Kidney Disease Clinical Studies Initiative (KDCSI) : NIDDK

Kidney Disease Clinical Studies Initiative (KDCSI)

  • Funding Mechanisms
  • Meeting Reports
  • Clinical Trials Inventory
  • The Kidney Disease Clinical Studies Initiative (KDCSI) is a new paradigm for kidney disease clinical research. The KDCSI aims to improve the quality and quantity of clinical studies by maximizing outcomes and reducing costs through sharing of resources obtained in previous studies, such as samples, specimens, and data, and through innovative funding mechanisms.

    The main goals of the KDCSI are two-fold:

    • Encourage the full and effective use of resources, including data and biological samples, from NIDDK-supported clinical trials and epidemiological studies in kidney disease (Clinical Trials Inventory)

    • Increase the number of investigator-initiated clinical studies, including small-scale, interventional studies; observational studies; and feasibility studies that could lead to potential, large-scale interventional trials that are adequately powered and efficient (Funding Mechanisms)

    The Kidney Disease Clinical Studies Initiative is an outgrowth of a task force meeting convened in March 2002 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Council of American Kidney Societies (CAKS). The workshop's aims were to develop ways to improve clinical trials, increase their number, and cut research costs. (Task Force Report)

    The first semi-annual meeting of the KDCSI convened in February 2003, bringing together numerous investigators currently funded by the consortium as well as other interested researchers. The workshop began with a complete inventory of past, present, and future NIDDK clinical studies and short presentations by investigators involved in those studies. Present and future repositories and their policies for accessing data and samples were discussed, and subject-area work groups met to develop research priorities in their areas: chronic kidney disease/progression, end-stage renal disease, pediatric kidney disease, and acute renal failure. At that meeting, KUH/NIDDK program staff (pdf) presented new funding mechanisms for concept development and ancillary studies.


    Funding Mechanisms

    Concept development supplements will provide planning assistance for the development of grant proposals for kidney disease research.

    In addition, program announcements have been issued by NIDDK for the following:
    • Ancillary Studies of Kidney Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases (PA-03-091)
    • Research Grants for Clinical Studies of Kidney Disease (PAR-03-105)
    • Notice of correction (NOT-DK-03-005 ) to the above PA, Research Grants for Clinical Studies of Kidney Disease


    Meeting Reports

    Task Force Workshop March 7-8, 2002 First Semi-Annual KDCSI Meeting, February 4-5, 2003

    Kidney Disease Clinical Studies Inventory (KUH/NIDDK)

    Table of Contents

    Pediatrics Completed Trials Ongoing Trials Trials to be Implemented

    Chronic Kidney Disease/Progression

    Completed Trials Ongoing Trials Trials to be Implemented

    End Stage Renal Disease

    Completed Trials Ongoing Trials Trials to be Implemented

    Acute Renal Failure

    Ongoing Trials Trials to be Implemented

    Page last updated: November 25, 2008

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