The Genomic Resource & Technology Development Program will support projects that take advantage of recent development in genetic analysis, genomic-based technologies and systems biology to propose innovative ways of understanding the biological networks behind diseases of interest to NIDDK, such as metabolic disease. Emphasis will be put on pulling together a community of researchers to propose integrated approaches and develop new tools to solve complex problems that are difficult to tackle in a traditional laboratory setting and require multi-disciplinary teams. Areas of interest include:
- genome-wide analysis of transcriptional regulatory networks in health and disease, tissue development & regeneration, etc…
- functional genomics in disease-relevant organs under normal and pathological conditions
- forward and reverse chemical genetic to explore regulatory networks involved in disease biology
- development of high-throughput, cell-based screening platforms to interrogate basic and disease biology
- development of partnerships and integrated research projects between physicians, geneticists, computational scientists, biochemists and others, to better identify the underlying causes of complex diseases.
For more information, contact Dr. Olivier C. Blondel, Director, Endocrine Systems Biology Program.