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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR190 IGR188 IGR189 IGR191 IGR187 IGR192 IGR194 SMu0217 ycdC, - SMu0214 SMu0218 drrB, - SMu0215 SMu0219 SMu0213 ilvC, - SMu0211 ilvA, - SMu0212 SMu0220 SMu0217 ycdC, - SMu0214 SMu0218 drrB, - SMu0215 SMu0219 SMu0213 ilvC, - SMu0211 ilvA, - SMu0212 SMu0220 SMu0217 ycdC, - SMu0214 SMu0218 drrB, - SMu0215 SMu0219 SMu0216 SMu0216 SMu0213 ilvC, - SMu0211 ilvA, - SMu0212 SMu0220


LANL Gene ID: SMu0216

GenBank Locus Tag: SMU.238c

DNA Molecule Name:
1  

GenBank ID:
24378748

Gene Name:


Definition:
ABC transporter, ATP-binding protein

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
227416

Gene Stop:
226697

Gene Length:
720

Molecular Weight*:
26229

pI*:
5.40

Net Charge*:
-6.30

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Primary Evidence:

Qi,F., Chen,P. and Caufield,P.W.
Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis Genes
Appl. Environ. Microbiol. 66 (8), 3221-3229 (2000)
PUBMED: 10919773



Comment:
For other components see SMu0215 (MSD1).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC ATPbinding elements, e.g. residues 1-235 are 47% similar to 15672236 from L.lactis lactis. Residues 2-238 are 48% similar to 16799995 from L.inocua.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0260 (1e-88).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378748|ref|NP_720703.1|  putative ABC transporter, ATP-...   451   e-125
 gi|77407085|ref|ZP_00784087.1|  ABC transporter, ATP-binding...   310   6e-83
 gi|22536444|ref|NP_687295.1|  ABC transporter, ATP-binding p...   309   7e-83
 gi|25010326|ref|NP_734721.1|  hypothetical protein gbs0252 [...   308   2e-82
 gi|76788565|ref|YP_328986.1|  ABC transporter, ATP-binding p...   307   3e-82
 gi|77409859|ref|ZP_00786491.1|  ABC transporter, ATP-binding...   307   4e-82
 gi|90961202|ref|YP_535118.1|  ABC transporter, ATP-binding p...   298   2e-79
 gi|116333523|ref|YP_795050.1|  ABC-type multidrug transport ...   296   1e-78
 gi|92088905|ref|ZP_01273861.1|  ABC transporter related [Lac...   293   5e-78
 gi|116493409|ref|YP_805144.1|  ABC-type multidrug transport ...   288   1e-76


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [134-176]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [30-208]T 4.60000044330908E-45 PF00005 ABC_tran ABC_tran
PS00211 [134-148]? 0.0 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [5-232]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [29-217]T 4.30000000000003E-10 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [2-219]T 3.5999885290781605E-53 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [5-234]T 2.5999823391029002E-80 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF16 [5-234]T 2.5999823391029002E-80 PTHR19222:SF16 PTHR19222:SF16 PTHR19222:SF16
SSF52540 [4-221]T 2.2000000000000004E-61 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 9 clades of COG1131
COG name: ABC-type multidrug transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--x
Number of proteins in this genome belonging to this COG is 14
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.1e-27.
    IPB001140A    19-65
    IPB001140B    131-169
    IPB001140C    185-214
***** IPB001324 (Phosphoribulokinase family) with a combined E-value of 6.5e-06.
    IPB001324A    29-50


 ProDom Summary:  Protein Domain Search
Residues 4-211 are 22% similar to a (C24F3.5) protein domain (PD218211 which is seen in Q21213_CAEEL.

Residues 68-173 are 34% similar to a (CG5944 NUCB1) protein domain (PD335045 which is seen in Q9VVK7_DROME.

Residues 86-211 are 33% similar to a (LACF) protein domain (PD194047 which is seen in Q9RAV2_LACLA.

Residues 78-176 are 29% similar to a (REPEAT AMV130 CG1494 CG8473) protein domain (PD328804 which is seen in Q9V912_DROME.

Residues 15-210 are 28% similar to a (ATP-BINDING POLYSACCHARIDE TRANSPORT) protein domain (PD119675 which is seen in VEXC_SALTI.

Residues 69-132 are 42% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD386448 which is seen in Q9CIV2_LACLA.

Residues 20-68 are 51% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9ZK44_HELPJ.

Residues 134-173 are 72% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9FLT5_ARATH.


Paralogs:  Local Blast Search
SMu0216 is paralogously related (blast p-value < 1e-3) to SMu0596 (a MutF previously published in GenBank as gi|9802352), SMu0335, SMu0390, SMu1079, SMu1649, SMu1380, SMu0950, SMu1410, SMu0944, SMu1003, SMu0884, SMu0218, SMu0374, SMu1950, SMu0976, SMu0849, SMu0517, SMu1093, SMu1068, SMu0418, SMu0666, SMu0731, SMu1949, SMu1210, SMu1246, SMu1231, SMu0594, SMu0164, SMu1518, SMu1050, SMu1428, SMu0786, SMu1517, SMu0805, SMu0971, SMu1288, SMu0752, SMu0234, SMu1920, SMu1751, SMu1036, SMu0916, SMu0475, SMu1757, SMu1762, SMu1023, SMu0825, SMu1811, SMu0224, SMu0235, SMu0907, SMu1306, SMu1037, SMu0258, SMu0476, SMu1545, SMu1710, SMu1316, SMu1001, SMu1959, SMu1064, SMu0986, SMu0824, SMu1065, SMu0836, SMu0837, SMu0987, SMu1724, SMu0823, SMu0024, SMu0729, and SMu1686, all with ATP-binding capabiities.


Pfam Summary:  Pfam Search
Residues 30 to 208 (E-value = 2.9e-55) place SMu0216 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 98 1e-021
pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 87 2e-018

Gene Protein Sequence:
MEKLLDLQAIRKNFGHQVILNNINFSLDAGEIIGLIGPSGAGKSTMIKTM
LGMEKADEGEALVLNHHMPNRHILGEIGYMAQSDALYETLSGLENMEFFA
QMKGLTKIEIPQAIDHATQVVDLSEHLNKSVAGYSGGMKRRLSLAIALLG
NPRLLILDEPTVGIDPALRRKVWKELRQLKKDGVGILVTTHVMDEAELTD
KVGLLLDGKIMAFDSPNNLKSIYAVDTIEDVFLKAEGEL

Gene Nucleotide Sequence:  Sequence Viewer
ATGGAAAAATTACTAGATTTACAAGCTATTCGAAAAAATTTTGGTCATCA
AGTTATCCTTAACAATATTAATTTCAGTTTGGATGCTGGTGAAATTATTG
GCTTGATTGGTCCATCCGGTGCCGGAAAATCAACTATGATTAAAACCATG
CTTGGAATGGAAAAGGCAGATGAAGGGGAAGCACTCGTTCTCAACCATCA
TATGCCAAATCGGCATATCTTAGGAGAAATCGGCTACATGGCACAATCCG
ATGCGCTTTACGAAACACTTTCTGGTTTGGAAAATATGGAATTTTTTGCT
CAAATGAAGGGCTTAACTAAAATAGAGATTCCCCAAGCCATTGATCACGC
TACCCAAGTTGTTGATTTATCCGAACATCTTAATAAGTCAGTTGCGGGTT
ATTCGGGAGGAATGAAGCGCCGTCTATCTTTAGCTATTGCCCTTCTGGGA
AATCCCAGACTCCTTATTCTTGACGAACCAACTGTTGGTATTGATCCCGC
ATTGCGTCGCAAAGTCTGGAAAGAGCTACGCCAATTAAAAAAAGATGGTG
TAGGTATTTTAGTTACAACACACGTTATGGATGAAGCTGAATTAACAGAT
AAGGTTGGCTTATTACTAGATGGAAAAATTATGGCTTTTGATAGTCCAAA
TAATTTAAAATCCATCTATGCTGTTGATACTATTGAAGATGTTTTCTTGA
AGGCAGAAGGAGAATTATGA

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