| | This journal provides immediate access to some articles. Research Articles Introduction. Bioinformatics: from molecules to systems David T Jones, Michael J. E Sternberg, and Janet M Thornton Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 389–391. Published online 2005 February 1. doi: 10.1098/rstb.2005.1811.PMCID: PMC1609343 Finding the molecular basis of complex genetic variation in humans and mice Richard Mott Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 393–401. Published online 2006 February 1. doi: 10.1098/rstb.2005.1798.PMCID: PMC1609339 Comparative genomics and genome evolution in yeasts Kenneth H Wolfe Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 403–412. Published online 2006 February 1. doi: 10.1098/rstb.2005.1799.PMCID: PMC1609344 Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery Tom L Blundell, Bancinyane L Sibanda, Rinaldo Wander Montalvão, Suzanne Brewerton, Vijayalakshmi Chelliah, Catherine L Worth, Nicholas J Harmer, Owen Davies, and David Burke Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 413–423. Published online 2006 February 3. doi: 10.1098/rstb.2005.1800.PMCID: PMC1609333 Exploiting protein structure data to explore the evolution of protein function and biological complexity Russell L Marsden, Juan A.G Ranea, Antonio Sillero, Oliver Redfern, Corin Yeats, Michael Maibaum, David Lee, Sarah Addou, Gabrielle A Reeves, Timothy J Dallman, and Christine A Orengo Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 425–440. Published online 2006 February 1. doi: 10.1098/rstb.2005.1801.PMCID: PMC1609337 The proteome: structure, function and evolution Keiran Fleming, Lawrence A Kelley, Suhail A Islam, Robert M MacCallum, Arne Muller, Florencio Pazos, and Michael J.E Sternberg Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 441–451. Published online 2006 February 3. doi: 10.1098/rstb.2005.1802.PMCID: PMC1609342 Rigorous performance evaluation in protein structure modelling and implications for computational biology John Moult Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 453–458. Published online 2006 February 1. doi: 10.1098/rstb.2005.1810.PMCID: PMC1609338 Prediction and design of macromolecular structures and interactions David Baker Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 459–463. Published online 2006 February 3. doi: 10.1098/rstb.2005.1803.PMCID: PMC1609347 Towards genome-scale structure prediction for transmembrane proteins Naama Hurwitz, Marialuisa Pellegrini-Calace, and David T Jones Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 465–475. Published online 2006 February 3. doi: 10.1098/rstb.2005.1804.PMCID: PMC1609336 From genomes to systems: the path with yeast Stephen G Oliver Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 477–482. Published online 2006 February 1. doi: 10.1098/rstb.2005.1805.PMCID: PMC1609341 Modelling in molecular biology: describing transcription regulatory networks at different scales Thomas Schlitt and Alvis Brazma Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 483–494. Published online 2006 February 1. doi: 10.1098/rstb.2005.1806.PMCID: PMC1609346 Transcriptional noise and cellular heterogeneity in mammalian macrophages S Ramsey, A Ozinsky, A Clark, K.D Smith, P de Atauri, V Thorsson, D Orrell, and H Bolouri Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 495–506. Published online 2006 February 1. doi: 10.1098/rstb.2005.1808.PMCID: PMC1609340 The origins and evolution of functional modules: lessons from protein complexes Jose B Pereira-Leal, Emmanuel D Levy, and Sarah A Teichmann Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 507–517. Published online 2006 February 3. doi: 10.1098/rstb.2005.1807.PMCID: PMC1609335 Comparative analysis of environmental sequences: potential and challenges Konrad U Foerstner, Christian von Mering, and Peer Bork Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 519–523. Published online 2006 February 1. doi: 10.1098/rstb.2005.1809.PMCID: PMC1609345 Bioinformatic challenges for the next decade(s) David Eisenberg, Edward Marcotte, Andrew D McLachlan, and Matteo Pellegrini Philos Trans R Soc Lond B Biol Sci. 2006 March 29; 361(1467): 525–527. Published online 2006 February 3. doi: 10.1098/rstb.2005.1797.PMCID: PMC1609334 |