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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Andrea Bucceri
Welcome to BMC Chemical Biology published by BioMed Central
BMC Chemical Biology is an open access journal publishing original peer-reviewed research articles in the application of chemistry to the investigation of biology and drug design.
BMC Chemical Biology (ISSN 1472-6769) is indexed/tracked/covered by PubMed, BIOSIS, CAS, Scopus, EMBASE and Google Scholar.
BMC Chemical Biology 2008, 8 :3
The analysis of separate components of cellular growth dynamics allows a sophisticated assessment of the effect of drug-drug and drug-gene interactions upon cells, and may help characterize the physiological impact of orphan bioactive compounds.
BMC Chemical Biology 2008, 8 :2
Inducing apoptosis using compounds screened from a chemical library demonstrates that calcium signaling is generally not an early event and suggests that the calmodulin kinase II pathway is often important in sustaining apoptosis.
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Research article
Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus John Paul Pezacki, Selena M Sagan, Angela M Tonary, Yanouchka Rouleau, Sylvie Belanger, Lubica Supekova, Andrew I Su BMC Chemical Biology 2009, 9 :2 (16 [Abstract ] [Provisional PDF ]
Research article
Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue Patrick Chene, Joelle Rudloff, Joseph Schoepfer, Pascal Furet, Peter Meier, Zhiyan Qian, Jean-Marc Schlaeppi, Rita Schmitz, Thomas Radimerski BMC Chemical Biology 2009, 9 :1 (7 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Chemogenetic fingerprinting by analysis of cellular growth dynamics Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg BMC Chemical Biology 2008, 8 :3 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II Maria H BMC Chemical Biology 2008, 8 :2 (1 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae Lorena Norambuena, Jan Zouhar, Glenn R Hicks, Natasha V Raikhel BMC Chemical Biology 2008, 8 :1 (7 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Enhancement of intracellular Yuichiro Tanaka, Leslie A Lesoon Wood, Robert V Cooney BMC Chemical Biology 2007, 7 :2 (3 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
The effect of amino acid deletions and substitutions in the longest loop of GFP Gabriela Flores-Ram BMC Chemical Biology 2007, 7 :1 (26 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Studies on the synthesis, characterization, binding with DNA and activities of two cis -planaramineplatinum(II) complexes of the form: cis -PtL(NH3 )Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine Ahmed Abdullah, Fazlul Huq, Ashraf Chowdhury, Hasan Tayyem, Philip Beale, Keith Fisher BMC Chemical Biology 2006, 6 :3 (13 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol Zoltan Maliga, Timothy J Mitchison BMC Chemical Biology 2006, 6 :2 (27 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator Justin J Heynekamp, Lucy A Hunsaker, Thomas A Vander Jagt, Lorraine M Deck, David L Vander Jagt BMC Chemical Biology 2006, 6 :1 (8 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis Danielle Kemmer, Lianne M McHardy, Shawn Hoon, Delphine Reberioux, Guri Giaever, Corey Nislow, Calvin D Roskelley, Michel Roberge BMC Microbiology 2009, 9 :9 (14 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2
Olena Perlova, Klaus Gerth, Silvia Kuhlmann, Youming Zhang, Rolf Muller Microbial Cell Factories 2009, 8 :1 (6 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Detergent resistant membrane-associated IDE in cultured cells and brain tissue: Relevance to Abeta and insulin degradation Ayelen Bulloj, Maria C Leal, Ezequiel I Surace, Xue Zhang, Huaxi Xu, Maria D Ledesma, Eduardo M Castano, Laura Morelli Molecular Neurodegeneration 2008, 3 :22 (31 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code Harold S Bernhardt, Warren P Tate Biology Direct 2008, 3 :53 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma Adrien Daigeler, Christina Brenzel, Daniel Bulut, Anne Geisler, Christoph Hilgert, Marcus Lehnhardt, Hans U Steinau, Annegret Flier, Lars Steinstraesser, Ludger Klein-Hitpass, Ulrich Mittelkoetter, Waldemar Uhl, Ansgar M Chromik Journal of Experimental & Clinical Cancer Research 2008, 27 :82 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
MetaboMiner Jianguo Xia, Trent C Bjorndahl, Peter Tang, David S Wishart BMC Bioinformatics 2008, 9 :507 (28 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Highly sensitive feature detection for high resolution LC/MS Ralf Tautenhahn, Christoph Bottcher, Steffen Neumann BMC Bioinformatics 2008, 9 :504 (28 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Prediction of specificity-determining residues for small-molecule kinase inhibitors Daniel R Caffrey, Elizabeth A Lunney, Deborah J Moshinsky BMC Bioinformatics 2008, 9 :491 (25 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Displacement affinity chromatography of protein phosphatase one (PP1) complexes Greg BG Moorhead, Laura Trinkle-Mulcahy, Mhairi Nimick, Veerle De Wever, David G Campbell, Robert Gourlay, Yun Wah Lam, Angus I Lamond BMC Biochemistry 2008, 9 :28 (10 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications Wolfgang W Quitschke BMC Biotechnology 2008, 8 :84 (6 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
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