References and Notes
1. Costa M. Mechanisms of nickel genotoxicity and carcinogenicity. In: Toxicology of Metals. Boca Raton, FL:CRC Press, 1996;245-251.
2. Kargacin B, Klein CB, Costa M. Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines at the xanthine-guanine phosphoribosyl transferase locus. Mutat Res 300:63-72 (1993).
3. Conway K, Costa M. Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells. Cancer Res 49:6032-6038 (1989).
4. Lee YW, Klein CB, Kargacin B, Salnikow K, Kitahara J, Dowjat K, Zhitkovitch A, Christie NT, Costa M. Carcinogenic nickel silences gene expression by chromatin condensation and DNA hypermethylation: a new model for epigenetic carcinogens. Mol Cell Biol 15(5):2547-2557 (1995).
5. Costa M. Model for the epigenetic mechanisms of action of nongenotoxic carcinogens. Am J Clin Nutr 61(suppl):666S-669S (1995).
6. Klein CB, Conway K, Wang XW, Bhamra RK, Lin XH, Cohen MD, Annab L, Barrett JC, Costa, M. Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control. Science 251:796-799 (1991).
7. Klein CB, Costa M. DNA methylation, heterochromatin and epigenetic carcinogens. Mutat Res 386:163-180 (1997).
8. Broday L, Cai J, Costa M. Nickel enhances telomeric silencing in Saccharomyces cerevisiae. Mutat Res 440(2):121-130 (1999).
9. Salnikow K, Cosentino S, Klein C, Costa M. The loss of thrombospondin transcriptional activity in nickel-transformed cells. Mol Cell Biol 14:851-858 (1994).
10. Salnikow K, Wang S, Costa M. Induction of activating transcription factor 1 by nickel and its role as a negative regulator of thrombospondin I gene expression. Cancer Res 57(22):5060-5066 (1997).
11. Salnikow K, An WG, Melillo G, Blagosklonny MV, Costa M. Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. Carcinogenesis (in press).
Last Updated: August 19, 1999