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| Estimating the Extent of the Health Hazard Posed by High-Production Volume Chemicals Albert R. Cunningham and Herbert S. Rosenkranz Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Abstract
We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals. Key words: high production volume (HPV) chemicals, prevalence, structure-activity relationships, toxicity. Environ Health Perspect 109:953-956 (2001) . [Online 5 September 2001] http://ehpnet1.niehs.nih.gov/docs/2001/109p953-956cunningham/ abstract.html Address correspondence to A.R. Cunningham, Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238 USA. Telephone: (412) 967-6544. Fax: (412) 624-1020. E-mail: acunningham@server.ceoh.pitt.edu We gratefully acknowledge the support of the Vira Heinz Endowment. Received 17 October 2000 ; accepted 14 March 2001.
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