Our Science – MTDP Website

Molecular Targets Development Program

In addition to the information presented below, the MTDP has an alternative website that can provide you with more detail about their work.

Research

The Molecular Targets Development Program (MTDP) provides leadership for converting CCR's basic sciences advances into drug leads, bioprobes, and reagents for molecular target evaluation. The MTDP exploits chemical and biodiversity repositories, including the NCI Natural Products Repository, for molecularly targeted lead discovery.

The MTDP also facilitates the discovery of natural products and synthetic compounds that may serve as bioprobes for chemical genetics, proteomics, target validation, and potential lead compounds for clinical development. Compounds of interest include classical drug-like organic small molecules, and peptides, proteins, and other bioactive chemical classes. MTDP's services include:

- Advising CCR scientists on molecular targets and drug discovery.

- Developing screening assays for biomolecules that interact with molecular targets.

- Evaluating natural products and synthetic compound libraries.

- Implementing screens to identify biomolecules that interact with molecular targets.

- Isolating, characterizing, and validating hits from screens.

- Advising and facilitating development of potential new research reagents and preclinical development of promising lead compounds.

- Training pre- and postdoctoral scientists.

To learn more about program specifics, click on the links below:

Organization
Collaborations
Steering Committee
Accomplishments
Project Seminars
Training
MTDP Intranet
Laboratory Tour

This page was last updated on 2/4/2008.