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Volume 4(11);  November 2008
Education
Analyzing ChIP-chip Data Using Bioconductor
Joern Toedling and Wolfgang Huber
PLoS Comput Biol. 2008 November; 4(11): e1000227. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000227.
PMCID: PMC2582686
Review
Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities
Marcel E. Dinger, Ken C. Pang, Tim R. Mercer, and John S. Mattick
PLoS Comput Biol. 2008 November; 4(11): e1000176. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000176.
PMCID: PMC2518207
Research Articles
Facilitated Variation: How Evolution Learns from Past Environments To Generalize to New Environments
Merav Parter, Nadav Kashtan, and Uri Alon
PLoS Comput Biol. 2008 November; 4(11): e1000206. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000206.
PMCID: PMC2563028
A Hierarchy of Time-Scales and the Brain
Stefan J. Kiebel, Jean Daunizeau, and Karl J. Friston
PLoS Comput Biol. 2008 November; 4(11): e1000209. Published online 2008 November 14. doi: 10.1371/journal.pcbi.1000209.
PMCID: PMC2568860
Hierarchical Models in the Brain
Karl Friston
PLoS Comput Biol. 2008 November; 4(11): e1000211. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000211.
PMCID: PMC2570625
A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges
Murad Banaji, Alfred Mallet, Clare E. Elwell, Peter Nicholls, and Chris E. Cooper
PLoS Comput Biol. 2008 November; 4(11): e1000212. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000212.
PMCID: PMC2573000
Transmembrane Topology and Signal Peptide Prediction Using Dynamic Bayesian Networks
Sheila M. Reynolds, Lukas Käll, Michael E. Riffle, Jeff A. Bilmes, and William Stafford Noble
PLoS Comput Biol. 2008 November; 4(11): e1000213. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000213.
PMCID: PMC2570248
Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes
Osnat Penn, Adi Stern, Nimrod D. Rubinstein, Julien Dutheil, Eran Bacharach, Nicolas Galtier, and Tal Pupko
PLoS Comput Biol. 2008 November; 4(11): e1000214. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000214.
PMCID: PMC2566816
Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals
Yair Field, Noam Kaplan, Yvonne Fondufe-Mittendorf, Irene K. Moore, Eilon Sharon, Yaniv Lubling, Jonathan Widom, and Eran Segal
PLoS Comput Biol. 2008 November; 4(11): e1000216. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000216.
PMCID: PMC2570626
Inferring Pathway Activity toward Precise Disease Classification
Eunjung Lee, Han-Yu Chuang, Jong-Won Kim, Trey Ideker, and Doheon Lee
PLoS Comput Biol. 2008 November; 4(11): e1000217. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000217.
PMCID: PMC2563693
Genome-Wide Analysis of Human Disease Alleles Reveals That Their Locations Are Correlated in Paralogous Proteins
Mark Yandell, Barry Moore, Fidel Salas, Chris Mungall, Andrew MacBride, Charles White, and Martin G. Reese
PLoS Comput Biol. 2008 November; 4(11): e1000218. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000218.
PMCID: PMC2565504
A Low Dimensional Description of Globally Coupled Heterogeneous Neural Networks of Excitatory and Inhibitory Neurons
Roxana A. Stefanescu and Viktor K. Jirsa
PLoS Comput Biol. 2008 November; 4(11): e1000219. Published online 2008 November 14. doi: 10.1371/journal.pcbi.1000219.
PMCID: PMC2574034
Emergence of Functional Hierarchy in a Multiple Timescale Neural Network Model: A Humanoid Robot Experiment
Yuichi Yamashita and Jun Tani
PLoS Comput Biol. 2008 November; 4(11): e1000220. Published online 2008 November 7. doi: 10.1371/journal.pcbi.1000220.
PMCID: PMC2570613
Polar or Apolar—The Role of Polarity for Urea-Induced Protein Denaturation
Martin C. Stumpe and Helmut Grubmüller
PLoS Comput Biol. 2008 November; 4(11): e1000221. Published online 2008 November 14. doi: 10.1371/journal.pcbi.1000221.
PMCID: PMC2570617
A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates
Stefan Auer, Filip Meersman, Christopher M. Dobson, and Michele Vendruscolo
PLoS Comput Biol. 2008 November; 4(11): e1000222. Published online 2008 November 14. doi: 10.1371/journal.pcbi.1000222.
PMCID: PMC2572140
Quantification of Local Morphodynamics and Local GTPase Activity by Edge Evolution Tracking
Yuki Tsukada, Kazuhiro Aoki, Takeshi Nakamura, Yuichi Sakumura, Michiyuki Matsuda, and Shin Ishii
PLoS Comput Biol. 2008 November; 4(11): e1000223. Published online 2008 November 14. doi: 10.1371/journal.pcbi.1000223.
PMCID: PMC2573959
A Predictive Model of the Oxygen and Heme Regulatory Network in Yeast
Anshul Kundaje, Xiantong Xin, Changgui Lan, Steve Lianoglou, Mei Zhou, Li Zhang, and Christina Leslie
PLoS Comput Biol. 2008 November; 4(11): e1000224. Published online 2008 November 14. doi: 10.1371/journal.pcbi.1000224.
PMCID: PMC2573020
Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman
PLoS Comput Biol. 2008 November; 4(11): e1000225. Published online 2008 November 21. doi: 10.1371/journal.pcbi.1000225.
PMCID: PMC2579584
Neutrality and Robustness in Evo-Devo: Emergence of Lateral Inhibition
Andreea Munteanu and Ricard V. Solé
PLoS Comput Biol. 2008 November; 4(11): e1000226. Published online 2008 November 21. doi: 10.1371/journal.pcbi.1000226.
PMCID: PMC2577890
Order-Based Representation in Random Networks of Cortical Neurons
Goded Shahaf, Danny Eytan, Asaf Gal, Einat Kermany, Vladimir Lyakhov, Christoph Zrenner, and Shimon Marom
PLoS Comput Biol. 2008 November; 4(11): e1000228. Published online 2008 November 21. doi: 10.1371/journal.pcbi.1000228.
PMCID: PMC2580731
Behavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration
Nicolas Maubourguet, Annick Lesne, Jean-Pierre Changeux, Uwe Maskos, and Philippe Faure
PLoS Comput Biol. 2008 November; 4(11): e1000229. Published online 2008 November 21. doi: 10.1371/journal.pcbi.1000229.
PMCID: PMC2581917
Optimal Learning Rules for Discrete Synapses
Adam B. Barrett and M. C. W. van Rossum
PLoS Comput Biol. 2008 November; 4(11): e1000230. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000230.
PMCID: PMC2580035
Structural and Thermodynamic Approach to Peptide Immunogenicity
Carlos J. Camacho, Yasuhiro Katsumata, and Dana P. Ascherman
PLoS Comput Biol. 2008 November; 4(11): e1000231. Published online 2008 November 21. doi: 10.1371/journal.pcbi.1000231.
PMCID: PMC2577884
Age-Dependent Evolution of the Yeast Protein Interaction Network Suggests a Limited Role of Gene Duplication and Divergence
Wan Kyu Kim and Edward M. Marcotte
PLoS Comput Biol. 2008 November; 4(11): e1000232. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000232.
PMCID: PMC2583957
PSICIC: Noise and Asymmetry in Bacterial Division Revealed by Computational Image Analysis at Sub-Pixel Resolution
Jonathan M. Guberman, Allison Fay, Jonathan Dworkin, Ned S. Wingreen, and Zemer Gitai
PLoS Comput Biol. 2008 November; 4(11): e1000233. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000233.
PMCID: PMC2581597
A Methodological Framework for the Reconstruction of Contiguous Regions of Ancestral Genomes and Its Application to Mammalian Genomes
Cedric Chauve and Eric Tannier
PLoS Comput Biol. 2008 November; 4(11): e1000234. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000234.
PMCID: PMC2580819
Multistable Decision Switches for Flexible Control of Epigenetic Differentiation
Raúl Guantes and Juan F. Poyatos
PLoS Comput Biol. 2008 November; 4(11): e1000235. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000235.
PMCID: PMC2580821
Dynamic Changes in Protein Functional Linkage Networks Revealed by Integration with Gene Expression Data
Shubhada R. Hegde, Palanisamy Manimaran, and Shekhar C. Mande
PLoS Comput Biol. 2008 November; 4(11): e1000237. Published online 2008 November 28. doi: 10.1371/journal.pcbi.1000237.
PMCID: PMC2580820
Corrections
Correction: Similarity Queries for Temporal Toxicogenomic Expression Profiles
Adam A. Smith, Aaron Vollrath, Christopher A. Bradfield, and Mark Craven
PLoS Comput Biol. 2008 November; 4(11): 10.1371/annotation/48ea9acf-4422-4792-b9a6-565de3e64f60. Published online 2008 November 25. doi: 10.1371/annotation/48ea9acf-4422-4792-b9a6-565de3e64f60.
PMCID: PMC2597899
Corrects: Adam A. Smith, et al. Similarity Queries for Temporal Toxicogenomic Expression Profiles. PLoS Comput Biol. 2008 July; 4(7): e1000116.
Correction: The Rough Guide to In Silico Function Prediction, or How To Use Sequence and Structure Information To Predict Protein Function
Marco Punta and Yanay Ofran
PLoS Comput Biol. 2008 November; 4(11): 10.1371/annotation/3d8d748f-d1be-4ba9-84b3-23d2a582338b. Published online 2008 November 10. doi: 10.1371/annotation/3d8d748f-d1be-4ba9-84b3-23d2a582338b.
PMCID: PMC2583278
Corrects: Marco Punta, et al. The Rough Guide to In Silico Function Prediction, or How To Use Sequence and Structure Information To Predict Protein Function. PLoS Comput Biol. 2008 October; 4(10): e1000160.
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