Basic Search | Intermediate Search | Gene Image Map |  Home

Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR892 IGR893 IGR891 IGR890 IGR888 IGR894 IGR895 IGR889 SMu1033 phoU, - SMu1035 ciaR,gcrR, - SMu1032 pstB,atmD, - SMu1036 pstB, - SMu1037 pstS, - SMu1040 pstC, - SMu1039 yebU, - SMu1041 pepN, - SMu1034 SMu1033 phoU, - SMu1035 ciaR,gcrR, - SMu1032 pstB,atmD, - SMu1036 pstB, - SMu1037 pstS, - SMu1040 pstC, - SMu1039 yebU, - SMu1041 pepN, - SMu1034 phoU, - SMu1035 ciaR,gcrR, - SMu1032 pstB,atmD, - SMu1036 pstB, - SMu1037 pstS, - SMu1040 pstC, - SMu1039 yebU, - SMu1041 pepN, - SMu1034 pstC, - SMu1038 pstC, - SMu1038 SMu1033


LANL Gene ID: SMu1036

GenBank Locus Tag: SMU.1134c

DNA Molecule Name:
1  

GenBank ID:
24379565

Gene Name:
pstB  atmD  

Definition:
phosphate ABC transporter, ATP-binding protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
1076361

Gene Stop:
1075603

Gene Length:
759

Molecular Weight*:
28046

pI*:
8.40

Net Charge*:
1.68

EC:
3.6.3.27  

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Biological process
  GO:0006817    phosphate transport

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0000166    nucleotide binding
  GO:0005315    inorganic phosphate transporter activity
  GO:0005524    ATP binding
  GO:0015114    phosphate transporter activity
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table
ABC transporters - General

Primary Evidence:
Russell RR, Aduse-Opoku J, Sutcliffe IC, Tao L, Ferretti JJ
A binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism.
J Biol Chem 1992 Mar 5;267(7):4631-7
PubMed: 1537846
PMID: 1537846

Novak,J., Caufield,P.W. and Miller,E.J.
Isolation and biochemical characterization of a novel lantibiotic
mutacin from Streptococcus mutans
J. Bacteriol. 176 (14), 4316-4320 (1994)
PubMed: 8021218

Qi,F., Chen,P. and Caufield,P.W.
Functional analyses of the promoters in the lantibiotic mutacin II
biosynthetic locus in Streptococcus mutans
Appl. Environ. Microbiol. 65 (2), 652-658 (1999)
PubMed: 9925596

Russell,R.R.B. and Ferretti,J.J.
Nucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans
J. Gen. Microbiol. 136, 803-810 (1990)
PubMed: 2380687

Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.
Sequence analysis of the glucosyltransferase A (gtfA) gene from
Streptococcus mutans Ingbritt
Infect. Immun. 56, 1585-1588 (1988)
PubMed: 2967248

Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.
Biochemical and genetic analysis of Streptococcus mutans
alpha-galactosidase
J. Gen. Microbiol. 137, 757-764 (1991)
PubMed: 1649890


Comment:
For other components see SMu1037 (NBD1); SMu1038 (MSD1); SMu1039 (MSD2) and SMu1040 (SBP1).

For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762 (atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).

For other 'pst' genes see SMu1002 (pstC) ; SMu1037 (pstB);SMu1038 (pstC); SMu1039 (pstC) and SMu1040 (pstS).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to phosphate ABC transporter, ATP-binding protein:residues 1-247 are 35% similar to the previously published AtmD in S.mutans (gi15625431).

Residues 1-252 are 83% similar to phosphate ABC transporter, ATP-binding protein in S.pneumoniae (gi15901250).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0988 (1e-126).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379565|ref|NP_721520.1|  putative phosphate ABC transpo...   500   e-140
 gi|22537148|ref|NP_687999.1|  phosphate ABC transporter, ATP...   445   e-123
 gi|81177366|ref|ZP_00876197.1|  ABC transporter [Streptococc...   441   e-122
 gi|125717784|ref|YP_001034917.1|  Phosphate import ATP-bindi...   439   e-121
 gi|148985650|ref|ZP_01818804.1|  phosphate ABC transporter, ...   435   e-120
 gi|157075972|gb|ABV10655.1|  Phosphate import ATP-binding pr...   435   e-120
 gi|15901250|ref|NP_345854.1|  phosphate ABC transporter, ATP...   433   e-120
 gi|55821038|ref|YP_139480.1|  phosphate ABC uptake transport...   429   e-119
 gi|116627797|ref|YP_820416.1|  ABC-type phosphate transport ...   429   e-119
 gi|15675201|ref|NP_269375.1|  phosphate ABC transporter (ATP...   425   e-117


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [149-191]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [31-223]T 8.500030248090482E-50 PF00005 ABC_tran ABC_tran
PS00211 [149-163]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [6-247]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [30-223]T 3.90000000000001E-12 SM00382 AAA AAA
InterPro
IPR005670
Family
Phosphate transport system permease protein 1
PTHR19222:SF24 [6-250]T 1.30000495407264E-121 PTHR19222:SF24 Phosp_transpt1 Phosp_transpt1
TIGR00972 [5-252]T 0.0 TIGR00972 3a0107s01c2 3a0107s01c2
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [3-247]T 1.7000029559006503E-60 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [6-250]T 1.30000495407264E-121 PTHR19222 PTHR19222 PTHR19222
SSF52540 [4-239]T 5.200000000000001E-61 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 11 clades of COG1117
COG name: ABC-type phosphate transport system, ATPase component
Functional Class: P
The phylogenetic pattern of COG1117 is amt--qvCeBRh--gpo----
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.2e-30.
    IPB001140A    20-66
    IPB001140B    146-184


 ProDom Summary:  Protein Domain Search
Residues 194-250 are 64% similar to a (ATP-BINDING TRANSPORT PHOSPHATE PROTEOME) protein domain (PD006546 which is seen in Q9CEW8_LACLA.

Residues 199-248 are 56% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD255463 which is seen in Q9X4T3_STRPN.

Residues 149-198 are 48% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459 which is seen in MDR1_LEIEN.

Residues 88-118 are 74% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496 which is seen in O67154_AQUAE.

Residues 21-74 are 66% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9CEW8_LACLA.

Residues 149-191 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9CEW8_LACLA.


Paralogs:  Local Blast Search
SMu1036 is paralogously related (blast p-value < 1e-3) to SMu1037, SMu0517, SMu0731, SMu0218, SMu1380, SMu1762, SMu0418, SMu1920, SMu0971, SMu0849, SMu1003, SMu0594, SMu0234, SMu1517, SMu0235, SMu1950, SMu1288, SMu1079, SMu1949, SMu1210, SMu0884, SMu0335, SMu1757, SMu1068, SMu1724, SMu1710, SMu0258, SMu0944, SMu0216, SMu0916, SMu1649, SMu1518, SMu0390, SMu0805, SMu0164, SMu0475, SMu1001, SMu0825, SMu1428, SMu1065, SMu0986, SMu1811, SMu1246, SMu1231, SMu0476, SMu1064, SMu0836, SMu0824, SMu1751, SMu0950, SMu0596, SMu1410, SMu0224, SMu1316, SMu0837, SMu0907, SMu0786, SMu0987, SMu0374, SMu1023, SMu1050, SMu1093, SMu1959, SMu1306, SMu0024, SMu0976, SMu0823, SMu0666, SMu0729, SMu1545, and SMu0752, all with ATP binding capabilities.


Pfam Summary:  Pfam Search
Residues 31 to 223 (E-value = 1.6e-54) place SMu1036 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 128 8e-031
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 85 1e-017

Gene Protein Sequence:
MTEPILKVNDLSVYYGKKKALHSVSIDFYPNEITSLIGPSGSGKSTLLRA
INRMGDLNPEVTVTGSIIYNGHNIYSRRTDTVELRKEIGMVFQQPNPFPM
TIYENVVYGLRLKGVKDKKILDEAVEKSLVGASIWDEVKDRLHDSAIGLS
GGQQQRVCIARVLATSPKIILLDEPTSALDPISAGKIEDTLYGLKEKYTM
LVVTRSMQQASRISNRTGFFLAGDLVEYGNTKEMFMNPQKQETEDYITGK
FG

Gene Nucleotide Sequence:  Sequence Viewer
ATGACAGAACCTATTTTAAAAGTAAACGATCTTTCTGTTTACTATGGTAA
AAAGAAGGCCCTTCATAGTGTATCTATTGATTTTTATCCTAATGAAATCA
CTTCGTTAATTGGGCCATCAGGATCTGGTAAGTCAACTTTGTTACGTGCT
ATCAATAGAATGGGTGATCTAAATCCCGAGGTGACAGTTACAGGTTCGAT
TATATATAATGGTCACAATATCTACAGCCGTCGAACAGATACAGTTGAAT
TACGTAAGGAAATTGGTATGGTTTTCCAGCAGCCTAACCCTTTTCCAATG
ACTATTTATGAAAATGTTGTTTACGGTCTTCGTTTAAAAGGTGTTAAAGA
TAAGAAAATTTTGGATGAAGCTGTTGAAAAATCTTTGGTAGGTGCTTCCA
TTTGGGATGAGGTTAAAGACCGTCTACATGATTCAGCAATTGGTTTATCA
GGAGGACAGCAGCAACGTGTTTGTATTGCTAGAGTGTTAGCAACAAGCCC
TAAGATTATTTTGTTAGATGAACCAACTTCAGCCTTAGATCCTATTTCAG
CAGGAAAAATTGAGGATACACTTTATGGTTTGAAAGAAAAATATACAATG
CTTGTGGTGACACGTTCAATGCAGCAAGCTTCACGTATTTCTAATCGTAC
GGGATTTTTCTTAGCTGGTGATTTGGTAGAATATGGAAATACCAAAGAAA
TGTTTATGAATCCGCAAAAGCAAGAAACCGAAGACTATATTACAGGTAAG
TTTGGATAG

Los Alamos National Laboratory • Est 1943

Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy