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Review
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| Functional Toxicology: A New Approach to Detect Biologically Active Xenobiotics John A. McLachlan National Institute of Environmental Health Sciences, Research Triangle
Park, NC 27709 USA. Abstract
The pervasiveness of chemicals in the enviroment with estrogenic activity and other biological functions recommends the development of new approaches to monitor and study them. Chemicals can be screened for activity in vitro using a panel of human or animal cells that have been transfected with a specific receptor and reporter gene ; for example, the estrogen receptor. By using a variety of different receptors, the screening of xenobiotics for biological functions can be broad. Chemicals could then be classified by their function in vitro which, in some cases, may be a useful guide for toxicological studies. Key words: estrogens, functional toxicology, hormone receptors, xenobiotics. Environ Health Perspect 101:386-387 (1993)
Address corrpespondence to J.A. McLachlan, NIEHS, PO Box 12233, Research Triangle Park, NC 27709 USA. Received 14 July 1993 ; accepted 20 July 1993.
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