DPP Research Group. N Engl J Med 2002, Vol.346, No. 6.
Note:
Diabetes Prevention Program (DPP) participants were randomly assigned to one of three interventions:
The intensive lifestyle modification program, where participants were encouraged to lose 5% to 7% of their bodyweight by following a healthy low-calorie, low-fat diet and by getting 30 minutes of physical activity, 5 days a week.
Standard lifestyle recommendations plus metformin, an oral diabetes drug.
Standard lifestyle recommendations plus placebo twice daily.
Reference
Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, Vol.346, No. 6.