References
Abarbanel J, Shabtai F, Kyzer S, Chaimof C. 1991. Cytogenetic studies in patients with gastric cancer. World J Surg 15:778-782.
Albertini RJ, Anderson D, Douglas GR, Hagmar L, Hemminki K, Merlo F, et al. 2000. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety. Mutat Res 463: 111-172.
Barrios L, Caballin MR, Miro R, Fuster C, Berrozpe G, Subias A, et al. 1988. Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability. Hum Genet 78:320-324.
Barrios L, Caballin MR, Miro R, Fuster C, Guedea F, Subias A, et al. 1991. Chromosomal instability in breast cancer patients. Hum Genet 88:39-41.
Bavorova H, Ocadlikova D, Cirkova J, Hola N. 1989. Methods for biological monitoring of genotoxic effects of environmental factors. Acta Hyg Epidemiol Microbiol 20: 3-15.
Bonassi S, Abbondandolo A, Camurri L, Dal Pra L, De Ferrari M, Degrassi F, et al. 1995. Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet Cytogenet 79:133-135.
Bonassi S, Hagmar L, Stromberg U, Montagud AH, Tinnerberg H, Forni A, et al. 2000. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. European Study Group on Cytogenetic Biomarkers and Health. Cancer Res 60:1619-1625.
Bonassi S, Ugolini D, Kirsch-Volders M, Strömberg U, Vermeulen R, Tucker JD. 2005. Human population studies with cytogenetic biomarkers: review of the literature and future prospectives. Environ Mol Mutagen. doi: 10.1002/em.20115 [Online 1 February 2005]
Bonassi S, Znaor A, Norppa H, Hagmar L. 2004. Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective. Cytogenet Genome Res 104: 376-382.
Bryant PE. 1998. Mechanisms of radiation-induced chromatid breaks. Mutat Res 404: 107-111.
Caporaso N, Greene MH, Tsai S, Pickle LW, Mulvihill JJ. 1987. Cytogenetics in hereditary malignant melanoma and dysplastic nevus syndrome: is dysplastic nevus syndrome a chromosome instability disorder? Cancer Genet Cytogenet 24:299-314.
Carrano AV, Natarajan AT. 1988. International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques. Mutat Res 204:379-406.
Cheng KC, Loeb LA. 1993. Genomic instability and tumor progression: mechanistic considerations. Adv Cancer Res 60:121-156.
Cox DR, Oakes D. 1990. Analysis of Survival Data. London:Chapman & Hall.
Dave BJ, Hopwood VL, King TM, Jiang H, Spitz MR, Pathak S, et al. 1995. Genetic susceptibility to lung cancer as determined by lymphocytic chromosome analysis. Cancer Epidemiol Biomarkers Prev 4:743-749.
Dhillon VS, Dhillon IK. 1998. Chromosome aberrations and sister chromatid exchange studies in patients with prostate cancer: possible evidence of chromosome instability. Cancer Genet Cytogenet 100:143-147.
Dhillon VS, Kler RS, Dhillon IK. 1996. Chromosome instability and sister chromatid exchange (SCE) studies in patients with carcinoma of cervix uteri. Cancer Genet Cytogenet 86:54-57.
Gebhart E, Romahn R, Schneider A, Hoffmann M, Rau D, Tittelbach H. 1993. Cytogenetic studies in lymphocytes of patients with rectal cancer. Environ Health Perspect 101(suppl 3):169-175.
Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen LE, Norppa H, et al. 1998. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res 58:4117-4121.
Hagmar L, Brogger A, Hansteen IL, Heim S, Hogstedt B, Knudsen L, et al. 1994. Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage. Cancer Res 54:2919-2922.
Hagmar L, Strömberg U, Bonassi S, Hansteen I-L, Knudsen LE, Lindholm C, et al. 2004. Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts. Cancer Res 64: 2258-2263.
Liou SH, Lung JC, Chen YH, Yang T, Hsieh LL, Chen CJ, et al. 1999. Increased chromosome-type chromosome aberration frequencies as biomarkers of cancer risk in a blackfoot endemic area. Cancer Res 59:1481-1484.
Mathur R, Chowdhury MR, Singh G. 2000. Recent advances in chromosome breakage syndromes and their diagnosis. Indian Pediatr 37:615-625.
Mitelman F. 2000. Recurrent chromosome aberrations in cancer. Mutat Res 462:247-253.
Natarajan AT. 1993. Mechanisms for induction of mutations and chromosome alterations. Environ Health Perspect 101(suppl 3):225-229.
Nishino K. 1988. Chromosome instability in preleukemic states of adult T-cell leukemia (pre-ATL). Cancer Genet Cytogenet 30:191-200.
Obe G, Pfeiffer P, Savage JR, Johannes C, Goedecke W, Jeppesen P, et al. 2002. Chromosomal aberrations: formation, identification and distribution. Mutat Res 504: 17-36.
Palitti F. 1998. Mechanisms of the origin of chromosomal aberrations. Mutat Res 404:133-137.
Pfeiffer P, Goedecke W, Obe G. 2000. Mechanisms of DNA double-strand repair and their potential to induce chromosomal aberrations. Mutagenesis 15:289-302.
Rossner P, Cerna M, Bavorova H, Pastorkova A, Ocadlikova D. 1995. Monitoring of human exposure to occupational genotoxicants. Cent Eur J Public Health 3: 219-223.
Rossner P, Sram RJ, Bavorova H, Ocadlikova D, Cerna M, Svandova E. 1998. Spontaneous level of chromosomal aberrations in peripheral blood lymphocytes of control individuals of the Czech Republic population. Toxicol Lett 96-97:137-142.
Savage JR. 1998. A brief survey of aberration origin theories. Mutat Res 404:139-147.
Shafei-Benaissa E, Savage JR, Babin P, Larregue M, Papworth D, Tanzer J, et al. 1998. The naevoid basal-cell carcinoma syndrome (Gorlin syndrome) is a chromosomal instability syndrome. Mutat Res 397:287-292.
Smerhovsky Z, Landa K, Rossner P, Brabec M, Zudova Z, Hola N, et al. 2001. Risk of cancer in an occupationally exposed cohort with increased level of chromosomal aberrations. Environ Health Perspect 109: 41-45.
Smerhovsky Z, Landa K, Rossner P, Juzova D, Brabec M, Zudova Z, et al. 2002. Increased risk of cancer in radon-exposed miners with elevated frequency of chromosomal aberrations. Mutat Res 514:165-176.
Sorsa M, Wilbourn J, Vainio H. 1992. Human cytogenetic damage as a predictor of cancer risk. IARC Sci Publ 116:543-554.
Sram RJ. 1981. Cytogenetic analysis of peripheral lymphocytes as a method for monitoring environmental levels of mutagens. In: Industrial and Environmental Xenobiotics: Metabolism and Pharmacokinetics of Organic Chemicals and Methods. (Gut I, Cikrt M, Plaa GL, eds). Berlin: Springer Verlag, 187-193.
Srám RJ, Binkova B. 2000. Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999. Environ Health Perspect 108(suppl 1): 57-70.
Sram RJ, Landa L, Samkova I. 1983. Effect of occupational exposure to epichlorohydrin on the frequency of chromosome aberrations in peripheral lymphocytes. Mutat Res 122: 59-64.
Trivedi AH, Roy SK, Bhachech SH, Patel RK, Dalal AA, Bhatavdekar JM, et al. 1998. Cytogenetic evaluation of 20 sporadic breast cancer patients and their first degree relatives. Breast Cancer Res Treat 48:187-190.
Waters MD, Stack HF, Jackson MA. 1999. Genetic toxicology data in the evaluation of potential human environmental carcinogens. Mutat Res 437:21-49.
WHO. 1975. International Classification of Diseases, 9th Revision. Geneva:World Health Organization.
WHO. 2001. Biomarkers in Risk Assessment: Validity and Validation. Geneva:World Health Organization.
Yunis JJ. 1983. The chromosomal basis of human neoplasia. Science 221:227-236.
Last Updated: March 25, 2005