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Volume 3(2);  February 2007
Perspectives
From Bytes to Bedside: Data Integration and Computational Biology for Translational Cancer Research
Jomol P Mathew, Barry S Taylor, Gary D Bader, Saiju Pyarajan, Marco Antoniotti, Arul M Chinnaiyan, Chris Sander, Steven J Burakoff, and Bud Mishra
PLoS Comput Biol. 2007 February; 3(2): e12. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030012.
PMCID: PMC1808026
Research Articles
Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology
Stefano Ciliberti, Olivier C Martin, and Andreas Wagner
PLoS Comput Biol. 2007 February; 3(2): e15. Published online 2007 February 2. doi: 10.1371/journal.pcbi.0030015.
PMCID: PMC1794322
Automatic Extraction of Protein Point Mutations Using a Graph Bigram Association
Lawrence C Lee, Florence Horn, and Fred E Cohen
PLoS Comput Biol. 2007 February; 3(2): e16. Published online 2007 February 2. doi: 10.1371/journal.pcbi.0030016.
PMCID: PMC1794323
Efficiency and Cost of Economical Brain Functional Networks
Sophie Achard and Ed Bullmore
PLoS Comput Biol. 2007 February; 3(2): e17. Published online 2007 February 2. doi: 10.1371/journal.pcbi.0030017.
PMCID: PMC1794324
Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning
Gunnar Rätsch, Sören Sonnenburg, Jagan Srinivasan, Hanh Witte, Klaus-R Müller, Ralf-J Sommer, and Bernhard Schölkopf
PLoS Comput Biol. 2007 February; 3(2): e20. Prepublished online 2006 December 21. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030020.
PMCID: PMC1808025
Mechanochemical Coupling in the Myosin Motor Domain. I. Insights from Equilibrium Active-Site Simulations
Haibo Yu, Liang Ma, Yang Yang, and Qiang Cui
PLoS Comput Biol. 2007 February; 3(2): e21. Prepublished online 2006 December 21. Published online 2007 February 9. doi: 10.1371/journal.pcbi.0030021.
PMCID: PMC1796662
Deprotonation by Dehydration: The Origin of Ammonium Sensing in the AmtB Channel
David L Bostick and Charles L. Brooks III
PLoS Comput Biol. 2007 February; 3(2): e22. Prepublished online 2006 December 21. Published online 2007 February 9. doi: 10.1371/journal.pcbi.0030022.
PMCID: PMC1796661
Mechanochemical Coupling in the Myosin Motor Domain. II. Analysis of Critical Residues
Haibo Yu, Liang Ma, Yang Yang, and Qiang Cui
PLoS Comput Biol. 2007 February; 3(2): e23. Prepublished online 2006 December 22. Published online 2007 February 16. doi: 10.1371/journal.pcbi.0030023.
PMCID: PMC1800309
Specificity and Evolvability in Eukaryotic Protein Interaction Networks
Pedro Beltrao and Luis Serrano
PLoS Comput Biol. 2007 February; 3(2): e25. Prepublished online 2006 December 28. Published online 2007 February 16. doi: 10.1371/journal.pcbi.0030025.
PMCID: PMC1797819
Functional Impact of Missense Variants in BRCA1 Predicted by Supervised Learning
Rachel Karchin, Alvaro N. A Monteiro, Sean V Tavtigian, Marcelo A Carvalho, and Andrej Sali
PLoS Comput Biol. 2007 February; 3(2): e26. Prepublished online 2006 December 28. Published online 2007 February 16. doi: 10.1371/journal.pcbi.0030026.
PMCID: PMC1797820
Synonymous Substitution Rates Predict HIV Disease Progression as a Result of Underlying Replication Dynamics
Philippe Lemey, Sergei L Kosakovsky Pond, Alexei J Drummond, Oliver G Pybus, Beth Shapiro, Helena Barroso, Nuno Taveira, and Andrew Rambaut
PLoS Comput Biol. 2007 February; 3(2): e29. Prepublished online 2007 January 2. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030029.
PMCID: PMC1797821
Unsupervised Learning of Visual Features through Spike Timing Dependent Plasticity
Timothée Masquelier and Simon J Thorpe
PLoS Comput Biol. 2007 February; 3(2): e31. Prepublished online 2007 January 2. Published online 2007 February 16. doi: 10.1371/journal.pcbi.0030031.
PMCID: PMC1797822
Repressor Dimerization in the Zebrafish Somitogenesis Clock
Olivier Cinquin
PLoS Comput Biol. 2007 February; 3(2): e32. Published online 2007 February 16. doi: 10.1371/journal.pcbi.0030032.
PMCID: PMC1797823
Assessing the Nature of Lipid Raft Membranes
Perttu S Niemelä, Samuli Ollila, Marja T Hyvönen, Mikko Karttunen, and Ilpo Vattulainen
PLoS Comput Biol. 2007 February; 3(2): e34. Prepublished online 2007 January 5. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030034.
PMCID: PMC1808021
Persistent Activity in Neural Networks with Dynamic Synapses
Omri Barak and Misha Tsodyks
PLoS Comput Biol. 2007 February; 3(2): e35. Prepublished online 2007 January 9. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030035.
PMCID: PMC1808024
Corrections
Correction: Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays
Rameen Beroukhim, Ming Lin, Yuhyun Park, Ke Hao, Xiaojun Zhao, Levi A Garraway, Edward A Fox, Ephraim P Hochberg, Ingo K Mellinghoff, Matthias D Hofer, Aurelien Descazeaud, Mark A Rubin, Matthew Meyerson, Wing Hung Wong, William R Sellers, and Cheng Li
PLoS Comput Biol. 2007 February; 3(2): e40. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030040.
PMCID: PMC1808013
Corrects: Rameen Beroukhim, et al. Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays. PLoS Comput Biol. 2006 May; 2(5): e41.
Correction: The Role of Compensatory Mutations in the Emergence of Drug Resistance
Andreas Handel, Roland R Regoes, and Rustom Antia
PLoS Comput Biol. 2007 February; 3(2): e46. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030046.
PMCID: PMC1808010
Corrects: Andreas Handel, et al. The Role of Compensatory Mutations in the Emergence of Drug Resistance. PLoS Comput Biol. 2006 October; 2(10): e137.
Correction: The Genome: An Outsider's View
Carl Zimmer
PLoS Comput Biol. 2007 February; 3(2): e47. Published online 2007 February 23. doi: 10.1371/journal.pcbi.0030047.
PMCID: PMC1808015
Corrects: Carl Zimmer. The Genome: An Outsider's View. PLoS Comput Biol. 2006 December; 2(12): e156.
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