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| On the Cover | For many Americans today, the fruit of their labors includes a house in the suburbs with all the benefits of living outside urban areas. As some are coming to discover, though, there may be a worm in the apple. Houses in subdivisions built on former orchard lands may be sitting on soil still contaminated with the toxic chemicals used in earlier agricultural pesticides. The Focus (p. A 470) looks at the issue of building on former orchards and the bite it may take out of some American dreams.
image credit: Joseph Tart/EHP, Shutterstock, Library of Congress/Authur Rothstein, Library of Congress Purchase This Issue | |
Perspectives
Director's Perspective
p. A 456
Correspondence
p. A 458
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Environews
Forum
p. A 462
NIEHS News
p. A 466
Focus
p. A 470
Spheres of Influence
p. A 478
Innovations
p. A 482
Science Selections
p. A 486
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Commentaries & Reviews
ENVIRONMENTAL TOXICOLOGY | Evoecotoxicology: Environmental Changes and Life Features Development during the Evolutionary Process—the Record of the Past at Developmental Stages of Living Organisms
Jorge Herkovits
p. 1139 [ Abstract ] [ Full ] [ PDF ]
BIOMONITORS | Biomonitoring and Biomarkers: Exposure Assessment Will Never Be the Same
Dennis Paustenbach and David Galbraith
p. 1143 [ Abstract ] [ Full ] [ PDF ]
HEALTH DISPARITIES | The Environmental "Riskscape" and Social Inequality: Implications for Explaining Maternal and Child Health Disparities
Rachel Morello-Frosch and Edmond D. Shenassa
p. 1150 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Digestion Assays in Allergenicity Assessment of Transgenic Proteins
Rod A. Herman, Nicholas P. Storer, and Yong Gao
p. 1154 [ Abstract ] [ Full ] [ PDF ]
Research
EXPOSURE ASSESSMENT | Oxidative Metabolites of Diisononyl Phthalate as Biomarkers for Human Exposure Assessment
Manori J. Silva, John A. Reidy, James L. Preau Jr., Larry L. Needham, and Antonia M. Calafat
p. 1158 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Estimation of Relative Bioavailability of Lead in Soil and Soil-Like Materials Using Young Swine
Stan W. Casteel, Christopher P. Weis, Gerry M. Henningsen, and William J. Brattin
p. 1162 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System
Alison Elder, Robert Gelein, Vanessa Silva, Tessa Feikert, Lisa Opanashuk, Janet Carter, Russell Potter, Andrew Maynard, Yasuo Ito, Jacob Finkelstein, and Günter Oberdörster
 Also see Science Selections, p. A486
p. 1172 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Levels and Concentration Ratios of Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers in Serum and Breast Milk in Japanese Mothers
Kayoko Inoue, Kouji Harada, Katsunobu Takenaka, Shigeki Uehara, Makoto Kono, Takashi Shimizu, Takumi Takasuga, Kurunthachalam Senthilkumar, Fumiyoshi Yamashita, and Akio Koizumi
p. 1179 [ Abstract ] [ Full ] [ PDF ]
HUMAN TOXICOLOGY | Low Blood Lead Levels Do Not Appear to Be Further Reduced by Dietary Supplements
Brian L. Gulson, Karen J. Mizon, Michael J. Korsch, and Alan J. Taylor
p. 1186 [ Abstract ] [ Full ] [ PDF ]
DNA REPAIR | Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic
Angeline S. Andrew, Jefferey L. Burgess, Maria M. Meza, Eugene Demidenko, Mary G. Waugh, Joshua W. Hamilton, and Margaret R. Karagas
p. 1193 [ Abstract ] [ Full ] [ PDF ]
INFECTIOUS DISEASE | Inferences Drawn from a Risk Assessment Compared Directly with a Randomized Trial of a Home Drinking Water Intervention
Joseph N.S. Eisenberg, Alan Hubbard, Timothy J. Wade, Matthew D. Sylvester, Mark W. LeChevallier, Deborah A. Levy, and John M. Colford Jr.
p. 1199 [ Abstract ] [ Full ] [ PDF ]
PROSTATE CANCER | Phorate Exposure and Incidence of Cancer in the Agricultural Health Study
Rajeev Mahajan, Matthew R. Bonner, Jane A. Hoppin, and Michael C.R. Alavanja
p. 1205 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Volatile Organic Compounds and Pulmonary Function in the Third National Health and Nutrition Examination Survey, 1988–1994
Leslie Elliott, Matthew P. Longnecker, Grace E. Kissling, and Stephanie J. London
p. 1210 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Coarse Particles and Heart Rate Variability among Older Adults with Coronary Artery Disease in the Coachella Valley, California
Michael J. Lipsett, Feng C. Tsai, Linda Roger, Mary Woo, and Bart D. Ostro
p. 1215 [ Abstract ] [ Full ] [ PDF ]
BIOMARKERS | Mycotoxin Adducts on Human Serum Albumin: Biomarkers of Exposure to Stachybotrys chartarum
Iwona Yike, Anne M. Distler, Assem G. Ziady, and Dorr G. Dearborn
p. 1221 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Ozone and Daily Mortality in Shanghai, China
Yunhui Zhang, Wei Huang, Stephanie J. London, Guixiang Song, Guohai Chen, Lili Jiang, Naiqing Zhao, Bingheng Chen, and Haidong Kan
p. 1227 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Lead Exposure Is Associated with Decreased Serum Paraoxonase 1 (PON1) Activity and Genotypes
Wan-Fen Li, Mei-Hung Pan, Meng-Chu Chung, Chi-Kung Ho, and Hung-Yi Chuang
p. 1233 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Application of Cryopreserved Human Hepatocytes in Trichloroethylene Risk Assessment: Relative Disposition of Chloral Hydrate to Trichloroacetate and Trichloroethanol
Apryl Bronley-DeLancey, David C. McMillan, JoEllyn M. McMillan, David J. Jollow, Lawrence C. Mohr, and David G. Hoel
p. 1237 [ Abstract ] [ Full ] [ PDF ]
AUTOIMMUNE DISEASE | Nested Case–Control Study of Autoimmune Disease in an Asbestos-Exposed Populationt
Curtis W. Noonan, Jean C. Pfau, Theodore C. Larson, and Michael R. Spence
p. 1243 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Cancer Incidence among Pesticide Applicators Exposed to Cyanazine in the Agricultural Health Study
Shannon M. Lynch, Jennifer A. Rusiecki, Aaron Blair, Mustafa Dosemeci, Jay Lubin, Dale Sandler, Jane A. Hoppin, Charles F. Lynch, and Michael C.R. Alavanja
p. 1248 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | Cooperation of the Inducible Nitric Oxide Synthase and Cytochrome P450 1A1 in Mediating Lung Inflammation and Mutagenicity Induced by Diesel Exhaust Particles
Hong-Wen Zhao, Mark W. Barger, Joseph K.H. Ma, Vincent Castranova, and Jane Y.C. Ma
p. 1253 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | The OECD Program to Validate the Rat Hershberger Bioassay to Screen Compounds for in Vivo Androgen and Antiandrogen Responses. Phase 1: Use of a Potent Agonist and a Potent Antagonist to Test the Standardized Protocol
William Owens, Errol Zeiger, Michael Walker, John Ashby, Lesley Onyon, and L. Earl Gray Jr.
p. 1259 [ Abstract ] [ Full ] [ PDF ]
SKIN | Di-(2-ethylhexyl) Phthalate Enhances Atopic Dermatitis-Like Skin Lesions in Mice
Hirohisa Takano, Rie Yanagisawa, Ken-ichiro Inoue, Takamichi Ichinose, Kaori Sadakane, and Toshikazu Yoshikawa
p. 1266 [ Abstract ] [ Full ] [ PDF ]
NEUROBEHAVIORAL DISEASE | UMTS Base Station-like Exposure, Well-Being, and Cognitive Performance
Sabine J. Regel, Sonja Negovetic, Martin Röösli, Veronica Berdiñas, Jürgen Schuderer, Anke Huss, Urs Lott, Niels Kuster, and Peter Achermann
p. 1270 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | Endocrine Disrupting Chemicals Research Program of the U.S. Environmental Protection Agency: Summary of a Peer-Review Report
Anna K. Harding, George P. Daston, Glen R. Boyd, George W. Lucier, Stephen H. Safe, Juarine Stewart, Donald E. Tillitt, and Glen Van Der Kraak
p. 1276 [ Abstract ] [ Full ] [ PDF ]
Environmental Medicine
NEURODEGENERATIVE DISEASE | Hearing Loss in Workers Exposed to Toluene and Noise
Shu-Ju Chang, Chiou-Jong Chen, Chih-Hui Lien, and Fung-Chang Sung
Also see Science Selections, p. A487
p. 1283 [ Abstract ] [ Full ] [ PDF ]
Children's Health
NEURODEVELOPMENT | Effect of Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons on Neurodevelopment in the First 3 Years of Life among Inner-City Children
Frederica P. Perera, Virginia Rauh, Robin M. Whyatt, Wei-Yann Tsai, Deliang Tang, Diurka Diaz, Lori Hoepner, Dana Barr, Yi-Hsuan Tu, David Camann, and Patrick Kinney
Also see Science Selections, p. A487
p. 1287 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Increased Mortality from Lung Cancer and Bronchiectasis in Young Adults after Exposure to Arsenic in Utero and in Early Childhood
Allan H. Smith, Guillermo Marshall, Yan Yuan, Catterina Ferreccio, Jane Liaw, Ondine von Ehrenstein, Craig Steinmaus, Michael N. Bates, and Steve Selvin
Also see Science Selections, p. A486
p. 1293 [ Abstract ] [ Full ] [ PDF ]
FETAL DEVELOPMENT | PAH–DNA Adducts in Cord Blood and Fetal and Child Development in a Chinese Cohort
Deliang Tang, Tin-yu Li, Jason J. Liu, Yu-hui Chen, Lirong Qu, and Frederica Perera
p. 1297 [ Abstract ] [ Full ] [ PDF ]
INFECTIOUS DISEASE | Effect of Prenatal Exposure to Polychlorinated Biphenyls on Incidence of Acute Respiratory Infections in Preschool Inuit Children
Frédéric Dallaire, Éric Dewailly, Carole Vézina, Gina Muckle, Jean-Philippe Weber, Suzanne Bruneau, and Pierre Ayotte
p. 1301 [ Abstract ] [ Full ] [ PDF ]
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