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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR468 IGR465 IGR464 IGR472 IGR470 IGR469 IGR466 IGR467 IGR471 SMu0547 pyrD, - SMu0542 SMu0541 furR,spf, - SMu0540 recR, - SMu0545 gpmA,pmgY, - SMu0543 SMu0548 ddlA, - SMu0546 murF, - SMu0549 pbp2b, - SMu0544 SMu0547 pyrD, - SMu0542 SMu0541 furR,spf, - SMu0540 recR, - SMu0545 gpmA,pmgY, - SMu0543 SMu0548 ddlA, - SMu0546 murF, - SMu0549 pbp2b, - SMu0544 SMu0547 pyrD, - SMu0542 furR,spf, - SMu0540 recR, - SMu0545 gpmA,pmgY, - SMu0543 SMu0548 ddlA, - SMu0546 murF, - SMu0549 pbp2b, - SMu0544 SMu0541


LANL Gene ID: SMu0545

GenBank Locus Tag: SMU.598

DNA Molecule Name:
1  

Genomic Island ID:
9

GenBank ID:
24379076

 Gene Name:
recR  

 Definition:
recombination protein

 Cellular Location:
Cytoplasm [Evidence]

 Gene Start:
556993

Gene Stop:
557592

Gene Length:
600

Molecular Weight*:
21804

pI*:
4.80

Net Charge*:
-8.22

EC:
 

 Functional Class:
DNA metabolism; DNA replication, recombination, and repair  

 Gene Ontology:
Biological process
  GO:0006281    DNA repair
  GO:0006304    DNA modification
  GO:0006310    DNA recombination

Cellular component
  GO:0005622    intracellular

Molecular function
  GO:0003676    nucleic acid binding
  GO:0043565    sequence-specific DNA binding


 Pathway: pathway table

 Secondary Evidence:
Alonso,J.C., Shirahige,K. and Ogasawara,N.
Molecular cloning, genetic characterization and DNA sequence
analysis of the recM region of Bacillus subtilis
Nucleic Acids Res. 18 (23), 6771-6777 (1990)
PubMed: 2124672




 Comment:
For other 'rec' genes see SMu0021 (recO);SMu0532 (recN); SMu1956 (recF); SMu1892 (recA); SMu0425 (recU) ; SMu1669 (recG); SMu1705 (recD) and SMu1339 (recJ).

From Genbank [gi:3024524].
This protein may play a role in DNA repair.It seems to be involved in an REDBC-independent recombinational process of DNA repair.It may act with RECF and RECO.



 View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
Several matches in gapped BLAST to recombination proteins: residues 1-199 are 87% similar to the enzyme in S.pyogenes (gi15675339) and are 84% similar to the protein from S.pneumoniae (gi6634573).






The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0766 (2e-98).


 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379076|ref|NP_721031.1|  recombination protein RecR [St...   385   e-106
 gi|94994663|ref|YP_602761.1|  Recombination protein recR [St...   350   3e-95
 gi|50914532|ref|YP_060504.1|  recombination protein RecR [St...   349   4e-95
 gi|15675339|ref|NP_269513.1|  recombination protein RecR [St...   346   3e-94
 gi|125717544|ref|YP_001034677.1|  Recombinational DNA repair...   346   5e-94
 gi|157075805|gb|ABV10488.1|  recombination protein RecR [Str...   346   5e-94
 gi|139473554|ref|YP_001128270.1|  recombination protein RecR...   343   5e-93
 gi|22536930|ref|NP_687781.1|  recombination protein RecR [St...   342   5e-93
 gi|55820693|ref|YP_139135.1|  recombination protein RecR [St...   340   3e-92
 gi|116627502|ref|YP_820121.1|  Recombinational DNA repair pr...   338   8e-92


InterPro Summary:  InterProScan

InterPro
IPR000093
Family
RecR protein
PF02132 [38-79]T 1.7999975402237798E-19 PF02132 RecR RecR
TIGR00615 [1-197]T 9.16998862870318E-125 TIGR00615 recR recR
PS01300 [57-78]T 8.0E-5 PS01300 RECR RECR
InterPro
IPR003583
Domain
Helix-hairpin-helix DNA-binding, class 1
SM00278 [12-31]T 0.33 SM00278 HhH1 HhH1
InterPro
IPR006154
Domain
Toprim subdomain
SM00493 [80-166]T 1.1999999999999299E-14 SM00493 TOPRIM TOPRIM
InterPro
IPR006171
Domain
TOPRIM
PF01751 [80-174]T 7.000007341299071E-14 PF01751 Toprim Toprim
noIPR
unintegrated
unintegrated
SSF111304 [1-199]T 2.800000000000001E-72 SSF111304 SSF111304 SSF111304


COGS Summary:  COGS Search
BeTs to 9 clades of COG0353
COG name: Recombinational DNA repair protein
Functional Class: L
The phylogenetic pattern of COG0353 is -----q-cebrhuj---linx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB000093 (RecR putative zinc finger) with a combined E-value of 1.6e-98.
    IPB000093A    18-68
    IPB000093B    77-117
    IPB000093C    128-157
    IPB000093D    166-196


 ProDom Summary:  Protein Domain Search
Residues 35-199 are 89% similar to a (RECOMBINATION DNA REPAIR ZINC-FINGER) protein domain (PD006826 which is seen in RECR_STRTR.

Residues 1-34 are 91% similar to a (RECOMBINATION DNA REPAIR ZINC-FINGER) protein domain (PD099651 which is seen in Q9RCP8_STRPN.


Paralogs:  Local Blast Search
SMu0545 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 38 to 79 (E-value = 1.6e-22) place SMu0545 in the RecR family which is described as RecR protein (PF02132)
Residues 80 to 174 (E-value = 1.2e-16) place SMu0545 in the Toprim family which is described as Toprim domain (PF01751)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MLYPTPIAKLIESFTKLPGIGIKTATRLAFYTIGMSDEDVNNFAKNLLAA
KRELTYCSVCGNLTDDDPCNICTDESRDRSTVLVVEDSKDVSAMEKIQEY
HGLYHVLHGLISPMNGIGPDDINLKSLLTRLRDNSDIHEVIIATNATADG
EATAMYISRVLKPAGITVTRLARGLAVGSDIEYADEVTLLRAIENRTEL

Gene Nucleotide Sequence:  Sequence Viewer
ATGCTCTACCCAACGCCTATTGCCAAACTTATTGAGAGCTTCACAAAATT
ACCGGGTATTGGTATCAAAACAGCGACTCGCTTAGCTTTTTATACGATTG
GTATGAGTGATGAAGACGTTAATAACTTTGCTAAAAATCTTCTAGCTGCT
AAACGAGAATTGACCTACTGTTCTGTTTGTGGCAATCTGACAGATGATGA
TCCTTGCAATATTTGTACAGATGAAAGCAGAGACCGCTCGACTGTTTTAG
TAGTTGAAGATAGTAAGGATGTTTCTGCAATGGAAAAAATTCAGGAATAT
CATGGTCTTTATCATGTTTTACACGGCCTGATTTCTCCTATGAATGGTAT
TGGTCCTGATGATATTAATTTGAAAAGTCTTCTGACACGCCTACGTGATA
ATAGTGATATTCATGAAGTCATTATCGCAACTAATGCCACAGCAGATGGA
GAAGCAACGGCTATGTATATTTCCAGAGTTCTCAAACCTGCTGGTATTAC
AGTTACACGTTTAGCGCGTGGGCTTGCTGTTGGTTCTGACATTGAGTATG
CTGATGAAGTAACTCTGCTTCGAGCAATTGAAAACAGGACAGAGTTATAA

Los Alamos National Laboratory • Est 1943

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