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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR656 IGR653 IGR652 SMu0747 rgpCc, - SMu0751 rmlD, - SMu0748 rgpAc, - SMu0749 rgpDc, - SMu0752 SMu0753 SMu0755 SMu0747 rgpCc, - SMu0751 rmlD, - SMu0748 rgpAc, - SMu0749 rgpDc, - SMu0752 SMu0753 SMu0755 SMu0747 rgpCc, - SMu0751 rmlD, - SMu0748 rgpAc, - SMu0749 rgpDc, - SMu0752 SMu0753 SMu0755 rgpBc, - SMu0750 rgpFc, - SMu0754 rgpBc, - SMu0750 rgpFc, - SMu0754


LANL Gene ID: SMu0752

GenBank Locus Tag: SMU.828

DNA Molecule Name:
1  

GenBank ID:
24379283

Gene Name:
rgpDc  

Definition:
ABC transporter ATP-binding protein

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
773187

Gene Stop:
774404

Gene Length:
1218

Molecular Weight*:
45469

pI*:
4.90

Net Charge*:
-11.14

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.
A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutans
J. Bacteriol. 181 (20), 6556-6559 (1999)
PubMed: 10515952





Secondary Evidence:
Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.
Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.
Infect Immun. 2002 Jun;70(6):2891-8.
PMID: 12010977

Comment:
For other components see SMu0751 (MSD1).

For other 'rgp' genes see SMu0749 (rgpAc);SMu0750 (rgpBc); SMu0751 (rgpCc); SMu0753 (rgpEc) and SMu0754 (rgpFc).

note="involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans"



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC transporter rgpDc: residues 1-405 are 96% similar to the previously published protein in S.mutans (gi7430357). Residues 1-404 are 73% similar to the protein from S.pyogenes (gi15674833).






The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2129 (3e-22).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379283|ref|NP_721238.1|  putative polysaccharide ABC tr...   752   0.0  
 gi|157075156|gb|ABV09839.1|  putative polysaccharide ABC tra...   606   e-172
 gi|55821452|ref|YP_139894.1|  polysaccharide ABC exporter AT...   601   e-170
 gi|15674833|ref|NP_269007.1|  ABC-transporter (ATP-binding p...   583   e-165
 gi|50913969|ref|YP_059941.1|  Polysaccharide export ATP-bind...   583   e-165
 gi|125718318|ref|YP_001035451.1|  ABC-type lipopolysaccharid...   573   e-162
 gi|125623091|ref|YP_001031574.1|  Polysaccharide ABC transpo...   551   e-155
 gi|116511033|ref|YP_808249.1|  ABC-type polysaccharide/polyo...   550   e-155
 gi|15672185|ref|NP_266359.1|  polysaccharide ABC transporter...   548   e-154
 gi|55823379|ref|YP_141820.1|  polysaccharide ABC transporter...   519   e-145


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [152-190]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [57-227]T 6.399986334035939E-35 PF00005 ABC_tran ABC_tran
PS00211 [152-166]? 0.0 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [27-251]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [56-246]T 1.0999999999999402E-12 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [38-243]T 1.2000011745814E-42 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [8-17]T 1.50000965748784E-90 PTHR19222 PTHR19222[42-279]T 1.50000965748784E-90 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF2 [8-17]T 1.50000965748784E-90 PTHR19222:SF2 PTHR19222:SF2[42-279]T 1.50000965748784E-90 PTHR19222:SF2 PTHR19222:SF2 PTHR19222:SF2
SSF52540 [8-275]T 1.8000000000000003E-51 SSF52540 SSF52540 SSF52540
SSF54637 [297-372]T 0.0059 SSF54637 SSF54637 SSF54637


COGS Summary:  COGS Search
BeTs to 6 clades of COG1134
COG name: ABC-type polysaccharide/polyol phosphate transport system, ATPase component
Functional Class: G
The phylogenetic pattern of COG1134 is A----q-C-br---------x
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.7e-24.
    IPB001140A    46-92
    IPB001140B    149-187
    IPB001140C    203-232


 ProDom Summary:  Protein Domain Search
Residues 152-189 are identical to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD002039 which is seen in O82876_STRMU.

Residues 100-150 are identical to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD051171 which is seen in O82876_STRMU.

Residues 199-242 are identical to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174 which is seen in O82876_STRMU.

Residues 270-404 are identical to a (ATP-BINDING PROTEOME COMPLETE) protein domain (PD206495 which is seen in O82876_STRMU.

Residues 4-46 are identical to a (ATP-BINDING PROTEOME COMPLETE) protein domain (PD165914 which is seen in O82876_STRMU.

Residues 46-219 are 27% similar to a (ATP-BINDING POLYSACCHARIDE TRANSPORT) protein domain (PD119675 which is seen in VEXC_SALTI.

Residues 47-97 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in O82876_STRMU.

Residues 152-190 are 64% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q47591_ECOLI.


Paralogs:  Local Blast Search
SMu0752 is paralogously related (blast p-value < 1e-3) to SMu1003, SMu0971, SMu1920, SMu1762, SMu0517, SMu0216, SMu0335, SMu0374, SMu0944, SMu0884, SMu0475, SMu0731, SMu0218, SMu0418, SMu1757, SMu0786, SMu0987, SMu0916, SMu1949, SMu0976, SMu0594, SMu0950, SMu0907, SMu0596, SMu0164, SMu1649, SMu0805, SMu1950, SMu1380, SMu0666, SMu0476, SMu1517, SMu1001, SMu1710, SMu1518, SMu1023, SMu0258, SMu1093, SMu1068, SMu1428, SMu1288, SMu1079, SMu0849, SMu0390, SMu0235, SMu1751, SMu1410, SMu1316, SMu1246, SMu1231, SMu1210, SMu0824, SMu1065, SMu0825, SMu1724, SMu0836, SMu0234, SMu0024, SMu1959, SMu1811, SMu1037, SMu0986, SMu0729, SMu1064, SMu1545, SMu1202, SMu1036, SMu0837, SMu0823, SMu1306, SMu1050, and SMu0224 all with ATP-binding capabilities..


Pfam Summary:  Pfam Search
Residues 57 to 227 (E-value = 2.9e-39) place SMu0752 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 82 1e-016
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 65 1e-011

Gene Protein Sequence:
MTKNNIAVKVDHVSKYFKLPVESTQSLRTALVNRFKGIKGYKKQHVLRDI
DFEVEKGDFFGIVGRNGSGKSTLLKIISQIYVPEQGKVTVDGKLVSFIEL
GVGFNPELTGRENVYMNGAMLGFTTEEVDTMYQDIVDFAELQDFMNQKLK
NYSSGMQVRLAFSVAIKAQGDVLILDEVLAVGDEAFQRKCNDYFLERKNS
GKTTILVTHDMAAVKKYCNKAVLIDDGLIKAIGEPFDVANQYSLDNTDQI
VEDKQEEEAAVQEEEQIVVDNLEVKLLSANRMTPRDSIRFEISYNVLADV
GTYIALSLTDVDRNIWIYNDNSLDYLSSGSGKKRVFYECHLKSLNDIKLK
LEVTVRDKQGQMLAFSSATNTPIISINRDDLEGDDKSAMDSASGLIQRNG
QWQFS

Gene Nucleotide Sequence:  Sequence Viewer
ATGACAAAAAATAATATTGCAGTCAAAGTTGACCATGTCAGTAAGTATTT
TAAGTTACCTGTTGAAAGTACTCAAAGTTTGAGAACTGCCTTAGTCAATC
GTTTTAAAGGGATTAAAGGTTATAAGAAACAGCATGTCCTGCGAGATATT
GATTTCGAAGTTGAAAAAGGAGACTTTTTTGGTATTGTAGGCCGAAATGG
TTCTGGTAAATCAACACTTTTAAAAATTATTTCTCAAATTTATGTTCCTG
AACAAGGCAAAGTTACTGTAGATGGGAAATTAGTTTCTTTTATTGAACTC
GGTGTCGGTTTTAATCCAGAACTGACTGGCCGTGAAAATGTTTATATGAA
TGGGGCTATGCTTGGTTTCACAACTGAAGAGGTAGATACTATGTATCAGG
ATATTGTAGACTTCGCAGAACTTCAAGATTTCATGAATCAAAAGCTGAAA
AACTATTCTAGTGGGATGCAGGTGCGTCTTGCCTTCTCTGTTGCCATAAA
AGCGCAAGGGGATGTCCTCATTCTTGATGAAGTTTTGGCGGTTGGTGATG
AAGCCTTTCAGCGTAAATGTAATGATTACTTTTTGGAAAGAAAGAATAGC
GGCAAGACTACTATCTTGGTAACGCACGATATGGCTGCAGTCAAGAAATA
TTGTAATAAAGCTGTTTTAATAGATGATGGTTTGATAAAGGCAATTGGTG
AGCCATTTGATGTGGCTAACCAATACAGTTTAGATAATACAGACCAGATT
GTTGAGGATAAACAAGAAGAGGAAGCAGCCGTTCAGGAAGAAGAGCAAAT
TGTTGTTGATAATCTTGAAGTAAAACTCCTGTCTGCTAATCGTATGACAC
CAAGAGACTCCATCCGTTTTGAAATTTCTTATAACGTTCTTGCAGATGTG
GGAACATATATTGCTCTTTCTTTGACAGATGTTGATCGTAATATTTGGAT
TTATAATGACAATTCTTTAGACTATCTATCCAGTGGTTCAGGAAAGAAAC
GGGTTTTTTATGAATGCCATCTGAAAAGCTTAAATGATATTAAGTTAAAA
TTGGAAGTGACAGTTAGAGATAAGCAAGGGCAGATGTTGGCTTTTTCTAG
TGCGACAAATACACCTATTATTTCTATTAATCGAGATGACCTTGAAGGTG
ATGACAAATCAGCTATGGACTCTGCCAGTGGACTTATTCAAAGGAATGGG
CAGTGGCAATTTTCATAG

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