Chen Q., Espey M.G., Sun A., Poupot C., Kirk K., Cherukuri M., Khosh D.B., Drisko J., Levine M. (2008) Pharmacologic doses of ascorbate act as a pro oxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci USA. 105:11105-9.
Hoffer L.J., Levine M., Assouline S., Melnychuk D., Padayatty S.J., Rosadiuk K., Rousseau C., Robitaille L., Miller W.H. Jr. (2008) Phase I clinical trial of intravenous ascorbate in advanced malignancy Annal Oncol 19: 1969-74
Padayatty S., Doppman J.L., Chang, R., Wang Y., Gill J., Papanicolau D., Levine M. (2007) Adrenal glands secrete vitamin C in response to ACTH in humans. American Journal of Clinical Nutrition 86, 145-9.
Chen Q., Espey M.G., Cherukuri M.K., Sun A., Buettner G.R., Shacter E., Poupot C., Kirk K., Levine M. (2007) Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci USA 107, 8749-54.
Kwon O., Eck P., Chen S., Corpe C., Lee J-h., Kruhlak M., Levine M. (2007) Inhibition of the intestinal glucose transporter GLUT 2 by flavonoids. FASEB Journal 21, 366-77.
Chen Q., Espey M.G., Cherukuri M.K., Mitchell J.B., Corpe C.P., Buettner G.R., Shacter E., Levine M. (2005) Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA. 102: 13604-13609.
Corpe C., Lee J-H., Kwon O., Eck P., Narayanan J., Kirk K., Levine M. (2005) 6-bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+dependent vitamin C transporter but not glucose transporter pathways. J Biol. Chem. 280:5211-5220.
Eck P., Erichsen H.C., Taylor J.G., Yeager M., Hughes A.L., Levine M. , Chanock S.J.(2004) Comparison of the genomic structure and variation in the two human sodium dependent vitamin C transporters, SLC23A1 and SLC23A2. Human Genetics, 115:285-294.
Padayatty S.J., Sun H., Wang Y., Riordan H.D., Hewitt S.M., Katz A., Wesley R.A., Levine M. (2004) Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use. Annals of Internal Medicine 140: 533-7.
Song J., Kwon O., Chen S., Daruwala R., Eck P., Park J.B., Levine M. (2002) Flavonoid inhibition of SVCT1 and GLUT2, intestinal transporters for vitamin C and glucose. J. Biol. Chem. 277, 15252-60.
Sotiriou S., Gispert S., Chen A., Cheng J., Wang Y., Hoogstraten-Miller S., Miller G.F., Kwon O., Levine M., Guttentag S.H., Nussbaum R.L. (2002) Ascorbic acid transporter slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nature Medicine 8, 514-17.
Levine M., Wang Y., Padayatty S.J., Morrow J.D. (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA. 98; 9842-46.