Mission Statement:
- Plans and conducts investigation on the effect of alcohol on cell structure and function at the molecular level;
- investigates the molecular mechanisms involved in the development of alcoholism and alcohol-induced pathologies;
- trains investigators in research approaches to alcohol abuse and alcoholism;
- collaborates with organizations outside of the Institute in studies related to the effects of alcohol abuse on molecular mechanisms, and
- studies the effects of ethanol and its metabolites on the processes which control metabolism.
Staff:
Selected Publications:
Cascante M, Centelles JJ, Veech RL, Lee WN, Boros LG. Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. Nutr Cancer 2000; 36 :150-4. [ PDF ]
Jeong KS, Park SJ, Lee CS, Kim TW, Kim SH, Ryu SY, Williams BH, Veech RL, Lee YS. Effects of cyclocreatine in rat hepatocarcinogenesis model. Anticancer Res 2000; 20 :1627-33.
Kashiwaya Y, Takeshima T, Mori N, Nakashima K, Clarke K, Veech RL. D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A 2000; 97 :5440-4. [ PDF ]
Kashiwaya Y, King MT, Veech RL: Substrate signaling by insulin: a ketone bodies ratio mimics insulin action in heart. Am J Cardiol 1997; 80 :50A-64A.
Kashiwaya Y, Sato K, Tsuchiya N, Thomas S, Fell DA, Veech RL, Passonneau JV: Control of glucose utilization in working perfused rat heart. J Biol Chem 1994 Oct 14; 269:25502-14.
Sato K, Kashiwaya Y, Keon CA, Tsuchiya N, King MT, Radda GK, Chance B, Clarke K, Veech RL: Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J 1995 May; 9:651-8.
Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF Jr. Ketone bodies, potential therapeutic uses. IUBMB Life. 2001; 51 :241-7. Review. [ PDF ]
Veech RL, Fell DA: Distribution control of metabolic flux. Cell Biochem Funct. 1996; 14 :229-36.
Veech RL: Physiological approaches to increase biocompatibility of peritoneal dialysis. Perit Dial Int. 1996; 16 :332-3.
Veech RL, Kashiwaya Y, King MT: The resting membrane potential of cells are measures of electrical work, not of ionic currents. Integr Physiol Behav Sci. 1995 Sep-Dec; 30 :283-307.
Alcohol publications can also be found using ETOH Database
Updated: July 2004