapped BLAST to ABC transporter, ATP-binding
/permease protein: residues 85-590 are 49% similar to the protein in Clostridium acetobutylicum (gi15896526).Residues 1-580 are 38% similar to the protein from S.pneumoniae (gi15901211).

This sequence is weakly similar to mutT from strain UA140 (see MI0008).







The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379356|ref|NP_721311.1|  putative ABC transporter, ATP-...  1123   0.0  
 gi|25011449|ref|NP_735844.1|  hypothetical protein gbs1407 [...   946   0.0  
 gi|76787704|ref|YP_329978.1|  ABC transporter, ATP-binding/p...   946   0.0  
 gi|22537484|ref|NP_688335.1|  ABC transporter, ATP-binding/p...   945   0.0  
 gi|77411144|ref|ZP_00787496.1|  ABC transporter, ATP-binding...   944   0.0  
 gi|157075980|gb|ABV10663.1|  ABC transporter, permease/ATP-b...   906   0.0  
 gi|125717937|ref|YP_001035070.1|  ABC transporter ATP bindin...   881   0.0  
 gi|81176915|ref|ZP_00875876.1|  ABC transporter, transmembra...   862   0.0  
 gi|55820619|ref|YP_139061.1|  lipid/multidrug/protein-type A...   861   0.0  
 gi|116627426|ref|YP_820045.1|  ABC-type multidrug transport ...   858   0.0


InterPro Summary:  InterProScan

InterPro
IPR001140
Domain
ABC transporter, transmembrane region
PF00664 [21-304]T 8.100007343233421E-44 PF00664 ABC_membrane ABC_membrane
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [485-528]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [375-559]T 7.90003079443043E-56 PF00005 ABC_tran ABC_tran
PS00211 [486-500]? 0.0 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [349-583]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [374-546]T 1.79999999999997E-15 SM00382 AAA AAA
InterPro
IPR011527
Domain
ABC transporter, transmembrane region, type 1
PS50929 [22-316]T 0.0 PS50929 ABC_TM1F ABC_TM1F
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [314-584]T 3.10001307370189E-73 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19242 [7-586]T 0.0 PTHR19242 PTHR19242 PTHR19242
PTHR19242:SF91 [7-586]T 0.0 PTHR19242:SF91 PTHR19242:SF91 PTHR19242:SF91
SSF52540 [349-588]T 9.8E-69 SSF52540 SSF52540 SSF52540
SSF90123 [1-363]T 1.8000000000000003E-82 SSF90123 SSF90123 SSF90123


COGS Summary:  COGS Search
BeTs to 12 clades of COG1132
COG name: ABC-type multidrug/protein/lipid transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inX
Number of proteins in this genome belonging to this COG is 16
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.1e-64.
    IPB001140A    364-410
    IPB001140B    483-521
    IPB001140C    536-565
***** IPB001482 (Bacterial type II secretion system protein E) with a combined E-value of 2.4e-06.
    IPB001482B    374-396


 ProDom Summary:  Protein Domain Search
Residues 530-563 are 73% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383 which is seen in Q9L2F2_STRCO.

Residues 279-500 are 21% similar to a (ABC TRANSPORTER) protein domain (PD241124 which is seen in Q9U0N4_PLAF7.

Residues 15-358 are 18% similar to a (TRANSPORT ATP-BINDING NIST PROTEOME) protein domain (PD018034 which is seen in SPAT_BACSU.

Residues 70-361 are 21% similar to a (ATP-BINDING COMPONENT ABC TRANSPORT) protein domain (PD321417 which is seen in Q9L2K4_STRCO.

Residues 173-280 are 25% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD200980 which is seen in Q9F6W3_CHLAU.

Residues 161-358 are 25% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD168310 which is seen in Q9CAB3_ARATH.

Residues 152-356 are 23% similar to a (ATP-BINDING TRANSPORT MG014 TRANSMEMBRANE) protein domain (PD033674 which is seen in Y014_MYCGE.

Residues 162-264 are 25% similar to a (ATP-BINDING ABC PROTEOME TRANSPORTER) protein domain (PD260448 which is seen in Q9CG37_LACLA.

Residues 13-342 are 20% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD401694 which is seen in Q9CFF6_LACLA.

Residues 536-585 are 42% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD394504 which is seen in YFIB_BACSU.

Residues 14-229 are 19% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD353690 which is seen in Q9KRY4_VIBCH.

Residues 288-358 are 36% similar to a (ATP-BINDING TRANSPORT TRANSPORTER PEPTIDE) protein domain (PD168165 which is seen in Q9CC89_MYCLE.

Residues 417-481 are 36% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760 which is seen in P73278_SYNY3.

Residues 118-335 are 20% similar to a (ATP-BINDING TRANSPORT ABC COMPLETE) protein domain (PD009694 which is seen in Q9CKX7_PASMU.

Residues 209-280 are 44% similar to a (ATP-BINDING ABC TRANSPORTER TRANSMEMBRANE) protein domain (PD348546 which is seen in Q9L2F2_STRCO.

Residues 29-158 are 28% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348 which is seen in Q9KEN7_BACHD.

Residues 283-362 are 38% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818 which is seen in P71082_BACSU.

Residues 3-230 are 20% similar to a (ATP-BINDING PROTEOME PM1473 COMPLETE) protein domain (PD087458 which is seen in Q9CKX8_PASMU.

Residues 417-479 are 38% similar to a (ABC PROTEOME BINDING COMPLETE) protein domain (PD387933 which is seen in Q9CG38_LACLA.

Residues 3-365 are 19% similar to a (LTKB HOMOLOG) protein domain (PD168585 which is seen in O85327_SALTY.

Residues 531-584 are 50% similar to a (ATP-BINDING TRANSPORT MULTIDRUG RESISTANCE-ASSOCIATED) protein domain (PD188719 which is seen in P73400_SYNY3.

Residues 18-276 are 22% similar to a (BELONGS EXPORTER PRODUCT ABC) protein domain (PD119799 which is seen in Q48851_LACSK.

Residues 365-414 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Y288_THEMA.

Residues 170-281 are 27% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD396487 which is seen in Q9CIP5_LACLA.

Residues 485-528 are 81% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9CIU3_LACLA.


Paralogs:  Local Blast Search
SMu0825 is paralogously related (blast p-value < 1e-3) to SMu0837, SMu0986, SMu0476, SMu0475, SMu0824, SMu1710, SMu1065, SMu1064, SMu0258, SMu0836, SMu0987, SMu1724, SMu1950, SMu1380, SMu0024, SMu0418, SMu0971, SMu0517, SMu1762, SMu0731, SMu1210, SMu1920, SMu0805, SMu1079, SMu0916, SMu0235, SMu0390, SMu1003, SMu1023, SMu1949, SMu1246, SMu1231, SMu1316, SMu1545, SMu1410, SMu1757, SMu1037, SMu1036, SMu0849, SMu0335, SMu0594, SMu1428, SMu0786, SMu0218, SMu1288, SMu0216, SMu1518, SMu1068, SMu0224, SMu1649, SMu0884, SMu1751, SMu0374, SMu1517, SMu0596, SMu0907, SMu0976, SMu0234, SMu1001, SMu0164, SMu0944, SMu0950, SMu0823, SMu1306, SMu0752, SMu1811, SMu1093, SMu1050, SMu0666, SMu1959, SMu1202, SMu1725, SMu0729, and SMu1686 all with ATP-binding capabilities.


See also MI0008, a mutacin I transporter in strain UA140.

Pfam Summary:  Pfam Search
Residues 21 to 304 (E-value = 3.8e-47) place SMu0825 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)
Residues 375 to 559 (E-value = 1.1e-57) place SMu0825 in the ABC_tran family which is described as ABC transporter (PF00005)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable  
1  
51
transmembrane  
70  
86
transmembrane  
152  
168
transmembrane  
171  
187
transmembrane  
267  
283
transmembrane  
493  
509

Top PDB Hits:
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 74 4e-014
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 67 7e-012

Gene Protein Sequence:
MKKKTVFLRLWYYLKTYKGSLFLAIFLKILSSVMNVLEPFILGLVMTELT
ANLIDMARGVQGAHLNIRYITMILFLYFLRGLLYSIGSYGSNYFMTNAVQ
KSIYDLRHDLSEKINKIPVSYFDKHQFGDMLGRFTNDVETVSNALQQSFL
QIINAFLTIILVVVMVLYLNLTLAAIILVCIPLTYFSSHFILRKSQPYFK
KQANALGDMNSFVQENLTGFNVIKLYGREEISAETFRTITENLRDVGFKA
SFISGIMMPVLNAISDLAYLIVALVGGLQVLAGRLTIGNMQAFVQYIWQI
NQPIQTITQLSSVLQSAKSSLERIFEVLDETDEVNQVKEKLEHDLTGQVT
FHNVAFQYTEDKPLIRHFDLDVKPGQMIAVVGPTGAGKTTLINLLMRFYD
VTQGAITVDNHDIRNLSRQEYRKQFGMVLQDAWLYEGTIKDNLRFGNLQA
SDEEIVEAAKAANVDHFIRTLPDGYNMEVNQESNNISLGQKQLLTIARAL
LADPKILILDEATSSVDTRLELLIQKAMSKLMEGRTSFVIAHRLSTIQEA
DKILVLKDGQIIEQGNHQSLLADKGFYYDLYMSQFSAKTN

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAAAGAAAACTGTCTTTTTACGCTTATGGTATTATTTGAAAACCTA
TAAAGGTTCACTCTTTTTGGCTATTTTTTTAAAAATACTTAGCAGTGTCA
TGAATGTCCTTGAGCCTTTTATTTTAGGACTGGTAATGACAGAATTAACG
GCTAACTTAATTGATATGGCTCGCGGAGTTCAAGGCGCTCATCTCAATAT
CAGATATATTACCATGATTTTATTTCTTTATTTTTTACGTGGCTTGCTGT
ATAGTATTGGCTCTTACGGTTCTAATTACTTTATGACTAATGCAGTGCAA
AAAAGCATTTACGATTTGCGTCATGATTTGAGTGAAAAGATTAATAAGAT
TCCCGTTTCTTATTTTGATAAACATCAATTTGGCGATATGTTAGGACGTT
TCACTAATGACGTTGAAACAGTCTCCAACGCTTTACAGCAGAGCTTTCTG
CAGATTATTAATGCTTTTTTGACAATTATCCTTGTTGTGGTTATGGTGCT
TTACCTCAATTTGACTCTGGCGGCGATTATTCTTGTTTGTATTCCGCTGA
CTTATTTCAGTTCTCATTTTATTTTAAGGAAATCACAGCCTTATTTTAAA
AAACAGGCTAATGCTTTAGGGGATATGAACAGTTTCGTTCAGGAAAACTT
AACGGGCTTTAATGTCATAAAACTCTATGGACGTGAAGAAATATCTGCTG
AAACCTTTCGAACTATCACAGAAAATTTACGAGATGTCGGCTTTAAAGCC
AGTTTTATTTCTGGAATAATGATGCCAGTTCTTAATGCTATCTCAGACTT
AGCTTATTTGATTGTTGCATTAGTTGGCGGCCTGCAGGTCTTAGCAGGGA
GACTGACTATTGGTAATATGCAGGCCTTTGTTCAATACATTTGGCAAATC
AATCAGCCTATTCAGACCATCACACAATTATCAAGTGTTCTTCAAAGTGC
TAAATCTTCTCTAGAACGTATTTTTGAGGTTTTGGATGAAACAGATGAAG
TCAATCAAGTCAAGGAAAAGCTGGAACATGATTTGACAGGGCAAGTGACC
TTTCATAATGTCGCCTTTCAATATACTGAAGATAAGCCTTTAATTCGACA
TTTTGATTTAGATGTTAAACCGGGTCAGATGATTGCTGTTGTTGGTCCGA
CCGGGGCGGGTAAGACAACTCTTATCAATCTTTTGATGCGTTTTTATGAT
GTTACCCAAGGAGCGATTACAGTAGATAATCATGATATCCGTAACCTTTC
CCGTCAGGAATATCGGAAACAATTTGGGATGGTTCTTCAAGATGCTTGGT
TATATGAAGGGACGATCAAAGACAATTTGCGCTTTGGAAATTTGCAGGCA
AGTGATGAGGAAATTGTCGAAGCAGCCAAGGCAGCTAATGTCGATCATTT
TATCCGAACCCTTCCAGACGGTTATAATATGGAAGTCAATCAAGAATCTA
ATAATATTTCTTTGGGGCAAAAGCAATTGTTAACCATAGCACGAGCGCTG
CTGGCTGATCCCAAAATTCTGATTCTGGATGAAGCGACTTCTTCAGTTGA
TACTCGTTTGGAACTTCTCATTCAAAAAGCTATGAGTAAGCTTATGGAAG
GCCGCACTAGCTTTGTTATTGCTCATCGTCTTTCAACTATCCAAGAAGCC
GATAAGATCCTTGTCCTTAAGGATGGTCAAATTATTGAACAGGGGAACCA
TCAAAGTCTCTTAGCTGACAAGGGCTTCTATTATGATTTGTATATGAGTC
AGTTTAGCGCTAAAACCAATTAG

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