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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR861 IGR862 IGR859 IGR865 IGR860 atmD,proV,choQ, - SMu1003 yogA, - SMu1005 SMu1006 atmE,pstC,pstA, - SMu1002 vex2, - SMu1001 SMu0998 vex3, - SMu1000 wapE, - SMu0999 atmD,proV,choQ, - SMu1003 yogA, - SMu1005 SMu1006 atmE,pstC,pstA, - SMu1002 vex2, - SMu1001 SMu0998 vex3, - SMu1000 wapE, - SMu0999 atmD,proV,choQ, - SMu1003 yogA, - SMu1005 SMu1006 atmE,pstC,pstA, - SMu1002 SMu1004 SMu1004 vex2, - SMu1001 SMu0998 vex3, - SMu1000 wapE, - SMu0999


LANL Gene ID: SMu1001

GenBank Locus Tag: SMU.1094

DNA Molecule Name:
1  

GenBank ID:
24379530

Gene Name:
vex2  

Definition:
ABC transporter, ATP-binding protein

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
1038011

Gene Stop:
1038667

Gene Length:
657

Molecular Weight*:
24425

pI*:
6.20

Net Charge*:
-2.03

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Comment:
For other components see SMu1000 (MSD1).

For other 'psa' genes see SMu1067 (psaB); SMu1068 (psaA);SMu1069 (psaR); SMu1171 (psaR); SMu1231 (psaA); SMu1752 (psaB) ; SMu1750 (psaR) and SMu1751 (psaA).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ABC transport ATP-binding protein : residues 12-210 are 38% similar to the previously published ABC transport ATP-binding protein, PsaA in S.mutans (gi15625442).

Residues 3-215 are 51% similar to the protein from Lactobacillus sakei (gi15217132).Residues 3-217 are 49% similar to the protein from B.subtilis (gi16077441).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0614 (2e-50).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379530|ref|NP_721485.1|  putative ABC transporter, ATP-...   397   e-109
 gi|125624473|ref|YP_001032956.1|  ABC transporter ATP-bindin...   243   4e-63
 gi|116511695|ref|YP_808911.1|  ABC-type antimicrobial peptid...   242   1e-62
 gi|69245231|ref|ZP_00603309.1|  ABC transporter [Enterococcu...   240   4e-62
 gi|116332978|ref|YP_794505.1|  ABC-type antimicrobial peptid...   230   5e-59
 gi|81429453|ref|YP_396454.1|  Putative ABC transporter, ATP-...   218   3e-55
 gi|28377222|ref|NP_784114.1|  ABC transporter, ATP-binding p...   218   3e-55
 gi|116490519|ref|YP_810063.1|  ABC-type antimicrobial peptid...   217   4e-55
 gi|52078903|ref|YP_077694.1|  ABC transporter [Bacillus lich...   216   8e-55
 gi|116617736|ref|YP_818107.1|  ABC-type antimicrobial peptid...   209   7e-53


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [138-176]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [31-213]T 4.3999900123769397E-48 PF00005 ABC_tran ABC_tran
PS00211 [138-152]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [3-218]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [30-214]T 2.0999999999999103E-14 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [3-212]T 5.000009099153151E-49 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19222 [3-213]T 3.6999781358606606E-72 PTHR19222 PTHR19222 PTHR19222
PTHR19222:SF17 [3-213]T 3.6999781358606606E-72 PTHR19222:SF17 PTHR19222:SF17 PTHR19222:SF17
SSF52540 [3-215]T 1.6E-53 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 15 clades of COG1136
COG name: ABC-type (unclassified) transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1136 is AMt--QVCEBRHUJGPOLinx
Number of proteins in this genome belonging to this COG is 8
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.8e-32.
    IPB001140A    20-66
    IPB001140B    135-173
    IPB001140C    190-218


 ProDom Summary:  Protein Domain Search
Residues 113-205 are 31% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424 which is seen in YN26_MYCTU.

Residues 26-205 are 28% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360 which is seen in O27709_METTH.

Residues 27-214 are 23% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD316735 which is seen in Q9PPY0_UREPA.

Residues 65-135 are 54% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD390374 which is seen in Q9CH67_LACLA.

Residues 74-111 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230 which is seen in P94411_BACSU.

Residues 21-71 are 54% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in P94411_BACSU.

Residues 138-179 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9CH67_LACLA.

Residues 91-203 are 28% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD033004 which is seen in O29198_ARCFU.


Paralogs:  Local Blast Search
SMu1001 is paralogously related (blast p-value < 1e-3) to SMu1751, SMu1068, SMu1246, SMu1231, SMu1288, SMu0786, SMu0916, SMu1920, SMu1762, SMu0218, SMu0884, SMu0731, SMu1380, SMu0517, SMu1003, SMu1210, SMu0849, SMu1949, SMu0594, SMu0971, SMu0418, SMu0235, SMu1950, SMu1023, SMu1079, SMu0390, SMu1811, SMu0805, SMu1428, SMu0258, SMu1518, SMu1710, SMu1037, SMu0907, SMu1036, SMu0234, SMu1064, SMu1757, SMu1517, SMu0944, SMu1316, SMu0475, SMu0374, SMu1724, SMu1959, SMu1649, SMu0823, SMu0596, SMu0024, SMu0950, SMu0825, SMu0752, SMu1545, SMu1410, SMu0987, SMu0216, SMu1065, SMu0986, SMu0476, SMu1306, SMu0976, SMu1093, SMu0335, SMu0837, SMu0824, SMu0224, SMu1202, SMu0164, SMu1050, SMu0836, SMu0666, SMu0729, and SMu1686, all ABC-related ATP-binding proteins.

Pfam Summary:  Pfam Search
Residues 31 to 213 (E-value = 7.7e-47) place SMu1001 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 120 1e-028
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 106 3e-024

Gene Protein Sequence:
MTLKTNNLSYWYNNNPDDYLFKEVNLEFEKGKVYAILGQSGSGKTTFLSL
LAGLDSPKKGKILLNNQNISEKGLTDYRKNAVSTIFQSYNLLPYMTAQQN
VETALDISSVKTTSEKIVTLFDNVGISEDLIDKPVLHLSGGQQQRVAIVR
ALASEHNIIIADEPTGNLDETTTKDIVTIFKKIAHEQKKTVIIVTHEREV
ADSSDIIFELRKKEFTLI

Gene Nucleotide Sequence:  Sequence Viewer
ATGACATTGAAAACAAATAACCTCAGTTACTGGTACAATAACAATCCTGA
TGATTATCTTTTCAAAGAAGTCAATCTTGAATTTGAAAAAGGGAAAGTCT
ATGCTATCCTCGGGCAATCAGGTAGCGGAAAAACTACTTTTCTATCTCTT
CTAGCAGGACTTGACAGTCCTAAAAAAGGAAAAATCCTTCTTAATAATCA
AAATATTAGTGAAAAAGGCTTAACTGATTATCGTAAAAATGCTGTCTCAA
CCATTTTCCAATCCTATAATCTTTTGCCTTATATGACAGCTCAACAAAAT
GTTGAAACCGCACTTGATATTTCATCTGTCAAGACAACAAGTGAAAAAAT
TGTAACATTATTTGATAATGTTGGTATTTCTGAAGATTTGATAGATAAAC
CTGTCTTACATCTCTCCGGAGGTCAGCAACAAAGAGTTGCTATCGTGAGG
GCGCTCGCTAGCGAACACAATATCATTATTGCTGATGAACCAACTGGTAA
TCTAGACGAAACAACAACCAAAGATATTGTTACTATTTTTAAAAAGATTG
CCCATGAGCAGAAGAAAACGGTGATTATTGTTACGCATGAACGAGAAGTT
GCTGATAGTTCTGATATTATTTTCGAATTACGCAAAAAAGAATTTACATT
AATTTAA

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