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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR231 IGR228 IGR229 IGR226 IGR224 IGR232 IGR230 IGR225 IGR233 IGR227 SMu0252 SMu0257 SMu0253 SMu0255 SMu0254 SMu0256 comB, - SMu0259 SMu0261 SMu0260 comA, - SMu0258 SMu0252 SMu0257 SMu0253 SMu0255 SMu0254 SMu0256 comB, - SMu0259 SMu0261 SMu0260 comA, - SMu0258 SMu0252 SMu0254 SMu0256 comB, - SMu0259 SMu0261 SMu0260 comA, - SMu0258 SMu0253 SMu0255 SMu0257


LANL Gene ID: SMu0258

GenBank Locus Tag: SMU.286

DNA Molecule Name:
1  

GenBank ID:
24378790

Gene Name:
comA  

Definition:
competence factor transporting ATP-binding/permease protein

Cellular Location:
Membrane, Cytoplasm, Extracellular [Evidence]

Gene Start:
270628

Gene Stop:
272910

Gene Length:
2283

Molecular Weight*:
85091

pI*:
9.30

Net Charge*:
7.60

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  
Transport and binding proteins; ABC Superfamily: membrane spanning permease  

Gene Ontology:
Biological process
  GO:0006508    proteolysis
  GO:0006810    transport

Cellular component
  GO:0016020    membrane
  GO:0016021    integral to membrane

Molecular function
  GO:0019534    toxin transporter activity
  GO:0017111    nucleoside-triphosphatase activity
  GO:0016887    ATPase activity
  GO:0000166    nucleotide binding
  GO:0008233    peptidase activity
  GO:0005524    ATP binding
  GO:0042626    ATPase activity, coupled to transmembrane movement of substances


Pathway: pathway table

Comment:
For other components see SMu0259 (SBP1).

For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Residues 45-760 are 63% similar in gapped BLAST to gi15902087, a predicted ComA protein from S.pneumoniae.

Residues 267-723 are 24% similar to residues 47-518 of gi5918764, a predicted MutT protein previously published in GenBank. See also gi4103630, gi9802002, gi15625436, gi2062756, gi2492598, gi2952525, gi9802355 and others which don't quite correspond to genomic sequences.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (2e-61).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378790|ref|NP_720745.1|  putative ABC transporter, ATP-...  1448   0.0  
 gi|24380236|ref|NP_722191.1|  putative ABC transporter, ATP-...  1084   0.0  
 gi|148990052|ref|ZP_01821306.1|  Bacteriocin processing pept...  1037   0.0  
 gi|148998208|ref|ZP_01825677.1|  Bacteriocin processing pept...  1036   0.0  
 gi|94993804|ref|YP_601902.1|  Bacteriocin processing peptida...  1024   0.0  
 gi|19745607|ref|NP_606743.1|  putative transport ATP-binding...  1019   0.0  
 gi|55821665|ref|YP_140107.1|  bacteriocin ABC exporter (Pep2...  1008   0.0  
 gi|116628375|ref|YP_820994.1|  ABC-type bacteriocin/lantibio...  1007   0.0  
 gi|55823585|ref|YP_142026.1|  peptide ABC transporter ATP bi...  1004   0.0  
 gi|22087262|gb|AAM90903.1|AF493605_6  SilE [Streptococcus py...   948   0.0


InterPro Summary:  InterProScan

InterPro
IPR001140
Domain
ABC transporter, transmembrane region
PF00664 [206-482]T 2.30000440726539E-58 PF00664 ABC_membrane ABC_membrane
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [666-707]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [554-737]T 6.200014864426819E-53 PF00005 ABC_tran ABC_tran
PS00211 [665-679]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [528-760]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [553-738]T 3.00000000000026E-22 SM00382 AAA AAA
InterPro
IPR005074
Domain
Peptidase C39, bacteriocin processing
PF03412 [53-187]T 9.69997533354385E-61 PF03412 Peptidase_C39 Peptidase_C39
PS50990 [55-182]T 0.0 PS50990 PEPTIDASE_C39 PEPTIDASE_C39
InterPro
IPR005897
Family
Peptidase C39, ABC-type bacteriocin transporter
TIGR01193 [55-760]T 0.0 TIGR01193 bacteriocin_ABC bacteriocin_ABC
InterPro
IPR011527
Domain
ABC transporter, transmembrane region, type 1
PS50929 [215-494]T 0.0 PS50929 ABC_TM1F ABC_TM1F
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [493-759]T 3.4999946686394907E-69 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PIRSF002787 [52-760]T 0.0 PIRSF002787 Hemolysin_sec_B Hemolysin_sec_B
PTHR19242 [161-760]T 0.0 PTHR19242 PTHR19242 PTHR19242
PTHR19242:SF91 [161-760]T 0.0 PTHR19242:SF91 PTHR19242:SF91 PTHR19242:SF91
SSF52540 [528-760]T 3.7E-63 SSF52540 SSF52540 SSF52540
SSF90123 [156-517]T 2.7000000000000003E-69 SSF90123 SSF90123 SSF90123


COGS Summary:  COGS Search
BeTs to 12 clades of COG1132
COG name: ABC-type multidrug/protein/lipid transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inX
Number of proteins in this genome belonging to this COG is 16
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.4e-64.
    IPB001140A    543-589
    IPB001140B    662-700
    IPB001140C    714-743


 ProDom Summary:  Protein Domain Search
Residues 709-741 are 66% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383 which is seen in MESD_LEUME.

Residues 483-679 are 26% similar to a (ABC TRANSPORTER) protein domain (PD241124 which is seen in Q9U0N4_PLAF7.

Residues 595-661 are 70% similar to a (TRANSPORT ATP-BINDING ABC TRANSPORTER) protein domain (PD306522 which is seen in Q9EW69_STRPN.

Residues 188-244 are 59% similar to a (ATP-BINDING TRANSPORT COMPETENCE COMA) protein domain (PD155322 which is seen in COMA_STRPN.

Residues 82-203 are 68% similar to a (TRANSPORT ATP-BINDING COMPLETE PROTEOME) protein domain (PD003456 which is seen in Q9ETN5_STRPN.

Residues 604-661 are 41% similar to a (ATP-BINDING TRANSPORT COMPLETE ABC) protein domain (PD333091 which is seen in Q9ZI23_STRSL.

Residues 665-703 are 64% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459 which is seen in MDR1_LEIEN.

Residues 559-739 are 26% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD316735 which is seen in Q9PPY0_UREPA.

Residues 597-661 are 69% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760 which is seen in Q48553_LEUGE.

Residues 595-663 are 72% similar to a (TRANSPORT ATP-BINDING LACTOCOCCIN) protein domain (PD402967 which is seen in COMA_STRPN.

Residues 351-458 are 74% similar to a (ATP-BINDING TRANSPORT TRANSPORTER) protein domain (PD331886 which is seen in Q9EW68_STRPN.

Residues 220-332 are 60% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348 which is seen in Q48553_LEUGE.

Residues 459-540 are 69% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818 which is seen in Q9EW68_STRPN.

Residues 713-759 are 46% similar to a (ATP-BINDING TRANSPORT MULTIDRUG RESISTANCE-ASSOCIATED) protein domain (PD188719 which is seen in P73400_SYNY3.

Residues 596-661 are 42% similar to a (TRANSPORTER SUBLANCIN ATP-BINDING) protein domain (PD336499 which is seen in Q9XDS0_BBBBB.

Residues 544-592 are 61% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in COMA_STRPN.

Residues 665-707 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9EW69_STRPN.

Residues 518-623 are 29% similar to a (COMPLETE ORF MITOCHONDRION PROTEOME) protein domain (PD000146 which is seen in O77308_PLAFA.

Residues 205-537 are 18% similar to a (TRANSPORT ATP-BINDING 481/LACTOCOCCIN) protein domain (PD102152 which is seen in Q9F445_STRSL.


Paralogs:  Local Blast Search
SMu0258 is paralogously related (blast p-value < 1e-3) to SMu1710, SMu1724, SMu0837, SMu0825, SMu0476, SMu0986, SMu0475, SMu1064, SMu0824, SMu0836, SMu1065, SMu0024, SMu1723, SMu0987, SMu0971, SMu1517, SMu1920, SMu0390, SMu0418, SMu0218, SMu1003, SMu1950, SMu1757, SMu0517, SMu0916, SMu0849, SMu1545, SMu1001, SMu1036, SMu1762, SMu0235, SMu0884, SMu1079, SMu0594, SMu1380, SMu1949, SMu0786, SMu1246, SMu1231, SMu0950, SMu1518, SMu1068, SMu1751, SMu1210, SMu0907, SMu0335, SMu1093, SMu0805, SMu0234, SMu0731, SMu0976, SMu0944, SMu1316, SMu1023, SMu0823, SMu1288, SMu1037, SMu0216, SMu1649, SMu0164, SMu1410, SMu1811, SMu1428, SMu1959, SMu1725, SMu0752, SMu1306, SMu0596, SMu0224, SMu0374, SMu0729, SMu1050, SMu0666, and SMu1686, ATP-binding proteins.


Pfam Summary:  Pfam Search
Residues 53 to 187 (E-value = 8.6e-64) place SMu0258 in the Peptidase_C39 family which is described as Peptidase C39 family (PF03412)
Residues 206 to 482 (E-value = 6.9e-62) place SMu0258 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)
Residues 554 to 737 (E-value = 1.4e-54) place SMu0258 in the ABC_tran family which is described as ABC transporter (PF00005)

 Structural Feature(s):
Feature Type  Start  Stop
uncleavable  
1  
13
transmembrane  
5  
21
transmembrane  
212  
228
transmembrane  
246  
262
transmembrane  
274  
290
transmembrane  
330  
346
transmembrane  
351  
367

Top PDB Hits:
pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 94 7e-020
pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 72 3e-013

Gene Protein Sequence:
MKQVIYVVLIVIAVNILLEIIKRVTKRGGTVSSSNPLPDGQSKLFWRRHY
KLVPQIDTRDCGPAVLASVAKHYGSNYSIAYLRELSKTNKQGTTALGIVE
AAKKLGFETRSIKADMTLFDYNDLTYPFIVHVIKGKRLQHYYVVYGSQNN
QLIIGDPDPSVKVTRMSKERFQSEWTGLAIFLAPQPNYKPHKGEKNGLSN
FFPLIFKQKALMTYIIIASLIVTLIDIVGSYYLQGILDEYIPDQLISTLG
MITIGLIITYIIQQVMAFAKEYLLAVLSLRLVIDVILSYIKHIFTLPMSF
FATRRTGEITSRFTDANQIIDAVASTIFSIFLDMTMVILVGGVLLAQNNN
LFFLTLLSIPIYAIIIFAFLKPFEKMNHEVMESNAVVSSSIIEDINGMET
IKSLTSESARYQNIDSEFVDYLEKNFKLHKYSAIQTALKSGAKLILNVVI
LWYGSRLVMDNKISVGQLITFNALLSYFSNPIENIINLQSKLQSARVANT
RLNEVYLVESEFEKDGDLSENSFLDGDISFENLSYKYGFGRDTLSDINLS
IKKGSKVSLVGASGSGKTTLAKLIVNFYEPNKGIVRINGNDLKVIDKTAL
RRHISYLPQQAYVFSGSIMDNLVLGAKEGTSQEDIIRACEIAEIRSDIEQ
MPQGYQTELSDGAGISGGQKQRIALARALLTQAPVLILDEATSSLDILTE
KKIISNLLQMTEKTIIFVAHRLSISQRTDEVIVMDQGKIVEQGTHKELLA
KQGFYYNLFN

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAACAAGTTATTTATGTTGTTTTAATCGTCATAGCCGTTAACATTCT
CTTAGAGATTATCAAAAGAGTAACAAAAAGGGGAGGGACAGTTTCGTCAT
CTAATCCTTTACCAGATGGGCAGTCTAAGTTGTTTTGGCGCAGACATTAT
AAGCTAGTACCTCAGATTGATACCAGAGACTGTGGGCCGGCAGTGCTGGC
ATCTGTTGCAAAGCATTACGGATCTAATTACTCTATCGCTTATCTGCGGG
AACTCTCAAAGACTAACAAGCAGGGAACAACAGCTCTTGGCATTGTTGAA
GCTGCTAAAAAGTTAGGCTTTGAAACACGCTCTATCAAGGCGGATATGAC
GCTTTTTGATTATAATGATTTGACCTATCCTTTTATCGTCCATGTGATTA
AAGGAAAACGTCTGCAGCATTATTATGTCGTCTATGGCAGCCAGAATAAT
CAGCTGATTATTGGAGATCCTGATCCTTCAGTTAAGGTGACTAGGATGAG
TAAGGAACGCTTTCAATCAGAGTGGACAGGCCTTGCAATTTTCCTAGCTC
CTCAGCCTAACTATAAGCCTCATAAAGGTGAAAAAAATGGTTTGTCTAAT
TTCTTCCCGTTGATCTTTAAGCAGAAAGCTTTGATGACTTATATTATCAT
AGCTAGCTTGATTGTGACGCTCATTGATATTGTCGGATCATACTATCTCC
AAGGAATATTGGACGAGTACATTCCTGATCAGCTGATTTCAACTTTAGGA
ATGATTACGATTGGTCTGATAATAACCTATATTATCCAGCAGGTCATGGC
TTTTGCAAAAGAATACCTCTTGGCCGTACTCAGTTTGCGTTTAGTCATTG
ATGTTATCCTGTCTTATATCAAACATATTTTTACGCTTCCTATGTCTTTC
TTTGCGACAAGGCGAACAGGAGAAATCACGTCTCGTTTTACAGATGCCAA
TCAGATTATTGATGCTGTAGCGTCAACCATCTTTTCAATCTTTTTAGATA
TGACTATGGTAATTTTGGTTGGTGGGGTTTTGTTGGCGCAAAACAATAAC
CTTTTCTTTCTAACCTTGCTCTCCATTCCGATTTATGCCATCATTATTTT
TGCTTTCTTGAAACCCTTTGAGAAAATGAATCACGAAGTGATGGAAAGCA
ATGCTGTGGTAAGTTCTTCTATCATTGAAGATATCAATGGGATGGAAACC
ATTAAATCACTCACAAGTGAGTCCGCTCGTTATCAAAACATTGATAGTGA
ATTTGTTGATTATTTGGAGAAAAACTTTAAGCTACACAAGTATAGTGCCA
TTCAAACCGCATTAAAAAGCGGTGCTAAGCTTATCCTCAATGTTGTCATT
CTCTGGTATGGCTCTCGTCTAGTTATGGATAATAAAATCTCAGTTGGTCA
GCTTATCACCTTTAATGCTTTGCTGTCTTATTTCTCAAATCCAATTGAAA
ATATTATCAATCTGCAATCCAAACTGCAGTCAGCTCGCGTTGCCAATACA
CGTCTTAATGAGGTCTATCTTGTCGAATCTGAATTTGAAAAAGACGGCGA
TTTATCAGAAAATAGCTTTTTAGATGGTGATATTTCGTTTGAAAATCTTT
CTTATAAATATGGATTTGGGCGAGATACCTTATCAGATATTAATTTATCA
ATCAAAAAAGGCTCCAAGGTCAGTCTAGTTGGAGCCAGTGGTTCTGGTAA
AACAACTTTGGCTAAACTGATTGTCAATTTCTACGAGCCTAACAAGGGGA
TTGTTCGAATCAATGGCAATGATTTAAAAGTTATTGATAAGACAGCTTTG
CGGCGGCATATTAGCTATTTGCCGCAACAGGCCTATGTTTTTAGTGGCTC
TATTATGGATAATCTCGTTTTAGGAGCTAAAGAAGGAACGAGTCAGGAAG
ACATTATTCGTGCTTGTGAAATTGCTGAAATCCGCTCGGACATTGAACAA
ATGCCTCAGGGCTATCAGACAGAGTTATCAGATGGTGCCGGTATTTCTGG
CGGTCAAAAACAGCGGATTGCTTTAGCTAGGGCCTTATTAACACAGGCAC
CGGTTTTGATTCTGGATGAAGCCACCAGCAGTCTTGATATTTTGACAGAA
AAGAAAATTATCAGCAATCTCTTACAGATGACGGAGAAAACAATAATTTT
TGTTGCCCACCGCTTAAGCATTTCACAGCGTACTGACGAAGTCATTGTCA
TGGATCAGGGAAAAATTGTTGAACAAGGCACTCATAAGGAACTTTTAGCT
AAGCAAGGTTTCTATTATAACCTGTTTAATTGA

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