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Commentary
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| Update on National Toxicology Program (NTP) Assays with Genetically Altered or John R. Bucher National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA Abstract
The NTP is evaluating several lines of genetically altered mice for possible use in identifying and assessing carcinogens. The NIEHS/NTP programs and progress in this area were recently reviewed by the NTP Board of Scientific Counselors (BSC) . A number of comments and concerns were raised. This commentary summarizes and responds to the BSC review and offers some thoughts on future directions for this line of research as well as possible ways genetically altered mice might be integrated into a comprehensive testing strategy. Key words: alternative cancer assays, genetically altered mice, transgenic mice, NTP Board of Scientific Counselors Review. Environ Health Perspect 106:619-621 (1998) . [Online 2 September 1998] http://ehpnet1.niehs.nih.gov/docs/1998/106p619-621bucher/ abstract.html Address correspondence to J.R. Bucher, NIEHS, P.O. Box 12233, MD B3-04, Research Triangle Park, NC 27709. Received 23 June 1998 ; accepted 2 July 1998.
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