This program supports both basic and clinical research investigating the neural and endocrine mechanisms contributing to obesity and the pathophysiological consequences of obesity, particularly Type II diabetes. Also included are studies which explore the neuronal and peptidergic pathways regulating food intake and other behaviors influencing body adiposity. Thus, proposals encompassed by this program will take an integrative approach to the goal of elucidating the physiological and behavioral factors contributing to the etiology of obesity. Clinical studies which expand on basic research findings and/or explore basic mechanisms involved in human obesity are encouraged. Examples of areas of interest include:
- Neurobiology of human obesity and behavior
- Neuropeptides and their receptors involved in the regulatory pathways controlling feeding behavior, satiety and energy expenditure
- Intrauterine and neonatal environment in the development of obesity
- Imaging of neural pathways involved in the regulation of food intake
For more information, contact Dr. Arthur Castle, Director, Metabolomics and Informatics Programs.