Cincinnati Children's Hospital Medical Center : NIDDK

Cincinnati Children's Hospital Medical Center

Cincinnati DDRDC: Center for Growth and Development (CGD)

Director: Mitchell B. Cohen, M.D.
Co-Directors: Bruce Aronow, Ph.D., Jorge A. Bezerra, M.D., S. Steven Potter, Ph.D., David P. Witte, M.D

Center Focus

The overall goal of the Cincinnati DDRDC: Center for Growth and Development (CGD) is to promote research that will yield insights into the fundamental processes of growth and development in the digestive tract and lead to novel or improved therapies. The specific goals of the CGD derive from the central theme that understanding the molecular mechanisms that control development of the gastrointestinal tract and liver will result in strategies to correct intestinal, nutritional and liver disease. Furthermore, continued interdisciplinary collaboration enhanced by the DDRDC and our strong research environment, continue to lead to productive investigation in digestive diseases. The 28 full members and six associate members come from nine different divisions within the Department of Pediatrics and a total of six Departments within the University of Cincinnati College of Medicine. These investigators are grouped into four working areas that all impact growth and development: Differentiation, Absorption and Secretion, Inflammation, and Regeneration and repair; 2) To promote interactions among scientists with diverse backgrounds, 3) To attract basic investigators to the study of gastrointestinal and liver growth and development, and 4) To foster translational research in digestive disease. The specific aims of the Center are achieved primarily through three inner-related Biomedical Research Cores, which provide high quality state of the art experiments to identify novel genes expressed in the digestive organs of humans and in animal models of disease; design assistance and statistical and computational analysis for the complex microarray experiments; and consultation and technical support for morphology studies, including in situ hybridization to localize gene expression identified by microarray analysis. Thus, at many levels, there is strong synergy among the research base and among the Biomedical Research Cores. This synergy increases efficiency, promotes new research directions, and fosters collaborations.


Core Facilities

  • Microarray
  • Bioinformatics
  • Integrative Morphology

Page last updated: November 25, 2008

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