Chairs/Organizers Saul Genuth Case Western Reserve University Gerald W. Hart Johns Hopkins University Salvatore Sechi National Institute of Diabetes and Digestive and Kidney Diseases	Purpose: High-throughput DNA sequencing has changed biomedical research. It is, however, apparent that knowledge of the genome alone is not sufficient for a complete understanding of complex diseases. This is partially due to complex environmental factors that together with the genotype determine a specific phenotype. A phenotype at the molecular level can be partially characterized for its proteins, macromolecular complexes, and their regulation that often occurs at the post-translational level. The application of high-throughput protein characterization methodologies to human specimens is usually considered part of clinical proteomics. The main topic of this workshop is the application of proteomic technologies to clinical studies relevant to diabetes and its complications. Particular emphasis will be on projects aimed at the identification of novel protein markers of diabetes and pre-diabetes, but more generally the application of proteomics to clinical studies will be discussed through various presentations and discussion sessions. This workshop also will provide a venue to bring together investigators with expertise in proteomics and clinical investigators interested in applying this technology to problems related to diabetes and its complications. Sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases