Press Center
1998 Nominations - Report on Carcinogens
[Federal Register February 3, 1998 (Volume 63, Number 22)]
[Notices]
[Page 5565 - 5567]
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program; Call for Public Comments; Substances, Mixtures and Exposure Circumstances Proposed for Listing in or Delisting (Removing) From the Report on Carcinogens, Ninth Edition
Background
The National Toxicology Program (NTP) announces its intent
to review additional substances, mixtures and exposure circumstances
for possible listing in or delisting (removing) from the Report
on Carcinogens, Ninth Edition. This Report (previously known as
the Annual Report on Carcinogens) is a Congressionally-mandated
listing of known human carcinogens and reasonably anticipated
human carcinogens and its preparation is delegated to the National
Toxicology Program by the Secretary, Department of Health and
Human Services (DHHS). Section 301(b)(4) of the Public Health
Service Act, as amended, provides that the Secretary, (DHHS),
shall publish a report which contains a list of all substances
(1) which either are known to be human carcinogen or may
reasonably anticipated to be a human carcinogen, and (2)
to which a significant number of persons residing in the United
States (US) are exposed. The law also states that the reports
should provide available information on the nature of exposures,
the estimated number of persons exposed and the extent to which
the implementation of Federal regulations decreases the risk to
public health from exposure to these chemicals.
The review of the substances, mixtures or exposure circumstances for listing in, changing the current listing from reasonably anticipated to be a human carcinogen to known to be a human carcinogen or delisting from the Ninth Report will involve a multiphased, peer review process involving two Federal scientific review groups and one non-government, scientific peer review body (a subcommittee of the NTP Board of Scientific Counselors) which will meet in an open, public meeting that will provide for public comments. All available data relevant to the criteria for inclusion or removal of candidate agents, substances, mixtures or exposure circumstances in the Report will be evaluated by the three scientific review committees. The criteria to be used in the review process and the detailed description of the review procedures, including the steps in the formal review process, can be obtained by contacting: Dr. C. W. Jameson, National Toxicology Program, Report on Carcinogens, MD EC-14, P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541-4096, fax: (919) 541-2242, email: jameson@niehs.nih.gov.
Public Comment Requested
The NTP will be considering 11 substances, mixtures and exposure
circumstances in 1998, for either listing in or delisting (removing)
from, or changing the current listing from reasonably anticipated
to be a human carcinogen to the known to be a human carcinogen
category in the Ninth Report. These substances, mixtures or exposure
circumstances are provided in the following table with their Chemical
Abstracts Services (CAS) Registry numbers (where available) and
pending review action. The NTP solicits public input on these
11 substances, mixtures and exposure circumstances and asks for
relevant information anyone may have on carcinogenesis from completed,
ongoing, or planned studies by others, as well as current production
data, use patterns, and human exposure information for any of
the substances, mixtures or exposure circumstances listed in this
announcement. Comments concerning the review of these substances,
mixtures or exposure circumstances for listing in or delisting
from the Ninth Report on Carcinogens will be accepted for a period
of 45 days from the date of the publication of this announcement
in the Federal Register. Comments or questions should be directed to
Dr. C. W. Jameson at the address listed above.
Public Nominations for Delisting or Listing Encouraged
The NTP solicits and encourages the broadest participation
from interested individuals or parties in nominating agents, substances,
or mixtures for listing in or delisting from the Ninth and future
Reports on Carcinogens. Petitions should contain a rationale for
listing or delisting. Appropriate background information and relevant
data (e.g. Journal articles, NTP Technical Reports, IARC listings,
exposure surveys, release inventories, etc.) which support a petition
should be provided or referenced when possible.
A detailed description of listing/delisting procedures, including the steps in the formal review process, can be obtained by contacting Dr. Jameson at the address listed above.
Dated: 1/26/98
__________________________
Kenneth Olden, Ph.D.
Director,
National Toxicology Program
[Billing Code 4140-01-P]
Agents, Substances, Mixtures or Exposure Circumstances
to be Reviewed in 1998, for Consideration of Listing in or Delisting from
the Ninth Report on Carcinogens
SUBSTANCE OR EXPOSURE CIRCUMSTANCE/ CAS NUMBER | PRIMARY USES OR EXPOSURES | TO BE REVIEWED FOR |
Alcoholic Beverages | Consumption of alcoholic beverages | Listing in the 9th Report |
Boot and Shoe Manufacture and Repair | Workers in the boot and shoe manufacture and repair industry | Listing in the 9th Report |
Diesel Particulates | Diesel engine exhaust | Listing in the 9th Report |
Environmental Tobacco Smoke | "Passive" inhalation of tobacco smoke from environmental sources | Listing in the 9th Report |
Ethyl Acrylate/ 140-88-5 | Monomer used to produce polymers and copolymers for use in latex paints, textiles, etc. | Delisting from the Report on Carcinogens |
Ethylene Oxide/ 75-21-8 | Industrial chemical used as an intermediate in the manufacture of other chemicals; e.g., ethylene glycol and is widely used in the health care industry as a sterilant. | Change current listing to the Known to be a Human Carcinogen category |
Isoprene/ 78-79-5 | The monomeric unit of natural rubber and naturally occurring terpenes and steroids and widely used in the production of isoprene-butadiene copolymers. |
Listing in the 9th Report |
Methyl-t-Butyl Ether/ 1634-04-4 | Used as an additive in unleaded gasoline in amounts up to 11%. | Listing in the 9th Report |
Nickel and Nickel Compounds / 7440-02-0 | Many industrial and commercial applications. | Change current listing to the Known to be a Human Carcinogen category |
Nickel Refining | Workers in the nickel refining industry | Listing in the 9th Report |
Silica, Crystalline/ 7631-86-9 | Exposure from mining and quarrying of coal and other minerals, stone cutting, production of glass and ceramics and in occupations such as sandblasting, polishing and grinding. | Change current listing to the Known to be a Human Carcinogen category |
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