Our Science – LPDS Website

Laboratory of Protein Dynamics and Signaling

Research

The Laboratory of Protein Dynamics and Signaling (LPDS) investigates mechanisms that regulate the fundamental cellular processes of differentiation, proliferation, survival, apoptosis and tumorigenesis. LPDS research is predicated on the concept that understanding normal cellular function and human disease requires a solid mechanistic comprehension of crucial signaling pathways, their points of intersection and divergence as well as differential regulation by dynamic alterations in critical regulatory proteins.

Areas of focus within the LPDS include the role of CEBP transcription factors in either promoting or inhibiting carcinogenesis and their roles in survival and differentiation; Nodal signaling through the TGFb superfamily and the role of Nodal in differentiation. The LPDS also has a strong emphasis on enzymes and substrates for both ubiquitination and sumoylation. The LPDS has strong ties to the NCI Molecular Targets Development program as well as to the structural biology Laboratories at NCI Frederick.

This page was last updated on 11/20/2007.