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Research
Cartilage Biology and Orthopaedics Branch
Rocky Tuan, Ph.D.
Chief, Cartilage Biology and Orthopaedics Branch
Phone: (301) 451-6854
Fax: (301) 435-8017
E-mail: tuanr@mail.nih.gov
The Cartilage Biology and Orthopaedics Branch conducts basic and clinical research directed towards understanding the mechanisms regulating cartilage function and the basis of cartilage and orthopaedic diseases, and the development of functional cartilage tissue substitutes. The researchers in the Cartilage Biology and Orthopaedics Branch are using cellular, molecular, and genetic approaches to analyze cartilage development, growth, diseases and aging, as well as applying the emerging technology of mesenchymal stem cell-based tissue engineering for functional cartilage replacement. There are three interactive research sections within the Branch: Developmental Biology, Orthopaedics, and Tissue Engineering.
- Cartilage Molecular Genetics Group — Group Leader, David Hall, Ph.D.
- Developmental Biology Section — Acting Chief, Rocky Tuan, Ph.D.
- Orthopaedics Section — Acting Chief, Rocky Tuan, Ph.D.
- Tissue Engineering Section — Acting Chief, Rocky Tuan, Ph.D.
Selected Publications
Song, L., Webb, N.E., Song, Y.J. and Tuan, R.S. (2006) Identification and functional analysis of genes regulating mesenchymal stem cell self-renewal and multipotency. Stem Cells. 24: 1707-1718.
Mauck, R.L., Yuan, X., and Tuan, R.S. (2005) Chondrogenic differentiation ad functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthr. Cart., 14: 179-189.
Li WJ, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials. 2005; 26(6): 599-609.
Li WJ, Tuli R, Huang X, Laquerriere P, Tuan RS. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials. 2005; 26(25): 5158-66.
Haleem-Smith, H., Derfoul, A., Okafor, C., Tuli, R., Olsen, D., Hall, D.J., and Tuan, R.S. (2005) Optimization of high efficiency transfection of adult human mesenchymal stem cells in vitro. Mol. Biotechnol. 30: 9-20.
See complete list of publications
Updated January 17, 2008
