Selection by analysis type | Selection by disease class | List entities for hot spot | ||
---|---|---|---|---|
Publications with Comparative Genomic Hybridization (CGH) data | Entities according to ICD-O 3 | |||
Publications with array/matrix CGH data (BAC, oligonucleotide, cDNA, SNP; whole genome) | Disease loci (e.g. all gastric tumors) | |||
Tumor-cytogenetic publications, mostly linking to the "Mitelman Database of Chromosome Aberrations in Cancer" | Compound groups, (e.g. prostate ca. as "adenocarcinoma" with locus "prostate gland") |
The Progenetix database provides an overview of copy number abnormalities in human neoplasias, chiefly derived from Comparative Genomic Hybridization (CGH) experiments. As a curated database, it collects genomic gain/loss information of individual cancer and leukemia cases, published in peer reviewed articles.
Progenetix is with 17236 CGH and 2563 array CGH experiments the largest public database for interpreted ("called") whole genome CGH profiles. Additionally, the website provides a comprehensive listing of publications referring to original (a)CGH experiments. Progenetix users are encouraged to provide (a)CGH data, and to promote further submissions. The software and database content are maintained by Michael Baudis at the University of Zürich.
Related publications
Baudis, M. 2007. Genomic imbalances in 5918 malignant epithelial tumors: An explorative meta-analysis of chromosomal CGH data. BMC Cancer 7:226 [PDF]
Baudis, M. 2006. Online database and bioinformatics toolbox to support data mining in cancer cytogenetics. Biotechniques 40, no. 3: 296-272. [PDF]
Baudis, M, and ML Cleary. 2001. Progenetix.net: an online repository for molecular cytogenetic aberration data. Bioinformatics 12, no. 17: 1228-1229. [PDF]