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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1421 IGR1413 IGR1420 IGR1414 IGR1422 IGR1418 IGR1415 IGR1419 xerD, - SMu1646 SMu1654 scnR, - SMu1653 scnG, - SMu1647 scnE, - SMu1648 SMu1645 scnF, - SMu1649 scnK, - SMu1652 SMu1651 SMu1644 tpn, - SMu1650 xerD, - SMu1646 SMu1654 scnR, - SMu1653 scnG, - SMu1647 scnE, - SMu1648 SMu1645 scnF, - SMu1649 scnK, - SMu1652 SMu1651 SMu1644 tpn, - SMu1650 xerD, - SMu1646 scnR, - SMu1653 scnG, - SMu1647 scnE, - SMu1648 SMu1645 scnF, - SMu1649 scnK, - SMu1652 SMu1654 SMu1651 SMu1644 tpn, - SMu1650 SMu1643 SMu1643


LANL Gene ID: SMu1649

GenBank Locus Tag: SMU.1811c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
scnF  

Definition:
cdd4-like bacteriocin component, ScnF homolog

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
1710181

Gene Stop:
1709273

Gene Length:
909

Molecular Weight*:
33492

pI*:
4.90

Net Charge*:
-8.78

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:
Bekal-Si Ali S, Hurtubise Y, Lavoie MC, LaPointe G.
Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes.
Gene. 2002 Jan 23;283(1-2):125-31.
PMID: 11867219

Comment:
For other components see SMu1648 (MSD1) and SMu1647 (MSD2).

For other 'scn' genes see SMu1048 (scnR); SMu1647 (scnG);SMu1648 (scnE) ; SMu1652 (scnK) and SMu1653 (scnR).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to cdd4-like scnF homologs. Residues 1-295 are 72% similar to gi7445866 from S.pyogenes. Residues 1-298 are 43% similar to gi7445803 from C.difficile.

Similar to a mutF from a mutacinII strain (4322366).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1980 (4e-30).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380175|ref|NP_722130.1|  putative bacteriocin component...   576   e-163
 gi|113120170|gb|ABI30231.1|  McdF [Streptococcus macedonicus]     453   e-126
 gi|146318548|ref|YP_001198260.1|  ABC-type multidrug transpo...   451   e-125
 gi|81096311|ref|ZP_00874658.1|  ABC transporter [Streptococc...   442   e-123
 gi|2502072|gb|AAB92604.1|  ScnF [Streptococcus pyogenes]          434   e-120
 gi|146320745|ref|YP_001200456.1|  ScnF [Streptococcus suis 9...   429   e-119
 gi|114324660|gb|ABI63642.1|  SboF [Streptococcus salivarius]      361   3e-98
 gi|126698246|ref|YP_001087143.1|  putative lantibiotic ABC t...   244   6e-63
 gi|1770140|emb|CAA63569.1|  cdd4 [Clostridium difficile]          242   2e-62
 gi|145955514|ref|ZP_01804515.1|  hypothetical protein CdifQ_...   242   2e-62


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [133-175]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [30-209]T 9.499968559308538E-48 PF00005 ABC_tran ABC_tran
PS50893 [5-233]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [29-210]T 3.00000000000026E-16 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [4-224]T 6.79998707392899E-54 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [5-223]T 1.0E-83 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF16 [5-223]T 1.0E-83 PTHR19222:SF16 PTHR19222:SF16 PTHR19222:SF16
SSF52540 [4-223]T 1.2E-59 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 10 clades of COG1131
COG name: ABC-type multidrug transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--x
Number of proteins in this genome belonging to this COG is 14
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.2e-20.
    IPB001140A    19-65
    IPB001140B    130-168
    IPB001140C    185-214


 ProDom Summary:  Protein Domain Search
Residues 78-130 are 84% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD342138 which is seen in O31054_STRPY.

Residues 180-217 are 65% similar to a (ATP-BINDING TRANSPORTER COMPLETE PROTEOME) protein domain (PD000174 which is seen in O31054_STRPY.

Residues 25-221 are 22% similar to a (C24F3.5) protein domain (PD218211 which is seen in Q21213_CAEEL.

Residues 88-212 are 28% similar to a (LACF) protein domain (PD194047 which is seen in Q9RAV2_LACLA.

Residues 218-295 are 56% similar to a (SCNF) protein domain (PD057883 which is seen in O31054_STRPY.

Residues 25-68 are 75% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in O31054_STRPY.

Residues 133-175 are 97% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in O31054_STRPY.


Paralogs:  Local Blast Search
SMu1649 is paralogously related (blast p-value < 1e-3) to SMu1050, SMu0596, SMu0944, SMu0335, SMu0950, SMu1003, SMu0976, SMu0666, SMu1518, SMu1410, SMu0216, SMu0374, SMu1093, SMu1762, SMu0418, SMu1023, SMu0517, SMu0390, SMu1210, SMu0218, SMu1920, SMu0884, SMu1079, SMu1517, SMu0731, SMu1949, SMu1380, SMu1950, SMu1428, SMu0235, SMu0849, SMu1316, SMu1068, SMu0594, SMu1751, SMu1036, SMu0971, SMu0786, SMu1288, SMu0805, SMu1811, SMu1246, SMu1231, SMu0916, SMu0825, SMu1001, SMu0907, SMu1710, SMu0164, SMu0752, SMu0258, SMu0234, SMu1757, SMu1037, SMu0987, SMu0224, SMu0476, SMu1545, SMu0475, SMu0986, SMu1064, SMu1959, SMu0837, SMu1065, SMu0836, SMu0824, SMu1724, SMu1306, SMu0024, SMu0823, and SMu0729, all ATP-binding proteins.


Pfam Summary:  Pfam Search
Residues 30 to 209 (E-value = 6.5e-49) place SMu1649 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 98 2e-021
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 74 3e-014

Gene Protein Sequence:
MDNVIELQNLTKVYNGVTTVDLKKITVHQGEIYGFLGPNGAGKTTTMKMI
LSLIAPTSGNVLVNDSNIKKDVAYLDQIGSMIEEPSYYPNLTGYENLLVF
QKMLSFDKNNIWPTLELVGLADEKNTKKLVKAYSLGMKQRLALAFALVKR
PKILLLDEPTNGLDPAGIHEIRELIVTLAKEKGLTVFISSHILSEIEHIA
DRVGIINHGRLVYEGAIEAIQSNAWIEIGGDFSTGDITTALNEYGLVRVL
DIAANKLTLGDFSNNDLADFVTYLVEKGFRIFRVVRETETLEDIFLNLTT
EV

Gene Nucleotide Sequence:  Sequence Viewer
ATGGACAATGTTATTGAACTACAGAATTTAACAAAGGTATACAATGGTGT
GACGACAGTAGACCTTAAAAAGATTACTGTGCATCAGGGGGAAATATATG
GTTTTCTTGGGCCAAATGGTGCTGGTAAGACAACAACGATGAAGATGATT
TTGTCACTTATTGCACCAACTTCAGGAAACGTTTTAGTGAATGACAGTAA
TATCAAGAAAGATGTCGCTTACTTGGATCAAATTGGTTCCATGATTGAAG
AGCCATCTTATTATCCTAACCTGACTGGTTATGAAAATCTTTTAGTATTT
CAAAAAATGCTTAGTTTTGATAAAAATAATATTTGGCCAACGCTGGAACT
TGTCGGATTAGCAGATGAGAAAAACACGAAGAAACTTGTTAAAGCCTATT
CCCTAGGAATGAAGCAACGCTTAGCTTTAGCGTTTGCATTGGTGAAAAGG
CCAAAAATCTTACTGTTGGATGAACCAACTAATGGTCTGGATCCTGCAGG
TATTCATGAGATTCGGGAGTTGATTGTAACACTGGCGAAAGAGAAGGGGC
TGACAGTATTTATTTCTAGCCATATCTTGTCTGAGATTGAGCATATTGCA
GATCGTGTGGGCATTATTAACCACGGTCGTCTCGTCTATGAGGGAGCGAT
TGAAGCGATTCAGTCCAATGCTTGGATTGAGATTGGCGGCGATTTTTCAA
CAGGCGATATCACGACAGCTCTAAATGAATATGGATTAGTTAGGGTTCTT
GATATAGCAGCCAATAAATTAACCTTGGGCGATTTTTCCAATAACGACTT
AGCAGACTTTGTCACCTATTTGGTAGAAAAAGGCTTTCGCATTTTTAGAG
TTGTTCGTGAGACAGAGACTCTTGAAGACATTTTCCTTAATTTAACAACG
GAGGTTTGA

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