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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR231 IGR228 IGR229 IGR232 IGR234 IGR230 IGR233 IGR227 SMu0257 SMu0255 SMu0256 comB, - SMu0259 SMu0261 SMu0260 tkt,tktA, - SMu0262 comA, - SMu0258 SMu0257 SMu0255 SMu0256 comB, - SMu0259 SMu0261 SMu0260 tkt,tktA, - SMu0262 comA, - SMu0258 SMu0256 comB, - SMu0259 SMu0261 SMu0260 tkt,tktA, - SMu0262 comA, - SMu0258 SMu0255 SMu0257


LANL Gene ID: SMu0259

GenBank Locus Tag: SMU.287

DNA Molecule Name:
1  

GenBank ID:
24378791

Gene Name:
comB  

Definition:
ABC transport protein ComB, accessory factor for ComA

Cellular Location:
Periplasm, Membrane, Cytoplasm, Extracellular [Evidence]

Gene Start:
272924

Gene Stop:
273826

Gene Length:
903

Molecular Weight*:
34103

pI*:
10.60

Net Charge*:
27.88

EC:
 

Functional Class:
Cellular processes; Competence  
Transport and binding proteins; ABC Superfamily: substrate-binding protein  

Gene Ontology:

Pathway: pathway table

Secondary Evidence:
Lunsford,R.D. and London,J.
Natural genetic transformation in Streptococcus gordonii: comX
imparts spontaneous competence on strain wicky
J. Bacteriol. 178 (19), 5831-5835 (1996)
PubMed: 8824638


Comment:
For other components see SMu0258 (NBD1) and (MSD1).

For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Limited matches in gapped BLAST to hypotheticals and BlpC ABC transporters. Residues 1-100 and 166-280 are 46% and 51% similar resp. to stretches of gi15900443 in S.pneumoniae. Weaker similarities over these fragments correspond to the predicted comB protein of S.gordonii (gi1698422).





SMu0259 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378791|ref|NP_720746.1|  putative ComB, accessory facto...   412   e-113
 gi|24380252|ref|NP_722207.1|  hypothetical protein SMU.1900 ...   172   3e-41
 gi|149002202|ref|ZP_01827144.1|  BlpC ABC transporter [Strep...   137   1e-30
 gi|148994812|ref|ZP_01823867.1|  hypothetical protein CGSSp9...   136   1e-30
 gi|149005644|ref|ZP_01829383.1|  BlpC ABC transporter [Strep...   136   1e-30
 gi|15900443|ref|NP_345047.1|  BlpC ABC transporter [Streptoc...   136   2e-30
 gi|148998207|ref|ZP_01825676.1|  BlpC ABC transporter [Strep...   136   2e-30
 gi|149012592|ref|ZP_01833589.1|  BlpC ABC transporter [Strep...   135   3e-30
 gi|148990051|ref|ZP_01821305.1|  BlpC ABC transporter [Strep...   135   3e-30
 gi|15902510|ref|NP_358060.1|  Conserved hypothetical protein...   135   4e-30


InterPro Summary:  InterProScan

noIPR
unintegrated
unintegrated
signalp [1-41]? NA signalp signal-peptide signal-peptide
tmhmm [21-41]? NA tmhmm transmembrane_regions transmembrane_regions


COGS Summary:  COGS Search
No hits to the COGs database.
Blocks Summary:  Blocks Search
***** IPB002215 (HlyD family secretion protein) with a combined E-value of 2.2e-12.
    IPB002215A    56-92
    IPB002215B    160-194
    IPB002215C    272-294


 ProDom Summary:  Protein Domain Search
Residues 166-240 are 53% similar to a (TRANSPORT ACCESSORY TRANSMEMBRANE) protein domain (PD007371 which is seen in Q9EU69_STRPN.

Residues 1-78 are 44% similar to a (TRANSPORT SECRETION ABC TRANSMEMBRANE) protein domain (PD225235 which is seen in Q9EU69_STRPN.


Paralogs:  Local Blast Search
SMu0259 is paralogously related (blast p-value < 1e-3) to SMu1726, and SMu0431, both conserved hypotheticals.


Pfam Summary:  Pfam Search
No significant hits to the Pfam 11.0 database

 Structural Feature(s):
Feature Type  Start  Stop
cleavable  
1  
41

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MDPKFLQSAEFYRRRYHNFATLLIVPLVCLIIFLVIFLCFAKKEITVIST
GEVAPTKVVDVIQSYSDSSIIKNNLDNNAAVEKGDVLIEYSENASPNRQT
EQKNIIKERQKREEKEKKKHQKSKKKKKSKSKKASKDKKKKSKDKESSSD
DENETKKVSIFASEDGIIHTNPKYDGANIIPKQTEIAQIYPDIQKTRKVL
ITYYASSDDVVSMKKGQTARLSLEKKGNDKVVIEGKINNVASSATTTKKG
NLFKVTAKVKVSKKNSKLIKYGMTGKTVTVIDKKTYFDYFKDKLLHKMDN


Gene Nucleotide Sequence:  Sequence Viewer
ATGGATCCTAAATTTTTACAAAGTGCAGAATTTTATAGGAGACGCTATCA
TAATTTTGCGACACTATTAATTGTTCCTTTGGTCTGCTTGATTATCTTCT
TGGTCATATTCCTTTGTTTTGCTAAAAAAGAAATTACAGTGATTTCTACT
GGTGAAGTTGCACCAACAAAGGTTGTAGATGTTATCCAATCTTACAGTGA
CAGTTCAATCATTAAAAATAATTTAGATAATAATGCAGCTGTTGAGAAGG
GAGACGTTTTAATTGAATATTCAGAAAATGCCAGTCCAAACCGTCAGACT
GAACAAAAGAATATTATAAAAGAAAGACAAAAACGAGAAGAGAAGGAAAA
GAAAAAACACCAAAAGAGCAAGAAAAAGAAGAAGTCTAAGAGCAAGAAAG
CTTCCAAAGATAAGAAAAAGAAATCGAAAGACAAGGAAAGCAGCTCTGAC
GATGAAAATGAGACAAAAAAGGTTTCGATTTTTGCTTCAGAAGATGGTAT
TATTCATACCAATCCCAAATATGATGGTGCCAATATTATTCCGAAGCAAA
CCGAGATTGCTCAAATCTATCCTGATATTCAAAAAACAAGAAAAGTGTTA
ATCACCTATTATGCTTCTTCTGATGATGTTGTTTCTATGAAAAAGGGGCA
AACCGCTCGTCTTTCCTTGGAAAAAAAGGGAAATGACAAGGTTGTTATTG
AAGGAAAAATTAACAATGTCGCTTCATCAGCAACTACTACTAAAAAAGGA
AATCTCTTTAAGGTTACTGCCAAAGTAAAGGTTTCTAAGAAAAATAGCAA
ACTCATCAAGTATGGTATGACAGGCAAGACAGTCACTGTCATTGATAAAA
AGACTTATTTTGATTATTTCAAAGATAAATTACTGCATAAAATGGATAAT
TAG

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