Appendix
A - Background and History of Use
Lewis,
Y. S. and S. Neelakantan. Research Paper (-)-Hydroxycitric Acid
- The Principal Acid in the Fruits of Garcinia Cambogia Desr.
Central Food Technological Resarch Institute, Mysore, India
Received 15 March 1964. Available online 2 April 2001.
Clouatre, Dallas PhD. The Diet and Health Benefits of HCA.
Published
Material
Appendix
B - Safety
Soni, M. G., et al. Safety assessment of (-)-hydroxycitric
acid and Super CitriMax, a novel calcium/potassium salt. Food
and Chemical Toxicology 42 (2004) 1513-1529. Published
Material
Ohia,
S. E., et al. Safety and mechanism of appetite suppression by
a novel Hydroxycitric Acid extract (HCA-SX). Department of Pharmacy
Sciences, Creighton University School of Pharmacy and Allied
health Professions, Omaha, NE, USA.
Shara,
M., et al. Physico-chemical properties of a novel (-)-hydroxycitric
acid extract and its effect on body weight, selected organ weights,
hepatic lipid peroxidation and DNA fragmentation, hematology
and clinical chemistry, and histopathological changes over a
period of 90 days. Department of Pharmacy Sciences, School of
Pharmacy and Health Professions, Creighton University Medical
Center, Omaha, NE; IDEXX Veterinary Services, Inc., West Sacramento,
CA, USA.
Shara, M., et al. Dose- and time- dependent effects of a novel
(-)-hydroxycitric acid extract on body weight, hepatic and testicular
lipid peroxidation, DNA fragmentation and histopathological
data over a period of 90 days. Molecular and Cellular Biochemistry
254: 339-346, 2003. Published
Material
Appendix
C - Mechanisms of Action
Lowenstein,
J. M. Experiments with (-)-Hydroxycitrate. Graduate Department
of Biochemistry, Brandeis University, Waltham, MA.
Watson,
J. A., M. Fang, and J. M. Lowenstein. Tricarballylate and Hydroxycitrate:
Substrate and Inhibitor of ATP: Citrate Oxaloacetate Lyase.
Graduate Department of Biochemistry, Brandeis University, Waltham,
MA.
Pruess,
H. G. Effects of a natural extract of (-)-hydroxycitric acid
(HCA-SX) and a combination of HCA-SX plus niacin-bound chromium
and Gymnema sylvestre extract on weight loss.
