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Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. EHP is published by the National Institute of Environmental Health Sciences and its content is free online. Print issues are available by paid subscription.DISCLAIMER
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Environmental Health Perspectives Volume 112, Number 16, November 2004 Open Access
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Systems Biology: The Big Picture Systems Biology: The Big Picture

Angela Spivey

Abstract

Systems biology-a field that draws from mathematics, engineering, nanotechnology, and computer science--is poised to take biology to a new level as it offers understanding of the wealth of data flowing from the “omics” fields. Systems biology looks at the data produced by genomics, proteomics, and metabolomics studies, and visualizes how an organism’s biological processes intertwine to produce a whole greater than the sum of its parts. A working model of an entire biological system could impart enormous power for learning how environmental exposures result in disease. Today, practitioners are working to define their field--for example, its terminology and analytical tools--in an attempt to make their efforts pay off.

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