National Institute on Drug Abuse
Director's Report to the National Advisory Council on Drug Abuse
May, 1999
Program Activities
Program Announcements/RFAs
On April 29, 1999, NIDA issued a Program Announcement entitled Clinical Research Education Programs in Drug Abuse and Addiction (PAR-99-093). This PA invites grant applications to support educational programs aimed at 1) developing the research skills of investigators who wish to focus on clinical, prevention, health services, or treatment issues in drug abuse or 2) developing a cadre of clinical drug abuse experts proficient in the use of research findings to develop or implement early detection, diagnosis, treatment or prevention interventions.
On March 31, 1999, numerous NIH components (including NIDA) and the CDC issued a Program Announcement entitled Research on Ethical Issues in Human Studies (PA-99-079) to solicit grant applications for support to conduct research on ethical issues that arise with research involving human participants.
On April 13, 1999, numerous NIH Institutes (including NIDA) issued a Program Announcement entitled Mentored Quantitative Research Career Development Award (PA-99-087) which is intended to support the career development of investigators with quantitiative scientific and engineering backgrounds outside of biology or medicine who have made a commitment to focus their research endeavors on behavioral and biomedical research (basic or clinical).
On April 20, 1999, NIDA, in conjunction with the National Institute of Mental Health, the National Institute on Alcohol Abuse and Alcoholism, and the National Institute of Environmental Health Sciences issued a Program Announcemnt entitled Individual Predoctoral National Research Service Awards for M.D./Ph.D. Fellowships (PA-99-089). The purpose of the fellowship program described in this announcement is to help ensure that highly trained physician/scientists will be available in adequate numbers and in the appropriate research areas and fields to meet the Nation's mental health, drug abuse and addicion, alcohol abuse and alcoholism, and environmental health sciences research needs.
On March 5, 1999, numerous NIH components (including NIDA) issued an RFA entitled Technologies for Generation of Full-Length Mammalian cDNA (CA-99-005). The purpose of this RFA is to support the development of technologies that will facilitate the generation of a complete set of full-length human cDNAs as well as other mammalian cDNAs. Letter of Intent Receipt date for this RFA was April 6, 1999, and the Application Receipt date was May 13, 1999.
On March 5, 1999, numerous NIH Institutes (including NIDA) issued an RFA entitled Rat Genome Database (HL-99-013). The objective of this RFA is to establish a database that will collect, consolidate, and integrate data generated from ongoing rat genetic, genomic, and related research efforts, and to make these data widely available to the scientific community. Letter of Intent Receipt date for this RFA was April 1, 1999, and the Application Receipt date was April 26, 1999.
On March 8, 1999, numerous NIH components (including NIDA) issued an RFA entitled Centers for Dietary Supplements Research:Botanicals(OD-99-007). The major goal of this RFA is to foster multidisciplinary research in order to develop systematic evaluation of the safety and efficacy of botanicals. Letter of Intent Receipt date for this RFA was April 13, 1999, and the Application Receipt date was May 13, 1999.
On March 16, 1999, NIDA , in conjunction with the NIH Child Abuse and Neglect Workgroup, issued an RFA entitled Research on Child Neglect (OD-99-0006). This RFA solicits investigator-initiated applications for research on child neglect (contrasted to abuse) including but not limited to antecedents and consequences of neglect--socio-emotional and developmental neurobiology (mechanisms of stress system activation on brain anatomic and functional development, ages of vulnerability to neglect on brain development)--the processes and mediators of risk and protective factors, treatment, preventive interventions, and service delivery. Letter of Intent Receipt date for this RFA is June 15, 1999, and the Application Receipt date is September 14, 1999.
On March 31, 1999, NIDA, in conjunction with several other NIH Institutes, issued an RFA entitled Mouse Mutagenesis and Phenotyping: Nervous System and Behavior (MH-99-007). The purpose of this RFA is to establish facilities for large-scale mutagenesis and phenotyping of nervous system functions and complex behaviors in the laboratory mouse. Neuroscience-focused mutagenesis and phenotyping facilities established by this RFA are expected to serve as a national resource by producing a bank of mouse strains that harbor a wide range of mutations affecting murine nervous system function and behavior. Data and biomaterials produced in projects supported under this RFA will be made widely available to the scientific community. Receipt date for this RFA is August 2, 1999, and the Application Receipt date is October 14, 1999.
Other Program Activities
Training Program in Medications Development for Drugs of Abuse
The Medications Development Division will award its first training grant ("Training Program in Medications Development for Drugs of Abuse, T32 DA07312, PS 140), beginning July 1, 1999, to Dr. Alexandros Makriyannis, a professor of Medicinal Chemistry and Molecular and Cell Biology at the University of Connecticut. The program is designed to train four predoctoral and four postdoctoral trainees in the first year, with additional students and postdoctoral fellows being added to the program in subsequent years. The training will offer traditional medicinal chemistry, combined with high throughput and combinatorial approaches currently utilized in the pharmaceutical industry, as well as the pharmacological and clinical aspects of drug development. The State of Connecticut recently built the Center for Drug Discovery at the University of Connecticut in support of the University's longstanding academic commitment to drug and alcohol abuse research. The collaborations which the Center has with Brookhaven National Laboratory, the Torrey Pines Institute, Bristol-Myers Squibb, Pfizer, and other companies within the private sector who will make their laboratories available for training purposes, will provide a unique training opportunity for the students and postdoctoral fellows being trained under this grant.
NIDA/Somerset Pharmaceuticals CRADA
NIDA and Somerset Pharmaceuticals have executed a Letter of Intent for a Cooperative Research and Development Agreement to conduct clinical testing of selegilene in both immediate release and transdermal patch formulations, as a potential pharmacotherapy for the treatment of cocaine dependence.
Buprenorphine Office-Based Study
The Medications Development Division is conducting a Buprenorphine Office-Based Study. This is an open label study that will be conducted in six states (San Antonio, Texas; New York, New York; Chicago, Illinois; Tampa, Florida; Los Angeles, California; and Seattle, Washington). A total of six hundred patients will be enrolled. Investigator meetings have been held in Seattle and New York. An investigator meeting is slated for mid-May in Los Angeles. The trial is scheduled to start enrolling patients in the 2nd Quarter of 1999. The study will evaluate opiate abuse treatment using buprenorphine/naloxone in settings other than the traditional narcotic treatment programs. Information will be obtained to: 1) assess the safety of expanding buprenorphine/naloxone treatment to an adolescent population; 2) develop and test materials, for physicians, that will be useful in training courses by professional societies, and 3) allow labeling changes for induction, maintenance and detoxification regimens using buprenorphine/naloxone in 600 patients.
Amantadine and Disulfiram Reviews
The Medications Development Division held a consultant review of two medications and clinical data (Amantadine and Disulfiram) on April 26 preparatory to future clinical development plans. Data on these two compounds was developed by NIDA P-50 Medications Development Center grantees.
Lofexidine Meeting
On April 7, MDD and Britannia Pharmaceuticals/Forum Products participated in an end of Phase II meeting with the FDA regarding lofexidine, an alpha adrenergic agonist for the treatment of opiate withdrawal. Comments were received regarding the lofexidine development plan.
NIDA/IRP Summer Research Program for Students
Since 1986, the IRP has had a summer research program for students. During the summer of 1998, a total of 41 students representing 35 high schools, colleges, and medical and graduate schools participated in the program through either the NIH Summer Internship Program or the Minority Research and Training Program. Each student participant was assigned to work with an IRP scientist on a research project. The students' training program is individually developed and includes directed readings, tutorials, attendance at seminars, and actual laboratory experience under the direction of the scientist. The culmination of the summer program is the students' presentation of their research at the NIH Student Poster Session held at the Bethesda campus in early August. Because of outstanding contributions and effort, some students will be co-authors on published papers or abstracts. The NIH Summer Internship Program is coordinated by Dr. Stephen Heishman, and the Minority Research and Training Program is coordinated by Dr. Jean Cadet and Ms. Mary Affeldt.
NIDA's New and Competing Continuation Awards Since February 1999
Avants, Sandra A. --- Apt Foundation
Reducing HIV Risk in Methadone-Maintained Patients
Bannon, Michael J. ---Wayne State University School of Medicine
Cocaine Binding Dopamine Transporter: Molecular Biology
Bellack, Alan S. ---University of Maryland
The Process of Change in Drug Abuse by Schizophrenics
Berridge, Craig W. --- University of Wisconsin
Neurochemistry of Amphetamine Induced Arousal
Bickel, Warren K. --- University of Vermont
Impulsivity in Drug Dependence: Delay Discounting
Bidlack, Jean M. --- University of Rochester
Partial Opioids: Potential Treatments for Cocaine Abuse
Biglan, Anthony --- Oregon Research Institute
Low-Cost Prevention of Conduct Disorders
Booth, Robert E. --- University of Colorado
HIV Risk in Drug Users: Relapse and Maintenance Behavior
Brook, David --- Mount Sinai School of Medicine
AIDS Risk: Puerto Rican IDU Fathers and Their Children
Cadoret, Remi J. --- University of Iowa-College of Medicine
Gene-Environment Interaction in Etiology of Drug Abuse
Caine, Barak S. --- Mclean Hospital
Cocaine Self-Administration in Dopamine 'Knockout' Mice
Calloway, Michael --- University of North Carolina at Chapel Hill
Predictors of SA - MH Program Linkages
Carroll, Frank I. --- Research Triangle Institute
Development of Ligands for Nicotinic Receptors
Chavkin, Charles --- University of Washington
Models of Opioid Receptor Desensitization Mechanisms
Chow, Sherry H. --- University of Arizona
Direct Nose-Brain Drug/Peptide Transport
Cicero, Theodore J. --- Washington University
Opiate-Endocrine Interactions-Developmental Aspects
Cochrane, Carolyn E. --- Medical University of South Carolina
Career/Training in Drug Abuse Research
Comer, Sandra D. --- Research Foundation Mental Hygiene, Inc.
Buprenorphine Abuse by Humans: Laboratory Studies
Compton, Wilson M. --- Washington University
Over-the-Counter Syringe Purchase in Five Communities
Connors, Barry W. --- Brown University
Nicotinic Mechanisms in Sensory Neocortex
Cook, Royer F. --- ISA Associates Inc.
A Workplace CD-ROM Drug Prevention Program for Parents
Derrick, Brian E. --- University of Texas
Associative LTP of Area CA3 in the Hippocampus In Vivo
Deutsch, Howard M. --- Georgia Institute of Technology
Preclinical Development of Drugs for Stimulant Abuse
Duncan, Gary --- University of North Carolina-Office of Grants and Contracts
Elementary School Neuroscience Literacy
El-Bassel, Nabila --- Columbia University
HIV Risk and Partner Violence: Men on Methadone
Ellickson, Phyllis I. --- Rand Corporation
HIV Risk, Drugs, and Violence
Elliot, Diane I. --- Oregon Health sciences University
School-Based Drug Use Prevention for Girl Athletes
Epstein, Jennifer A. --- Cornell University-/Weill Medical College
Predictors of Adolescent Drug Use among Inner-city Youth
Evins, Eden A. --- Massachusetts General Hospital
Smoking Cessation in Schizophrenia
Fields, Howard I. --- University of California
Neural Substrate of Opiate Analgesia
Fisher, Philip A. --- Oregon Social Learning Center
Indian Wellness Preventive Intervention Project
France, Charles P. --- Louisiana State University Medical Center
Behavioral Pharmacology of Opioids
France, Charles P. --- Louisiana State University School of Dentistry
Discriminative Effects of Benzodiazepine Withdrawal
Freeborn, Donald K. --- Kaiser Foundation Hospitals
Drug Abuse Treatment Costs of Medicaid Clients in an HMO
Frost, James J. --- Johns Hopkins University
Brain Opioid Receptors and Cognition in Cocaine Abuse
Galanter, Marc --- New York University School of Medicine
Network Therapy Development, Stage II with Buprenorphine
Gallagher, Joel P. --- University of Texas Medical Branch
CRF Mechanisms and Cocaine
Gariti, Peter --- University of Pennsylvania
Combining a Smoke Ending Aid with Behavioral Treatment
Geyer, Mark A. --- University of California-San Diego
Monoamine and Hallucinogen Effects on Rodent Behavior
Ghasemzadeh, Mohammadhossein B. --- Washington State University
R03: Glutamate Receptor and Chronic Cocaine
Glassco, William S. --- Virginia Commonwealth University
Synthetic Exploration of Central Nicotinic Receptors
Glennon, Richard A. --- Virginia Commonwealth University
Chemical/Behavioral Studies on Hallucinogenic Agents
Goeders, Nicholas E. --- Louisiana State University Medical Center School of Medicine
Environmental Influences on Cocaine Self-Administration
Gollub, Randy I. --- Massachusetts General Hospital East
FMRI of Cocaine Effects in Cocaine Abusing Schizophrenic
Griffiths, Roland R. --- Johns Hopkins Bayview Medical Center
Benzodiazepines Use/Abuse: Effects on Memory Mechanisms
Hagan, Holly C. --- Seattle-King County Public Health Department
Hepatitis C in IDUs: Epidemiology and Prevention
Hammond, Donna I. --- University of Chicago
Effect of Inflammatory Nociception on Medullary Neurons
Harris, Debra S. --- University of California
Effects of Cortisol on Human Methamphetamine Response
Hogue, Aaron T. --- Fordham University
Family Change Mechanisms in Adolescent Drug Use Therapy
Hughes, John R. --- University of Vermont and State Agricultural College
Evaluation of a Cigarette Substitute
Inciardi, James A. --- University of Delaware
HIV/AIDS Risk Reduction among Drug-Involved Probationers
Inturrisi, Charles E. --- Cornell University Medical College
Glutamatergic Systems in Pain and Opioid Action
Jevtovic-Todorovic, Vesna --- Washington University
Psychotic and Analgesic Actions of NMDA Antagonists
Johnson, Bankole A. --- University of Texas Health Science Center
Cocaine Brain Effects and Neuroimaging
Johnson, Kenneth M. --- University of Texas Medical Branch
Neurochemical Pharmacology of Phencyclidine
Kalyuzhny, Alexander E. --- University of Minnesota
Opioid-GABA Interactions and Antinociception
Kaplan, Howard B. --- Texas A&M University
Drug Abuse and Other Deviant Adaptations to Stress
Kelley, Ann E. --- Wisconsin Psychiatric Institute and Clinic
Opioid Systems in Ventral Striatum and Food Reward
Kharasch, Evan D. --- University of Washington
Opioids in Cancer Pain and Drug Abuse: Optimizing Therapy
Kidorf, Michael S. --- Johns Hopkins Bayview Medical Center
Community-Based Intervention at Needle Exchange Sites
Kinnunen, Taru --- Harvard School of Dental Medicine
Exercise and Nicotine Replacement for Female Smokers
Knuepfer, Mark M. --- Saint Louis University
Cardiovascular Effects of Cocaine
Kolesnikov, Yuri A. --- Sloan-Kettering Institute-Cancer Research
Opioid and Non-Opioid Mechanism(s) of Neuropathic Pain
Koob, George F. --- Scripps Research Institute
Neuronal Substrates of Cocaine Reward
Kuhar, Michael J. --- Emory University
Mechanisms of Drugs of Abuse
Kuhn, Donald M. --- Wayne State University
The Neurotoxicity of Amphetamines and Related Stimulants
Langenbucher, James W. --- Rutgers State University of New Jersey
Neuroadaptive Clinical Models of Drug Dependents
Lennox, Richard D. --- Piedmont Research Institute, Inc.
The Impact of State Continuum-of-Care Mandates
Levine, Allen S. ---VA Medical Center
The Effect of Sucrose and/or Fat Ingestion on Opiods
Levin, Edward D. --- Duke University
Attention as a Target of Intoxication
Lindberg, Iris --- Louisiana State University Medical Center
Opioid Peptide Synthesizing Enzymes
Liu-Chen, Lee-Yuan --- Temple University School of Medicine
Regulation of Kappa Opioid Receptors
Lluedtke, Robert R. --- University of North Texas Health Science Center
Therapeutics for Cocaine Dependence: Natural Products
Lukas, Scott E. --- Alcohol and Drug Abuse Research Center
Medication Development for Cocaine Abuse: CDP-Choline
Mackler, Scott A. --- VA Medical Center
Nac-1, a Cocaine-Regulated MRNA in the Rat Brain
Makriyannis, Alexandros --- University of Connecticut
Dopamine Transporter Ligands as Cocaine Medications
Malison, Robert T. --- Yale University School of Medicine
Advanced Training in Spectrum/PET Neuroreceptor Imaging
Margolin, Arthur --- Substance Abuse Treatment Center
Optimizing Auricular Acupuncture for HIV+ Drug Abusers
Marks, Michael J. --- University of Colorado
Alpha-Conotoxin MII: A Selective Nicontinic Receptor Problem
Marshall, John F. --- University of California-Irvine
Methamphetamine Abuse and Cortical Cell Injury
Martin, Billy R. --- Temple University School of Medicine
College on Problems of Drug Dependence Meeting
Masson, Carmen I. --- University of California-San Francisco
Prevention of Infectious Disease in Injection Drug Users
McCance-Katz, Elinore --- Montefiore Medical Center
Opioids and HIV Medications-interactions in Drug Abusers
Mendelson, John --- University of California
Clinical Pharmacology of Methamphetamine Stereoisomers
Meyer, Jerrold S. --- University of Illinois-@uc-Department of Veterinary Biosciences
Receptors for Abused Drugs: Development and Plasticity
Morgenstern, Hal --- University of California-Los Angeles
Marijuana Use and the Risks of Lung and Other Cancers
Morrow, Kathleen M. --- Brown University
Reducing HIV Risk in Substance Abusing Women: A Pilot
Murphy, Sheigla ---Institute for Scientific Analysis
An Ethnography of Victimization, Pregnancy and Drug Use
Musto, David F. --- Yale University
American Women and Substance Abuse 1865-1980
Najavits, Lisa M. --- Mclean Hospital
The Efficacy of Psychosocial Therapies for Drug Abuse
Napier, Celeste T. --- Loyola University Chicago
Opioids and the Physiology of the Ventral Pallidum
Neaigus, Alan --- National Development and Research Institute
Non-Injecting Heroin Users, New Injectors and HIV Risk
Nemoto, Tooru --- University of California-San Francisco
HIV-Related Behaviors in Hard to Reach High Risk Men
Nestler, Eric J. --- Yale University School of Medicine
Molecular Studies of Opiate and Cocaine Action in Brain
Olsen, George D. --- Oregon Health Sciences University
Mortphine-6 Glucuronide: Development of Breathing Control
Page, John B. --- University of Miami School of Medicine
Drug Use and Gang Activity among Haitian Youths
Perlman, David C. --- Beth Israel Medical Center
TB Screening and Prevention in Active Users
Porreca, Frank --- Arizona Health Sciences Center
Bifunctional Opioid/CCK Ligands for Pain
Proudfit, Herbert K. --- University of Illinois
Pharmacologic Studies of CNS Pain Molulatory Systems
Raso, Victor A. --- Boston Biomedical Research Institute
Vaccine to Elicit Catalytic Anti-Cocaine Antibodies
Rayport, Stephen G. --- Columbia University
Psychostimulant Sensitization at the Synaptic Level
Rebec, George V. --- Indiana University
Neuropharmacology of Drugs of Abuse: Amphetamine
Renshaw, Perry F. --- Mclean Hospital
Magnetic Resonance, EEG and Behavior after Cocaine
Ricaurte, George A. --- Johns Hopkins University
Studies of Substituted Amphetamine Neurotoxicity
Richter, Anke --- Research Triangle Institute
Extended Economic Impact Assessment of AIDS Intervention
Rosenberg, Gary --- Mount Sinai School of Medicine
Drug Use: Generational Transmission in Minority Youth
Rose, Jed E. --- Duke University Medical Center
Scaling the Reinforcing Value of Cigarette Smoke
Roy, Sabita --- VA Medical Center
Role of Mu-Opioid Receptor in Immune Function
Rubenstein, John I. --- University of California
NKX Homeobox Gene Regulation of Ventral CNS Development
Sadee, Wolfgang --- University of California-San Francisco
Opioid Receptor Regulation
Schenk, James O. --- Washington State University
Drugs of Abuse and Dopamine Release and Reuptake
Sharp, Burt M. --- University of Tennessee
Interaction between Nicotine and Stress
Siggins, George R. --- Scripps Research Institutes
Morphine-like Brain Peptides--Cellular Neurobiology
Simon, Eric J. ---New York University Medical Center
Biochemical Research on Opioid Receptors
Simon, Eric J. ---New York University Medical Center
30th Annual International Narcotics Research Conference
Singer, Merrill --- Hispanic Health Council
Syringe Access and HIV Risk
Smith, James E. --- Bowman Gray School of Medicine
Center for Neurobiological Investigation of Drug Abuse
Sorg, Barbara A. --- Washington State University
Cortical Regulation of Sensitization
Spealman, Roger D. --- Harvard Medical School
Behavior Controlled by Drug Injections
Szapoznik, Jose --- University of Miami
Structural Ecosystems Treatment with Drug using Minority Youth
Tashkin, Donald P. --- UCLA Department of Medicine
Pathophysiologic Consequences of Smoked Substance Abuse
Thayer, Stanley A. --- University of Minnesota
HIV Neurotoxicity: Mechanism and Modulation Y Canabinoids
Vezina, Paul --- University of Chicago
Glutamate and the Self Administration of Amphetamines
Waldron, Holly B. --- University of New Mexico
Resistant Adolescent Substance Abusers in Treatment
Weber, Richard J. --- University of Illinois
Neuroendocrine-Immune Correlates of Self-Administered Heroin
Wilcox, George I. --- University of Minnesota
Spinal Mechanisms of Opioid Tolerance
Wilens, Timothy E. --- Massachusetts General Hospital
Long-Term Drug Abuse in ADHD
Williams, Mark I. --- Nova Research Company
Condom Use Among Drug Users Receiving Antiretrovirals
Wilson, Marlene A. --- University of South Carolina
Gender Differences in the Brain and Behavior
Wilson, William H. --- Duke University Medical Center
Early Use of Marijuana and Brain Morphology and Function
Winkleby, Marilyn A. --- Stanford University School of Medicine
High Risk Teen Tobacco Use Prevention through Advocacy
Yurgelun-Todd, Deborah A. --- Mclean Hospital
Residual Cognitive Effects of Cannabis: An FMRI Study
Yu, Xiao-Fang --- Johns Hopkins University School of Public Health
Viral Determinants of Disease Progression in HIV+IDUs
Zacny, James P. --- University of Chicago
Behavioral Effects of Opioids in Volunteers
Zahniser, Nancy R. --- University of Colorado Health Sciences Center
Cocaine Sensitization and the Dopamine Transporter
Zarkin, Gary A. --- Research Triangle Institute
Benefits of Treatment Services
Review Activities
Staff Development
In January 1999, Drs. Teresa Levitin, and William C. Grace presented at the NIH Peer Review Oversight Group to discuss a model for web based training of reviewers. This training model was developed in conjunction with Drs. Marina Volkov and Susan Coyle of OEPR, and the web pages are currently under construction.
In March 1999, Dr. Mark Swieter, Scientific Review Administrator, completed reviews for applications for the Human Brain Project, a government-wide initiative designed to encourage and support investigator-initiated neuroinformatics research that will lead to new digital and electronic tools for all domains of brain and behavioral research reflecting normal and disease states across the lifespan. Participating agencies include 10 institutes of the NIH (including NIDA), the National Library of Medicine, the Fogarty International Center, the National Science Foundation, the National Aeronautics and Space Administration, the Office of Naval Research, and the Department of Energy.
For additional information about NIDA send e-mail to Information@nida.nih.gov
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