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| Spotlight on Joost Oppenheim, M.D. |
09/08 |
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| Eliminating the suppressive elements of the immune system combined with better vaccine stimulation of the antitumor response may be a winning combination in defending against cancer, according to Joost Oppenheim, M.D., Chief of the Laboratory of Molecular Immunoregulation. Such "immune approaches" |
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| Spotlight on Melinda Hollingshead, DVM, PhD |
08/08 |
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| Melinda Hollingshead, DVM, Ph.D., has often taken the road less traveled and that has made all the difference for her—and for many others. Speaking of the events that led her to becoming chief of the Biological Testing Branch, she commented, "My whole life, a pathway opens up and I walk down it." |
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| Spotlight on Elizabeth and Michael Baseler |
04/08 |
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| She manages the Clinical Monitoring Research Program. He manages the Applied and Developmental Directorate. Together, Elizabeth Baseler, M.S., and husband Michael Baseler, Ph.D., provide the vision for these programs that underpin much of the clinical research and development at the National Cancer Institute (NCI) and the National Institute for Allergy and Infectious Diseases (NIAID). And their focus is single-minded: it’s all about the patients. |
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| Spotlight on Nancy Colburn, Ph.D. |
02/08 |
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| You may have noticed a tall, slender redhead with an athletic build, easy smile, and a light step around campus: Dr. Nancy Colburn, Chief of the Laboratory of Cancer Prevention (LCP), part of the Center for Cancer Research (CCR), NCI-Frederick.
Talk with Dr. Colburn a few minutes, and you'll also realize here is an accomplished woman with varied interests, whether it's researching molecular targets for cancer prevention, running up a steep mountain trail for exercise, or trekking to a remote location for vacation. |
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| Spotlight on Stephan Stern, PhD |
11/07 |
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| Nanotechnology holds many promises for the treatment and diagnosis of cancer. New targeted strategies offer reduced side effects, enhanced effectiveness for therapeutics, as well as earlier diagnosis. The Nanotechnology Characterization Laboratory (NCL) at NCI-Frederick is helping to refine and accelerate the implementation of these nanotechnology concepts. Stephan Stern is a key component of that process. |
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| Spotlight on Jeanne Herring, V.M.D. |
09/07 |
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| Not many people have known from childhood what they wanted to do. However, Jeanne Herring, V.M.D., head of the Laboratory Animal Medicine (LAM) program at NCI-Frederick, is one such person. |
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| NCI-Frederick Media Laboratory: Food for Thought |
07/07 |
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| The bottles and jars are neatly stacked on shelves around the laboratory, and the work is carried out quietly and efficiently. In addition to the computer, one of the key pieces of support equipment is the “recipe box,” which holds the most frequently used protocols, and which the technicians consult on a regular basis. Ingredients are measured, combined, heated, or autoclaved, according to protocol, then poured off into vials or Petri dishes and delivered to the requesters. |
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| Nadya Tarasova, PhD |
05/07 |
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| It's always been a question of pathways for Nadya Tarasova. The most recent pathway to gain her attention is the hedgehog pathway that is essential for stem cell renewal and is dysregulated in many cancer types. |
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| Tim Harris, Ph.D. |
03/07 |
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| A few years ago, Dr. Tim Harris had an awakening of sorts. He found that because of the time needed to make a return on investment, the biotechnology industry is usually only interested in genetics and genomics as they relate to developing compounds for clinical use. He realized that to do what he liked, he would have to look beyond private enterprise. |
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| Behind the Scenes at the Scientific Library |
02/07 |
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| Need a journal article? Visit the Scientific Library. Need a quiet place to study? Use one of the Scientific Library's carrels. Want to practice an oral presentation? Use the library's private study room, supplied with audio-visual equipment. Want to know how often an article has been cited or someone has been published? Call the library. |
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| Dr. Barry Gause |
01/07 |
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| Been There, Done That: Now Let Me Help You Do That!
Dr. Barry GauseSometimes retirement isn't what it used to be. For Dr. Barry Gause, it's simply a change of hats. Formerly a clinical investigator for NCI's Medical Oncology Program, he now is Director of the Clinical Research Directorate (CRD), SAIC-Frederick, Inc.'s newest directorate. |
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| Tom Stackhouse, Ph.D. |
12/06 |
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| Tom Stackhouse may be working at a desk these days, but he is no stranger to life as a research scientist. With a Ph.D. in biochemistry, he began his career at a pharmaceutical company before coming to work at SAIC-Frederick, Inc., in 1991 as a senior scientist in the Laboratory of Immunobiology. In partnership with Dr. Bert Zbar and an international team of scientists, he assisted in cloning a tumor suppressor gene. |
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| Victor Marquez |
10/06 |
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| “Collaboration” is now a commonplace buzzword, used across the spectrum of society—in business, in education, in social ties, and in science. Indeed, Dr. John Niederhuber, Acting Director for the National Cancer Institute, strongly encourages collaborations with various intra- and extramural entities. |
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| Tom Gannon-Miller |
08/06 |
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| He looks like a baseball player. Tall. Lanky. Clean cut. In fact, that was one of his dreams growing up in Rockville, Maryland. But when he was still in high school, a severe knee injury permanently benched him. Today, Tom Gannon-Miller steps up to the plate every day as manager of Protective Services, and he is as focused on his responsibilities as any ball player is on the ball. |
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| Spotlight on Take Your Child to Work Day |
07/06 |
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| All day, the heavy, ominous clouds, humidity and 90-degree heat threatened thunderstorms. Luckily, for the more than 300 children attending the ninth annual Take Your Child to Work Day on July 12, the storms held off until late evening. |
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| Mikhail Kashlev, Ph.D. |
05/06 |
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| “Just imagine” seems to be Dr. Mikhail Kashlev’s favorite expression, often said with awe and enthusiasm as he contemplates taking a well-known premise one step further or finding a simpler, more efficient way to do something. Dr. Kashlev and his staff have begun to more precisely identify transcription elongation factors through studies of TFIIS (a transcript cleavage factor that rescues elongation complexes arrested within the genes), RSC (a 15-protein complex), and FACT (the nucleosome chaperone). |
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| Philipp Kaldis, Ph.D. |
04/06 |
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| Good science requires a life-long love of learning, a willingness to take risks, and lots of interaction with other scientists. These elements underlie the research advances made by Dr. Philipp Kaldis and his team (Cell Cycle Section, Mouse Cancer Genetics Program). |
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| Alberta Peugeot |
03/06 |
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| While in many ways she shares Forrest Gump’s optimistic outlook, finding delight and surprise in unexpected things, Alberta Peugeot’s take on life goes a step beyond. “Life is a schoolhouse,” she’s fond of saying. And she means it. She never stops learning and taking on new challenges, such as the National Cancer Institute at Frederick. |
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| Jeffrey Strathern, Ph.D. |
02/06 |
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| Jeffrey Strathern, Ph.D., Deputy Director of the Center for Cancer Research since August 2005, and Chief of the Gene Regulation and Chromosome Biology Laboratory (GRCBL), has long been a proponent of interactivity. In a recent interview, he noted that “One of the best aspects of the GRCBL is that it is highly interactive in nature, and I’ve always encouraged this. |
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| John Eaton |
01/06 |
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| inclement weather. John Eaton has been with NCI for 20 years as Contracting Officer for the four large contracts that support the NCI-Frederick scientists. In this capacity he works directly with the contractors, letting them know exactly what the government wants. |
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| Dr. Charmaine Richman |
12/05 |
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| One person who has chosen an alternate path within the scientific community is Dr. Charmaine Richman. She is the Intellectual Property Administrator for SAIC-Frederick, Inc., and works closely with SAIC-Frederick employees who support the NCI labs at Ft. Detrick. |
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| Neal Copeland, Ph.D. |
10/05 |
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| Neal Copeland is a man used to looking at things a bit differently. With a Ph.D. in biochemistry, this gourmet cook and world traveler began his career doing postdoctoral work in retrovirology at the Dana Farber Cancer Center, Harvard Medical School, and also learned molecular biology along the way. |
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| Dr. John M. Coffin |
08/05 |
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| Dr. Coffin helps guide the DRP’s broad approaches; carries out general administrative, personnel, and budgetary duties; and plans special seminars, workshops, poster sessions and oral presentations. |
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| Patricia Fritz, D.V.M. |
07/05 |
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| Dr. Fritz is principal investigator for the Animal Production Area (APA) contract, which is held by Charles River Laboratories (CRL). |
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| Dr. John Ortaldo, Laboratory of Experimental Immunology: On Target with the NCI |
05/05 |
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| Having the freedom to perform cellular and molecular research in cancer ... having good support ... working in a good facility: all of these attracted Dr. John Ortaldo, chief of the Laboratory of Experimental Immunology (LEI), to the National Institutes of Health in the early 1970s. |
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| Laboratory of Cell-Mediated Immunity |
04/05 |
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| The Laboratory of Cell Mediated Immunity (LCMI), headed by Dr. Anatoli Malyguine helps integrate NIH’s clinical and basic research by testing, developing, and enhancing immunological assays that are used to evaluate a patient’s response to a particular vaccine. |
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| Take Your Child to Work Day |
03/05 |
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| This summer we will celebrate the ninth annual “Take Your Child to Work Day” (TYCTWD) at the NCI-Frederick and Fort Detrick: Wednesday, July 13, 2005.
Through this event, hundreds of children over the years have been able to see their parents, guardians, or other relatives in a unique way—at work—and at the same time the children have had a day filled with exciting and educational activities.
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| Dr. Jeffrey Lifson |
02/05 |
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| NCI-Frederick researchers are among the world’s leaders in the search to prevent and treat HIV infection. Among these scientists is Dr. Jeffrey Lifson, who heads the AIDS Vaccine Program at NCI-Frederick. |
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| Meet Lori Holliday |
01/05 |
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| The new manager of the Administrative Resource Center (ARC), NCI-Frederick, isn’t a rookie when it comes to working for laboratories in the National Cancer Institute. In fact, she was instrumental in the hiring of more than 100 people for one of the largest programs at NCI-Frederick... |
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| Dr. Jeffrey Strathern |
10/04 |
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| The research conducted in Dr. Jeffrey Strathern’s Genome Recombination and Regulation Section provides a good example of how an examination of those biological processes that are common to all living organisms serves as a foundation for further studies. Dr. Strathern and his colleagues use the yeast model system (Saccharomyces cerevisiae) to study the fidelity of genetic replication and recombination. |
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| Dr. Xinhua Ji |
09/04 |
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| Xinhua Ji began his career taking care of the basic medical needs of a small village in Northeast China. With only a high school education, and a basic knowledge of chemistry, which he had gleaned from his classes, he became responsible for the health care of 1,000 people who lived in the small town. |
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| Dr. Gordon Cragg |
08/04 |
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| From Johnny Weismuller’s Tarzan’s Desert Mystery (1943) to Sean Connery’s Medicine Man (1992), movies have depicted the jungle as a mysterious place secreting cures that will save the world’s population from disease. NCI-Frederick’s own “medicine man,” Dr. Gordon Cragg, head of the Natural Products Branch of the NCI Developmental Therapeutics Program (DTP) is full of enthusiasm but also realistic about his chosen field. |
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| Dr. Stephen Hughes |
07/04 |
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| 'In science, there is the magic of the epiphany, and that is wonderful.' So explains Dr. Stephen Hughes, chief of the Retroviral Replication Laboratory and Vector Design and Replication Section in the HIV Drug Resistance Program. |
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| Sue Wilson |
06/04 |
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| One of the joys of this 'Spotlight' column is demonstrating the ways in which NCI-Frederick people 'break the mold,' both professionally and personally. Sue Wilson certainly is one who doesn't conform to the librarian stereotype. |
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| Take Your Child to Work Day: A Step Toward Your Child's Future |
05/04 |
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| In partnership with the U.S. Army Medical Research and Materiel Command and Fort Detrick, the National Cancer Institute at Frederick (NCI-Frederick) is sponsoring the seventh annual 'Take Your Child to Work Day' (TYCTWD) on Wednesday, July 21, 2004 |
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| The NCI-Frederick Central Repository - A Transformation in Progress |
04/04 |
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| The NCI-Frederick Central Repository is undergoing a major transformation. It began about 20 months ago with SAIC-Frederick, Inc. awarding a subcontract to McKesson BioServices, Inc. (MBS) for managing the day-to-day activities of the Central Repository under the direction of Dr. Kathleen Groover and her team of repository professionals. Immediately after, the Repository Quality Board (RQB) was reorganized to oversee the direction of this dynamic and critical repository operation. |
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| Ken Michaels: Scientific Publications, Graphics and Media |
03/04 |
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| 'Our mission is to help all of our scientists communicate their science to others more effectively, so we see communications as an end-to-end process that begins with the concept and goes all the way through design and production and ultimately, delivery to the audience,' Michaels said. |
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| Dr. Mary Carrington: The Management of Science |
02/04 |
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| 'Having a full plate' aptly describes Dr. Mary Carrington's life. Dr. Carrington is an SAIC-Frederick, Inc. Principal Investigator (PI) within the Laboratory of Genomic Diversity and serves as Director of SAIC-Frederick's Basic Science Directorate. The Basic Science Directorate is divided into two programs-the Basic Research Program (BRP), which Dr. Carrington oversees and the AIDS Vaccine Program (AVP) headed by Dr. Jeffrey Lifson. |
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| Student Intern Program |
01/04 |
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| Unique to the NCI-Frederick, the Werner H. Kirsten Student Intern Program (SIP) gives high school seniors the opportunity to get hands-on research experience. Dr. Werner H. Kirsten, Associate Director of NCI-Frederick from 1988 until his sudden death in December of 1992, was a distinguished professor and researcher, and this internship program was established in his memory. |
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| Dr. Timothy Veenstra |
12/03 |
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| Mass spectrometry (MS) is fast becoming the leading tool for rapid and accurate identification of proteins that play a key role in the development of cancer. Dr. Timothy Veenstra, Director of the Mass Spectrometry Center, Biomedical Proteomics Program (BPP), has recognized the potential power of this technique in detecting early-stage cancer. |
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| Grace Yeh, PhD |
11/03 |
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| Dr. Yeh was recruited by Dr. Peter Greenwald the Director of the Division of Cancer Prevention and Dr. James Phang (Laboratory Chief) to set up a lab focusing on cancer prevention at NCI-Frederick. |
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| Larry O. Arthur, PhD |
09/03 |
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| Dr. Larry Arthur is a principal investigator (PI) in two dimensions of the term: Principal Investigator for the Operations and Technical Support (OTS) Contract, and Principal Investigator for the AIDS Vaccine Program. In addition, he serves as president of SAIC-Frederick, Inc., which holds the contract. “At SAIC-Frederick, the only thing we do is run the OTS contract; everyone is totally dedicated to it,” Dr. Arthur said in a recent interview for this column. |
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| Carol Shearer and the Building 470 Team |
08/03 |
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| Ask someone at NCI-Frederick where Building 470 is located, and you may get a puzzled look. Ask anyone where the “anthrax tower” is, however, and you will quickly be pointed in the right direction. |
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| Seventh Annual Spring Research Festival May 14-15, 2003 |
06/03 |
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| The third week of May is always eagerly anticipated at the National Cancer Institute at Frederick. That?s when NCI-Frederick and the U.S. Army Medical Research and Materiel Command jointly host the annual Spring Research Festival. |
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| Dr. Berton Zbar, Laboratory of Immunobiology |
04/03 |
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| Since 1985, Dr. Berton Zbar and his colleagues have been studying families affected
with the von Hippel-Lindau syndrome (VHL), hereditary papillary renal carcinoma
(HPRC), the Birt-Hogg-Dubé syndrome (BHD), and most recently, Hereditary Leiomyoma Renal Cell Carcinoma (HLRCC). |
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| Dr. Michael Dean, Principal Investigator,
Laboratory of Genomic Diversity |
03/03 |
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| Part of the mission of the National Cancer Institute at Frederick has long been
translational research: moving research out of the laboratory and into practical
applications. That certainly has held true for Dr. Michael Dean, Principal Investigator,
Laboratory of Genomic Diversity, NCI-Frederick. |
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| Associate Director, NCI at Frederick |
02/03 |
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| How do Drs. Robert Wiltrout and Craig Reynolds view NCI at Frederick?s current and
future roles within the NIH community? This is the second of two articles highlighting
the thoughts, issues, and goals of the Wiltrout/Reynolds management team. |
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| Dr. Craig Reynolds |
10/02 |
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| How do Drs. Craig Reynolds and Robert Wiltrout view NCI at Frederick's current and future roles within the NIH community? This is the first of two articles highlighting the thoughts, issues, and goals of the Reynolds/Wiltrout management team. |
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