This program is comprised of grants focused on the application of technology used to measure large scale integrated metabolism of cells, tissues and organ system. These studies can be done in vivo, in isolated tissue or in cell culture. They have a focus on applying novel technology advancements in measuring and identifying many metabolites within multiple pathways. Emphasis is on the discovery of new potentially mechanistic relationships between metabolite profile changes and the etiology or pathology of specific metabolic diseases or syndromes that falls within NIDDK’s scope of research. Important goals include in vivo and translational potential of technology to rapidly analyze and interpret large networks of pathways and fluxes to further a complete view of metabolome dynamics.
For more information, contact Dr. Arthur Castle, Director, Metabolomics and Informatics Programs.
