Basic Search | Intermediate Search | Gene Image Map |  Home

Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap tRNA-Gly-2 tRNA-Gly-1 tRNA-Val-1 tRNA-Thr-1 tRNA-Asp-1 tRNA-Phe-1 tRNA-Ile-1 tRNA-Met-1 tRNA-Met-2 tRNA-Met-3 tRNA-Pro-1 tRNA-Arg-1 tRNA-Lys-1 tRNA-Leu-1 tRNA-Leu-2 tRNA-Ser-2 tRNA-Ser-1 rRNA-5S-1 rRNA-23S-1 IGR17 IGR15 IGR16 IGR13 mreD,rodB, - SMu0017 mreC, - SMu0016 prsA,kprS, - SMu0019 aspC, - SMu0020 gbpB,pcsB,sagA, - SMu0018 mreD,rodB, - SMu0017 mreC, - SMu0016 prsA,kprS, - SMu0019 aspC, - SMu0020 gbpB,pcsB,sagA, - SMu0018 Type: tandem, Name: SMu-TR-1 - 1 Type: tandem, Name: SMu-TR-1 - 1 mreD,rodB, - SMu0017 mreC, - SMu0016 prsA,kprS, - SMu0019 aspC, - SMu0020 gbpB,pcsB,sagA, - SMu0018 recO, - SMu0021 recO, - SMu0021


LANL Gene ID: SMu0016

GenBank Locus Tag: SMU.20

DNA Molecule Name:
1  

GenBank ID:
24378548

Gene Name:
mreC  

Definition:
cell shape-determining protein MreC

Cellular Location:
Membrane, Cytoplasm, Extracellular [Evidence]

Gene Start:
23655

Gene Stop:
24464

Gene Length:
810

Molecular Weight*:
29573

pI*:
9.90

Net Charge*:
4.97

EC:
 

Functional Class:
Cell envelope; Biosynthesis and degradation of murein sacculus and peptidoglycan  

Gene Ontology:
Biological process
  GO:0008360    regulation of cell shape

Cellular component
  GO:0009279    cell outer membrane


Pathway: pathway table

Primary Evidence:
Chia,J.S., Lee,Y.Y., Huang,P.T. and Chen,J.Y.
Identification of Stress-Responsive Genes in Streptococcus mutans
by Differential Display Reverse Transcription-PCR
Infect. Immun. 69 (4), 2493-2501 (2001)
PubMed: 11254612

Chia,J.S., Chang,L.Y., Shun,C.T., Chang,Y.Y. and Chen,J.Y.
A 60-Kilodalton Immunodominant Glycoprotein Is Essential for Cell
Wall Integrity and the Maintenance of Cell Shape in Streptococcus
mutans
Infect. Immun. 69 (11), 6987-6998 (2001)
PubMed: 11598074


Secondary Evidence:
Montagne J.
Genetic and molecular mechanisms of cell size control.
Mol Cell Biol Res Commun. 2000 Oct;4(4):195-202. Review.
PMID: 11409911

Burger A, Sichler K, Kelemen G, Buttner M, Wohlleben W.
Identification and characterization of the mre gene region of Streptomyces coelicolor A3(2).
Mol Gen Genet. 2000 Jul;263(6):1053-60.
PMID: 10954092

Kubo,M., Pierro,D.J., Mochizuki,Y., Kojima,T., Yamazaki,T.,
Satoh,S., Takizawa,N. and Kiyohara,H.
Bacillus stearothermophilus cell shape determinant gene, mreC and
mreD, and their stimulation of protease production in Bacillus
subtilis
Biosci. Biotechnol. Biochem. 60 (2), 271-276 (1996)
PubMed: 9063975


Comment:
For other 'mrc' genes see SMu0017 (mreD) and SMu1045 (mreA).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
This sequence has been previously published in GenBANK as 16753177.

Matches in gapped BLAST to rod-shape determining proteins. Residues 4-269 are 34% similar to the mreC protein of S.pneumoniae (gi15902022). Residues 1-267 are 32% similar to gi15674213 of L.lactis subsp. lactis.





SMu0016 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378548|ref|NP_720503.1|  putative cell shape-determinin...   454   e-126
 gi|16753177|gb|AAL27802.1|  MreC [Streptococcus mutans]           376   e-103
 gi|125716903|ref|YP_001034036.1|  Cell shape determining pro...   157   6e-37
 gi|157075496|gb|ABV10179.1|  cell shape-determining protein ...   156   1e-36
 gi|15902022|ref|NP_346626.1|  rod shape-determining protein ...   155   3e-36
 gi|146317679|ref|YP_001197391.1|  putative cell shape-determ...   149   2e-34
 gi|15674213|ref|NP_268388.1|  cell shape determining protein...   142   3e-32
 gi|116513170|ref|YP_812077.1|  Cell shape-determining protei...   138   3e-31
 gi|69245434|ref|ZP_00603429.1|  Rod shape-determining protei...   138   3e-31
 gi|29377520|ref|NP_816674.1|  rod shape-determining protein ...   137   7e-31


InterPro Summary:  InterProScan

InterPro
IPR001809
Family
Borrelia outer surface lipoprotein
PD001127 [78-219]T 0.0 PD001127 Outrsurface Outrsurface
InterPro
IPR005223
Family
Rod shape-determining protein MreC, subtype
TIGR00219 [1-269]T 3.9173739456927905E-28 TIGR00219 mreC mreC
InterPro
IPR007221
Family
Rod shape-determining protein MreC
PF04085 [114-269]T 2.6999899778780297E-38 PF04085 MreC MreC


COGS Summary:  COGS Search
BeTs to 7 clades of COG1792
COG name: Rod shape-determining protein MreC
Functional Class: M
The phylogenetic pattern of COG1792 is -----q--eb-huj--olinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 121-267 are 36% similar to a (ROD SHAPE-DETERMINING COMPLETE PROTEOME) protein domain (PD011444 which is seen in Q9KI53_ENTFC.

Residues 60-222 are 27% similar to a (PROTEOME COMPLETE MREC SHAPE-DETERMINING) protein domain (PD118507 which is seen in Q9ZCH5_RICPR.


Paralogs:  Local Blast Search
SMu0016 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 114 to 269 (E-value = 2.4e-41) place SMu0016 in the MreC family which is described as rod shape-determining protein MreC (PF04085)

 Structural Feature(s):
Feature Type  Start  Stop
uncleavable  
1  
45
transmembrane  
6  
22

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MRLSRFIVFVITVLLTISIGLFFIFQDSVIIKSVSKPVNLVVSSADEIVH
WPFQVIDNTKHLFKTNSENKTLKRKLEKFEGQKGDLERLKEENTALRKTL
KIKENFPDLTVLSSKVIVRSPVSWLDILTIDLGKNDGVTKNMLVLSNGNL
VGKITQVTATSSSVKLLSNTKSIDEIPVKIATQKGDVFGILTHYDPKTST
FEITQLTSSLDVKKGDSVTTSGLDGQSVEGVSVGKVVSEENNSNNLSRKI
FVKPAVDLSDISHVTLVGD

Gene Nucleotide Sequence:  Sequence Viewer
ATGAGATTGTCACGTTTTATTGTTTTTGTTATCACGGTATTATTAACAAT
TTCAATAGGACTTTTTTTTATTTTCCAAGATTCTGTTATTATAAAATCGG
TATCAAAGCCTGTTAATTTAGTTGTTTCTAGCGCTGATGAGATCGTACAT
TGGCCTTTTCAAGTAATTGATAATACTAAGCATTTGTTTAAAACTAATTC
AGAAAATAAAACATTAAAGCGTAAGTTAGAAAAATTTGAGGGGCAAAAAG
GTGATTTAGAGAGATTAAAAGAAGAAAACACAGCACTTCGTAAGACTTTA
AAAATTAAAGAAAATTTCCCTGATCTAACTGTTTTGTCATCTAAAGTCAT
TGTTCGTTCCCCGGTTTCTTGGTTAGATATATTAACTATAGATTTAGGAA
AAAATGATGGGGTGACAAAAAATATGTTAGTCCTTTCAAATGGTAATTTA
GTGGGGAAAATTACTCAAGTTACTGCTACCTCTAGTTCTGTAAAACTGCT
TTCCAATACTAAAAGCATTGATGAAATTCCAGTCAAAATTGCAACCCAAA
AGGGGGATGTTTTTGGCATTTTAACACATTATGATCCTAAAACCAGTACT
TTTGAAATTACTCAATTAACCTCCTCCTTAGATGTTAAGAAAGGGGATAG
TGTTACAACAAGTGGCTTAGATGGACAAAGTGTTGAAGGTGTGTCTGTTG
GTAAGGTTGTATCTGAAGAAAATAATTCAAACAATCTTTCTCGGAAAATT
TTCGTTAAACCAGCGGTAGATTTATCTGATATCTCCCATGTAACTTTAGT
AGGTGATTAA

Los Alamos National Laboratory • Est 1943

Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy