NCTR Research Highlight - January 9, 2009
Modernizing Tools for Safety Assessment –
Fifty
scientists from the FDA, EPA, CDC, and NIH convened at the 2nd
Inter-Agency Computational Toxicology Colloquium held at NCTR on
December 10 and 11, 2008. Three major initiatives were selected for
development into cross-agency research proposals:
·
Development of in
silico compound screening and prioritization models for liver
toxicity in both animals and humans
·
Development of
high-throughput screening data-based approach for chemical mixture
component grouping, toxicity endpoint prediction, and risk/safety
assessment
·
Use of high-information
content data, such as microarray data, to predict individual
susceptibilities and population risk to chemicals and drugs
Written proposals for the in silico modeling and draft
documents for chemical mixtures analysis initiatives are circulating
among participant agencies for comment.
For more
information, contact Dr. William Slikker, Director, NCTR, or Dr. James
Fuscoe, Division of Systems Toxicology, NCTR.
Research Highlight History
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